U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Unknown
149124
Substance Class Protein
Created
by admin
on Tue Apr 01 18:30:50 GMT 2025
Edited
by admin
on Tue Apr 01 18:30:50 GMT 2025
Protein Type RECEPTOR
Protein Sub Type
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
EF38T7N5MI
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
GLP-1 RECEPTOR
Preferred Name English
GLUCAGON-LIKE PEPTIDE 1 RECEPTOR
Common Name English
GLP-1R
Common Name English
Code System Code Type Description
FDA UNII
EF38T7N5MI
Created by admin on Tue Apr 01 18:30:50 GMT 2025 , Edited by admin on Tue Apr 01 18:30:50 GMT 2025
PRIMARY
UNIPROT
P01275
Created by admin on Tue Apr 01 18:30:50 GMT 2025 , Edited by admin on Tue Apr 01 18:30:50 GMT 2025
PRIMARY
PHAROS
P01275
Created by admin on Tue Apr 01 18:30:50 GMT 2025 , Edited by admin on Tue Apr 01 18:30:50 GMT 2025
PRIMARY
From To
1_23 1_48
1_39 1_81
1_62 1_103
1_203 1_273
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_40
N 1_59
N 1_92
Related Record Type Details
ECNOGLUTIDE
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GLUCAGON-LIKE PEPTIDE 1 RECEPTOR
AGONIST -> TARGET
BEINAGLUTIDE
AGONIST -> TARGET
Structure of COTADUTIDE
AGONIST -> TARGET
Structure of AVEXITIDE
INHIBITOR -> TARGET
Visepegenatide
AGONIST -> TARGET
Structure of Orforglipron
AGONIST -> TARGET
EXENATIDE
AGONIST -> TARGET
Olatorepatide
AGONIST -> TARGET
Gulgafafusp Alfa
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Structure of Aleniglipron
AGONIST -> TARGET
PRECLINICAL
EFOCIPEGTRUTIDE
AGONIST -> TARGET
BPI-3016
AGONIST -> TARGET
Froniglutide
AGONIST -> TARGET
Structure of BMS-686117
AGONIST -> TARGET
Pemvidutide
AGONIST -> TARGET
Bofanglutide
AGONIST -> TARGET
DULAGLUTIDE
AGONIST -> TARGET
MEDI-7219
AGONIST -> TARGET
CHO-hGLP-1R cAMP 4.4% HSA.
EC50
MAZDUTIDE
AGONIST -> TARGET
DAPIGLUTIDE
AGONIST -> TARGET
ALBIGLUTIDE
AGONIST -> TARGET
Tirzepatide
PARTIAL AGONIST->TARGET
On GLP-1R, TZP is a partial agonist 51% stimulation. shows bias towards cAMP (a messenger associated with regulation of glycogen, sugar and lipid metabolism) generation, rather than ?-arrestin recruitment.
EC50
PF-04603629
AGONIST -> TARGET
OXYNTOMODULIN HUMAN
AGONIST -> TARGET
EFINOPEGDUTIDE
AGONIST -> TARGET
G-3215
AGONIST -> TARGET
EC50
Structure of DANUGLIPRON
AGONIST -> TARGET
Efmedaglutide Alfa
AGONIST -> TARGET
Zovaglutide
AGONIST -> TARGET
LIXISENATIDE
AGONIST -> TARGET
Structure of 2-[[4-[(2S)-2-(4-Chloro-2-fluorophenyl)-2-methyl-1,3-benzodioxol-4-yl]-1-piperidinyl]methyl]-1-[(2S)-2-oxetanylmethyl]-1H-benzimidazole-6-carboxylic acid
AGONIST -> TARGET
PEGLOXENATIDE
AGONIST -> TARGET
Imapextide
INHIBITOR -> TARGET
PRECLINICAL
LIRAGLUTIDE
AGONIST -> TARGET
Retatrutide
AGONIST -> TARGET
GSK-2374697
AGONIST -> TARGET
EFPEGLENATIDE
AGONIST -> TARGET

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO ACID SUBSTITUTION [1_318] ADP-RIBOSYLCYSTEINE TES2NDN50T
AMINO ACID SUBSTITUTION [1_325] ADP-RIBOSYLARGININE D5024CP23U
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT CHEMICAL
NIH
NCATS
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