GLUCAGON-LIKE PEPTIDE 1 RECEPTOR

Investigational

Approval Year

Substance Class	Protein Created by `admin` on `Sat Dec 16 12:10:00 UTC 2023` Edited by `admin` on `Sat Dec 16 12:10:00 UTC 2023`
Protein Type	RECEPTOR
Protein Sub Type
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	EF38T7N5MI
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

GLUCAGON-LIKE PEPTIDE 1 RECEPTOR

Common Name

English

GLP-1 RECEPTOR

Common Name

English

GLP-1R

Common Name

English

Code System Code Type Description

FDA UNII

EF38T7N5MI

Created by admin on Sat Dec 16 12:10:00 UTC 2023 , Edited by admin on Sat Dec 16 12:10:00 UTC 2023

PRIMARY

UNIPROT

P01275

Created by admin on Sat Dec 16 12:10:00 UTC 2023 , Edited by admin on Sat Dec 16 12:10:00 UTC 2023

PRIMARY

PHAROS

P01275

Created by admin on Sat Dec 16 12:10:00 UTC 2023 , Edited by admin on Sat Dec 16 12:10:00 UTC 2023

PRIMARY

From	To
1_23	1_48
1_39	1_81
1_62	1_103
1_203	1_273

Glycosylation Type

HUMAN

Glycosylation Link Type	Site
N	1_40
N	1_59
N	1_92

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Amount:


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BEINAGLUTIDE

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Amount:


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Amount:


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AGONIST -> TARGET


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Amount:


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AGONIST -> TARGET

Amount:


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DULAGLUTIDE

AGONIST -> TARGET


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MAZDUTIDE

AGONIST -> TARGET

Amount:


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DAPIGLUTIDE

AGONIST -> TARGET

Amount:


					5E7U48495E

ALBIGLUTIDE

AGONIST -> TARGET


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Tirzepatide

PARTIAL AGONIST->TARGET

Comments:

On GLP-1R, TZP is a partial agonist 51% stimulation. shows bias towards cAMP (a messenger associated with regulation of glycogen, sugar and lipid metabolism) generation, rather than β-arrestin recruitment.

Qualification:

EC50

Amount: