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This repository is under review for potential modification in compliance with Administration directives.

Approval Year

Unknown
149124
Substance Class Protein
Created
by admin
on Wed Apr 02 06:15:41 GMT 2025
Edited
by admin
on Wed Apr 02 06:15:41 GMT 2025
Protein Type MONOCLONAL ANTIBODY
Protein Sub Type IGG4|KAPPA
Sequence Origin HUMANIZED RAT
Sequence Type COMPLETE
Record UNII
9M1GV6L389
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
UCB-0107
Preferred Name English
BEPRANEMAB
INN   USAN  
Official Name English
bepranemab [INN]
Common Name English
RECOMBINANT HUMANISED IgG4P KAPPA LIGHT CHAIN GAMMA HEAVY CHAIN ANTI-TAU MONOCLONAL ANTIBODY UCB0107
Common Name English
IMMUNOGLOBULIN G4-KAPPA, ANTI-(HOMO SAPIENS MAPT (MICROTUBULE ASSOCIATED PROTEIN TAU, TAU)), HUMANIZED MONOCLONAL ANTIBODY; GAMMA4 HEAVY CHAIN HUMANIZED (1-445) (VH (HOMO SAPIENS IGHV4-4*08 (83.5%)-(IGHD)- IGHJ3*01 (93.3%)) CDR-IMGT (8.7.12) (26-33.51-57
Common Name English
BEPRANEMAB [USAN]
Common Name English
IMMUNOGLOBULIN G4 (226-PROLINE), ANTI-(HUMAN TAU PROTEIN) (HUMAN-RATTUS NORVEGICUS MONOCLONAL UCB0107 .GAMMA.4-CHAIN), DISULFIDE WITH HUMAN-RATTUS NORVEGICUS MONOCLONAL UCB0107 .KAPPA.-CHAIN, DIMER
Common Name English
UCB0107
Code English
Classification Tree Code System Code
FDA ORPHAN DRUG 598117
Created by admin on Wed Apr 02 06:15:41 GMT 2025 , Edited by admin on Wed Apr 02 06:15:41 GMT 2025
Code System Code Type Description
FDA UNII
9M1GV6L389
Created by admin on Wed Apr 02 06:15:41 GMT 2025 , Edited by admin on Wed Apr 02 06:15:41 GMT 2025
PRIMARY
CLINICAL_TRIALS.GOV
NCT03464227
Created by admin on Wed Apr 02 06:15:41 GMT 2025 , Edited by admin on Wed Apr 02 06:15:41 GMT 2025
PRIMARY
SMS_ID
300000001080
Created by admin on Wed Apr 02 06:15:41 GMT 2025 , Edited by admin on Wed Apr 02 06:15:41 GMT 2025
PRIMARY
NCI_THESAURUS
C174583
Created by admin on Wed Apr 02 06:15:41 GMT 2025 , Edited by admin on Wed Apr 02 06:15:41 GMT 2025
PRIMARY
USAN
JK-171
Created by admin on Wed Apr 02 06:15:41 GMT 2025 , Edited by admin on Wed Apr 02 06:15:41 GMT 2025
PRIMARY
CAS
2244960-75-4
Created by admin on Wed Apr 02 06:15:41 GMT 2025 , Edited by admin on Wed Apr 02 06:15:41 GMT 2025
PRIMARY
CLINICAL_TRIALS.GOV
NCT04185415
Created by admin on Wed Apr 02 06:15:41 GMT 2025 , Edited by admin on Wed Apr 02 06:15:41 GMT 2025
PRIMARY
INN
11224
Created by admin on Wed Apr 02 06:15:41 GMT 2025 , Edited by admin on Wed Apr 02 06:15:41 GMT 2025
PRIMARY
From To
1_22 1_95
2_22 2_95
2_132 4_219
2_145 2_201
2_259 2_319
1_132 3_219
2_365 2_423
3_23 3_93
3_139 3_199
4_23 4_93
4_139 4_199
1_145 1_201
1_224 2_224
1_227 2_227
1_259 1_319
1_365 1_423
Glycosylation Link Type Site
N 1_295
N 2_295
Related Record Type Details
MICROTUBULE-ASSOCIATED PROTEIN TAU (PAIRED HELICAL FILAMENTS (PHF))
TARGET -> INHIBITOR
Related Record Type Details
BEPRANEMAB
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL
Molecular Formula CHEMICAL
NIH
NCATS
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