EXENATIDE

Description
Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/021773s041lbl.pdf | https://www.ncbi.nlm.nih.gov/pubmed/28085521

Exenatide (exendin-4) is sold under the brand name BYETTA to improve glycemic control in people with type 2 diabetes mellitus. Exenatide is a glucagon-like peptide 1 (GLP-1) receptor agonist that enhances glucose-dependent insulin secretion by the pancreatic beta cell, suppresses inappropriately elevated glucagon secretion, and slows gastric emptying. The drug also moderates peak serum glucagon levels during hyperglycemic periods following meals but does not interfere with glucagon release in response to hypoglycemia.

CNS Activity

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Glucagon-like peptide 1 receptor 5 Target ID: P43220 Gene ID: 2740.0 Gene Symbol: GLP1R Target Organism: Homo sapiens (Human) Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/021773s041lbl.pdf \| https://www.ncbi.nlm.nih.gov/pubmed/20649595	Agonist 2752

Conditions

Condition	Modality	Targets	Highest Phase	Product
Type 2 diabetes mellitus 262 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2005/021773lbl.pdf	Palliative		Approved 8583	BYETTA Approved Use BYETTA (exenatide) is a glucagon-like peptide-1 (GLP-1) receptor agonist indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. Launch Date 2005

PubMed

Title	Date	PubMed
High fat diet and GLP-1 drugs induce pancreatic injury in mice.	2014-04-15	24534256
Pulmonary GLP-1 receptor increases at birth and exogenous GLP-1 receptor agonists augmented surfactant-protein levels in litters from normal and nitrofen-treated pregnant rats.	2013-03	23354098
On-target effects of GLP-1 receptor agonists on thyroid C-cells in rats and mice.	2013-02	23471186
Oleic acid and glucose regulate glucagon-like peptide 1 receptor expression in a rat pancreatic ductal cell line.	2012-10-15	22925809
Down-regulation of zinc transporter 8 in the pancreas of db/db mice is rescued by Exendin-4 administration.	2010-09-01	21461562
Diabesity: therapeutic options.	2010-06	20518802
Biochemical, pharmaceutical and therapeutic properties of long-acting lithocholic acid derivatized exendin-4 analogs.	2010-03-03	19900495
Exendin-4 exerts osteogenic actions in insulin-resistant and type 2 diabetic states.	2010-01-08	19586609
Preparation and structural, biochemical, and pharmaceutical characterizations of bile acid-modified long-acting exendin-4 derivatives.	2009-11-12	19827752
Exenatide-associated ischemic renal failure.	2009-02	19171732
Caudal brainstem processing is sufficient for behavioral, sympathetic, and parasympathetic responses driven by peripheral and hindbrain glucagon-like-peptide-1 receptor stimulation.	2008-08	18420740
Glucagon-like peptide 1 receptor stimulation reverses key deficits in distinct rodent models of Parkinson's disease.	2008-05-21	18492290

Sample Use Guides

In Vivo Use Guide

Inject subcutaneously within 60 minutes prior to morning and evening meals (or before the two main meals of the day, approximately 6 hours or more apart)

Route of Administration: Other

Substance Class	Protein Created by `admin` on `Wed Apr 02 11:39:55 GMT 2025` Edited by `admin` on `Wed Apr 02 11:39:55 GMT 2025`
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	9P1872D4OL
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

EXENATIDE

Official Name

English

EXENATIDE SYNTHETIC

Preferred Name

English

AC-2993LAR

Code

English

EXENATIDE [USAN]

Common Name

English

AC2993

Code

English

EXENATIDE [USP-RS]

Common Name

English

ITCA-650

Code

English

exenatide [INN]

Common Name

English

HIS-GLY-GLU-GLY-THR-PHE-THR-SER-ASP-LEU-SER-LYS-GLN-MET-GLU-GLU-GLU-ALA-VAL-ARG-LEU-PHE-ILE-GLU-TRP-LEU-LYS-ASN-GLY-GLY-PRO-SER-SER-GLY-ALA-PRO-PRO-PRO-SER-NH2

Systematic Name

English

LY2148568

Code

English

EXENATIDE [JAN]

Common Name

English

AC-2993

Code

English

EXENDIN-4

Code

English

EXENATIDE [HSDB]

Common Name

English

L-SERINAMIDE, L-HISTIDYLGLYCYL-L-.ALPHA.-GLUTAMYLGLYCYL-L-THREONYL-L-PHENYLALANYL-L-THREONYL-L-SERYL-L-.ALPHA.-ASPARTYL-L-LEUCYL-L-SERYL-L-LYSYL-L-GLUTAMINYL-L-METHIONYL-L-.ALPHA.-GLUTAMYL-L-.ALPHA.-GLUTAMYL-L-.ALPHA.-GLUTAMYL-L-ALANYL-L-VALYL-L-ARGINYL-

Systematic Name

English

EXENATIDE [EMA EPAR]

Common Name

English

EXENDIN 4

Common Name

English

EXENATIDE [VANDF]

Common Name

English

BYDUREON

Brand Name

English

DA-3091

Code

English

EXENDIN-4 [MI]

Common Name

English

BYETTA

Brand Name

English

Exenatide [WHO-DD]

Common Name

English

AC2993A

Code

English

AC002993

Code

English

LY-2148568

Code

English

EXENATIDE [USP MONOGRAPH]

Common Name

English

EXENATIDE [ORANGE BOOK]

Common Name

English

EXENATIDE [MART.]

Common Name

English

EXENATIDE SYNTHETIC [ORANGE BOOK]

Common Name

English

AC-2993A

Code

English

BYDUREON BCISE

Brand Name

English

AC-002993

Code

English

Classification Tree Code System Code

NDF-RT

N0000170335