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Description

Exenatide (exendin-4) is sold under the brand name BYETTA to improve glycemic control in people with type 2 diabetes mellitus. Exenatide is a glucagon-like peptide 1 (GLP-1) receptor agonist that enhances glucose-dependent insulin secretion by the pancreatic beta cell, suppresses inappropriately elevated glucagon secretion, and slows gastric emptying. The drug also moderates peak serum glucagon levels during hyperglycemic periods following meals but does not interfere with glucagon release in response to hypoglycemia.

CNS Activity

CNS Penetrant
2554
Curator's Comment: Referenced study was conducted in mice

Approval Year

2005
131
Targets

Targets

Primary TargetPharmacologyConditionPotency
Agonist
2678
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
Approved
8429
BYETTA

Approved Use

BYETTA (exenatide) is a glucagon-like peptide-1 (GLP-1) receptor agonist indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Launch Date

2005
PubMed

PubMed

TitleDatePubMed
Caudal brainstem processing is sufficient for behavioral, sympathetic, and parasympathetic responses driven by peripheral and hindbrain glucagon-like-peptide-1 receptor stimulation.
2008 Aug
Glucagon-like peptide 1 receptor stimulation reverses key deficits in distinct rodent models of Parkinson's disease.
2008 May 21
Exendin-4 exerts osteogenic actions in insulin-resistant and type 2 diabetic states.
2010 Jan 8
Diabesity: therapeutic options.
2010 Jun
Oleic acid and glucose regulate glucagon-like peptide 1 receptor expression in a rat pancreatic ductal cell line.
2012 Oct 15
On-target effects of GLP-1 receptor agonists on thyroid C-cells in rats and mice.
2013 Feb
Pulmonary GLP-1 receptor increases at birth and exogenous GLP-1 receptor agonists augmented surfactant-protein levels in litters from normal and nitrofen-treated pregnant rats.
2013 Mar
High fat diet and GLP-1 drugs induce pancreatic injury in mice.
2014 Apr 15

Sample Use Guides

In Vivo Use Guide
Inject subcutaneously within 60 minutes prior to morning and evening meals (or before the two main meals of the day, approximately 6 hours or more apart)
Route of Administration: Other
Substance Class Protein
Created
by admin
on Sat Dec 16 18:35:38 GMT 2023
Edited
by admin
on Sat Dec 16 18:35:38 GMT 2023
Protein Sub Type
Sequence Type COMPLETE
Record UNII
9P1872D4OL
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
EXENATIDE
EMA EPAR   HSDB   INN   JAN   MART.   USAN   VANDF   WHO-DD  
INN   USAN  
Official Name English
AC-2993LAR
Code English
EXENATIDE [USAN]
Common Name English
AC2993
Code English
EXENATIDE [USP-RS]
Common Name English
ITCA-650
Code English
exenatide [INN]
Common Name English
HIS-GLY-GLU-GLY-THR-PHE-THR-SER-ASP-LEU-SER-LYS-GLN-MET-GLU-GLU-GLU-ALA-VAL-ARG-LEU-PHE-ILE-GLU-TRP-LEU-LYS-ASN-GLY-GLY-PRO-SER-SER-GLY-ALA-PRO-PRO-PRO-SER-NH2
Systematic Name English
LY2148568
Code English
EXENATIDE [JAN]
Common Name English
AC-2993
Code English
EXENDIN-4
Code English
EXENATIDE [HSDB]
Common Name English
L-SERINAMIDE, L-HISTIDYLGLYCYL-L-.ALPHA.-GLUTAMYLGLYCYL-L-THREONYL-L-PHENYLALANYL-L-THREONYL-L-SERYL-L-.ALPHA.-ASPARTYL-L-LEUCYL-L-SERYL-L-LYSYL-L-GLUTAMINYL-L-METHIONYL-L-.ALPHA.-GLUTAMYL-L-.ALPHA.-GLUTAMYL-L-.ALPHA.-GLUTAMYL-L-ALANYL-L-VALYL-L-ARGINYL-
Systematic Name English
EXENATIDE [EMA EPAR]
Common Name English
EXENDIN 4
Common Name English
EXENATIDE [VANDF]
Common Name English
BYDUREON
Brand Name English
DA-3091
Code English
EXENDIN-4 [MI]
Common Name English
BYETTA
Brand Name English
Exenatide [WHO-DD]
Common Name English
AC2993A
Code English
AC002993
Code English
LY-2148568
Code English
EXENATIDE [USP MONOGRAPH]
Common Name English
EXENATIDE [ORANGE BOOK]
Common Name English
EXENATIDE [MART.]
Common Name English
EXENATIDE SYNTHETIC [ORANGE BOOK]
Common Name English
AC-2993A
Code English
EXENATIDE SYNTHETIC
ORANGE BOOK  
Common Name English
BYDUREON BCISE
Brand Name English
AC-002993
Code English
Classification Tree Code System Code
NDF-RT N0000170335
Created by admin on Sat Dec 16 18:35:38 GMT 2023 , Edited by admin on Sat Dec 16 18:35:38 GMT 2023
WHO-ATC A10BJ01
Created by admin on Sat Dec 16 18:35:38 GMT 2023 , Edited by admin on Sat Dec 16 18:35:38 GMT 2023
EU-Orphan Drug EU/3/16/1629
Created by admin on Sat Dec 16 18:35:38 GMT 2023 , Edited by admin on Sat Dec 16 18:35:38 GMT 2023
WHO-ATC A10BX04
Created by admin on Sat Dec 16 18:35:38 GMT 2023 , Edited by admin on Sat Dec 16 18:35:38 GMT 2023
WHO-VATC QA10BX04
Created by admin on Sat Dec 16 18:35:38 GMT 2023 , Edited by admin on Sat Dec 16 18:35:38 GMT 2023
FDA ORPHAN DRUG 530516
Created by admin on Sat Dec 16 18:35:38 GMT 2023 , Edited by admin on Sat Dec 16 18:35:38 GMT 2023
NDF-RT N0000178480
Created by admin on Sat Dec 16 18:35:38 GMT 2023 , Edited by admin on Sat Dec 16 18:35:38 GMT 2023
NDF-RT N0000020058
Created by admin on Sat Dec 16 18:35:38 GMT 2023 , Edited by admin on Sat Dec 16 18:35:38 GMT 2023
LIVERTOX NBK548665
Created by admin on Sat Dec 16 18:35:38 GMT 2023 , Edited by admin on Sat Dec 16 18:35:38 GMT 2023
Code System Code Type Description
WIKIPEDIA
EXENATIDE
Created by admin on Sat Dec 16 18:35:38 GMT 2023 , Edited by admin on Sat Dec 16 18:35:38 GMT 2023
PRIMARY
RXCUI
60548
Created by admin on Sat Dec 16 18:35:38 GMT 2023 , Edited by admin on Sat Dec 16 18:35:38 GMT 2023
PRIMARY RxNorm
EPA CompTox
DTXSID9040475
Created by admin on Sat Dec 16 18:35:38 GMT 2023 , Edited by admin on Sat Dec 16 18:35:38 GMT 2023
PRIMARY
MESH
C074031
Created by admin on Sat Dec 16 18:35:38 GMT 2023 , Edited by admin on Sat Dec 16 18:35:38 GMT 2023
PRIMARY
SMS_ID
100000089569
Created by admin on Sat Dec 16 18:35:38 GMT 2023 , Edited by admin on Sat Dec 16 18:35:38 GMT 2023
PRIMARY
DRUG CENTRAL
1123
Created by admin on Sat Dec 16 18:35:38 GMT 2023 , Edited by admin on Sat Dec 16 18:35:38 GMT 2023
PRIMARY
CAS
141758-74-9
Created by admin on Sat Dec 16 18:35:38 GMT 2023 , Edited by admin on Sat Dec 16 18:35:38 GMT 2023
PRIMARY
NCI_THESAURUS
C65611
Created by admin on Sat Dec 16 18:35:38 GMT 2023 , Edited by admin on Sat Dec 16 18:35:38 GMT 2023
PRIMARY
LACTMED
Exenatide
Created by admin on Sat Dec 16 18:35:38 GMT 2023 , Edited by admin on Sat Dec 16 18:35:38 GMT 2023
PRIMARY
INN
8219
Created by admin on Sat Dec 16 18:35:38 GMT 2023 , Edited by admin on Sat Dec 16 18:35:38 GMT 2023
PRIMARY
IUPHAR
1135
Created by admin on Sat Dec 16 18:35:38 GMT 2023 , Edited by admin on Sat Dec 16 18:35:38 GMT 2023
PRIMARY
CHEBI
64073
Created by admin on Sat Dec 16 18:35:38 GMT 2023 , Edited by admin on Sat Dec 16 18:35:38 GMT 2023
PRIMARY
ChEMBL
CHEMBL414357
Created by admin on Sat Dec 16 18:35:38 GMT 2023 , Edited by admin on Sat Dec 16 18:35:38 GMT 2023
PRIMARY
FDA UNII
9P1872D4OL
Created by admin on Sat Dec 16 18:35:38 GMT 2023 , Edited by admin on Sat Dec 16 18:35:38 GMT 2023
PRIMARY
EVMPD
SUB21818
Created by admin on Sat Dec 16 18:35:38 GMT 2023 , Edited by admin on Sat Dec 16 18:35:38 GMT 2023
PRIMARY
CAS
141732-76-5
Created by admin on Sat Dec 16 18:35:38 GMT 2023 , Edited by admin on Sat Dec 16 18:35:38 GMT 2023
SUPERSEDED
MERCK INDEX
m5225
Created by admin on Sat Dec 16 18:35:38 GMT 2023 , Edited by admin on Sat Dec 16 18:35:38 GMT 2023
PRIMARY
HSDB
7789
Created by admin on Sat Dec 16 18:35:38 GMT 2023 , Edited by admin on Sat Dec 16 18:35:38 GMT 2023
PRIMARY
USAN
NN-05
Created by admin on Sat Dec 16 18:35:38 GMT 2023 , Edited by admin on Sat Dec 16 18:35:38 GMT 2023
PRIMARY
DRUG BANK
DB01276
Created by admin on Sat Dec 16 18:35:38 GMT 2023 , Edited by admin on Sat Dec 16 18:35:38 GMT 2023
PRIMARY
DAILYMED
9P1872D4OL
Created by admin on Sat Dec 16 18:35:38 GMT 2023 , Edited by admin on Sat Dec 16 18:35:38 GMT 2023
PRIMARY
RS_ITEM_NUM
1269105
Created by admin on Sat Dec 16 18:35:38 GMT 2023 , Edited by admin on Sat Dec 16 18:35:38 GMT 2023
PRIMARY
Related Record Type Details
Visepegenatide
CONJUGATE -> PARENT
GLUCAGON-LIKE PEPTIDE 1 RECEPTOR
TARGET -> AGONIST
Related Record Type Details
EXENATIDE
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT:SEQUENCE(CALCULATED) CHEMICAL
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
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