Anbalcabtagene Autoleucel

Approval Year

Substance Class	Structurally Diverse Created by `admin` on `Sat Dec 16 19:17:40 UTC 2023` Edited by `admin` on `Sat Dec 16 19:17:40 UTC 2023`
Source Materials Class	ORGANISM
Source Materials Type	AUTOLOGOUS HUMAN
Source Materials State	LIVE GENETICALLY MODIFIED
Source Materials Parent	`G0T704E6Z3` HOMO SAPIENS WHOLE
Part	BLOOD
Fraction Material Type	CELL
Fraction Name	CD4/CD8 enriched T lymphocytes
Record UNII	9JHE6G6VCM
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Anbalcabtagene Autoleucel

Official Name

English

anbalcabtagene autoleucel [INN]

Common Name

English

Autologous T lymphocytes obtained from peripheral blood mononuclear cells by leukapheresis, transduced with a self-inactivating, non-replicating lentiviral vector, encoding a chimeric antigen receptor (CAR) targeting CD19, plus two short hairpin RNAs (sh

Common Name

English

Code System Code Type Description

INN

12186

Created by admin on Sat Dec 16 19:17:40 UTC 2023 , Edited by admin on Sat Dec 16 19:17:40 UTC 2023

PRIMARY

NCI_THESAURUS

C180584

Created by admin on Sat Dec 16 19:17:40 UTC 2023 , Edited by admin on Sat Dec 16 19:17:40 UTC 2023

PRIMARY

FDA UNII

9JHE6G6VCM

Created by admin on Sat Dec 16 19:17:40 UTC 2023 , Edited by admin on Sat Dec 16 19:17:40 UTC 2023

PRIMARY

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T-CELL IMMUNORECEPTOR WITH IG AND ITIM DOMAINS

TARGET -> INHIBITOR

Comments:

knockdown of TIGIT (≥83.5%)

Amount:


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PROGRAMMED CELL DEATH PROTEIN 1

TARGET -> INHIBITOR

Comments:

knockdown of PD-1 (≥33.7%)

Amount:


					IYZ9TI08W3

B-LYMPHOCYTE ANTIGEN CD19

TARGET->CYTOTOXIC T-CELL

Amount:

Related Record Type Details


					9JHE6G6VCM

Anbalcabtagene Autoleucel

ACTIVE MOIETY

Amount:

Agent Modifications

Modification Process	Modification Role	Modification Type	Fragment Name	Fragment ID
LENTIVIRAL TRANSFECTION	TRANSFECTION	GENE MODIFICATION	Anbalcabtagene autoleucel lentiviral vector	EQ6LV5J8XJ
CULTURED	EXPANSION		HUMAN INTERLEUKIN-2	FNO32LO217
CULTURE	ACTIVATOR		UNSPECIFIED SUBSTANCE	4e4ac683

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
INSERTED GENE EXPRESSION VECTOR					Anbalcabtagene autoleucel transgene insert	M5ZET26DEW
VECTOR EXPRESSED PROTEIN					Anbalcabtagene autoleucel CAR-T receptor	A83Q322Z2J

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
ENHANCED ACTIVATION	BIOLOGICAL		`P050J5FWC5` INTERFERON GAMMA