FLAVOXATE HYDROCHLORIDE

First approved in 1970

Details

Stereochemistry	ACHIRAL
Molecular Formula	C24H25NO4.ClH
Molecular Weight	427.921
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CC1=C(OC2=C(C=CC=C2C(=O)OCCN3CCCCC3)C1=O)C4=CC=CC=C4

InChI

InChIKey=XOEVKNFZUQEERE-UHFFFAOYSA-N

InChI=1S/C24H25NO4.ClH/c1-17-21(26)19-11-8-12-20(23(19)29-22(17)18-9-4-2-5-10-18)24(27)28-16-15-25-13-6-3-7-14-25;/h2,4-5,8-12H,3,6-7,13-16H2,1H3;1H

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C24H25NO4
Molecular Weight	391.4596
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a9c44c4b-5b3c-45bf-9bc9-ce858e3d06c5 | https://livertox.nlm.nih.gov/Flavoxate.htm

Flavoxate is a drug, indicated for symptomatic relief of dysuria, urgency, nocturia, suprapubic pain, frequency and incontinence as may occur in cystitis, prostatitis, urethritis, urethrocystitis/urethrotrigonitis. Flavoxate is not indicated for definitive treatment, but is compatible with drugs used for the treatment of urinary tract infections. It was approved for use in the United States in 1970 and continues to be used. Drug acts as a direct antagonist at muscarinic acetylcholine receptors in cholinergically innervated organs. Its anticholinergic-parasympatholytic action reduces the tonus of smooth muscle in the bladder, effectively reducing the number of required voids, facilitating increased volume per void. Common side effects are those of parasympathetic stimulation and include dryness of the mouth and eyes, decreased sweating, headache, visual blurring, constipation, urinary retention, impotence, tachycardia and palpitations, anxiety, restlessness and in some instances agitation and delusions.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Muscarinic acetylcholine receptors; M1 & M2 2 Target ID: CHEMBL2095219 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10858873	Antagonist 2778

Conditions

Condition	Modality	Highest Phase	Product
Cystitis 27 Sources: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a9c44c4b-5b3c-45bf-9bc9-ce858e3d06c5	Palliative	Approved 8429	FLAVOXATE HYDROCHLORIDE Approved Use Flavoxate HCl tablets are indicated for symptomatic relief of dysuria, urgency, nocturia, suprapubic pain, frequency and incontinence as may occur in cystitis, prostatitis, urethritis, urethrocystitis/urethrotrigonitis. Flavoxate HCl tablets are not indicated for definitive treatment, but are compatible with drugs used for the treatment of urinary tract infections. Launch Date 2004
Prostatitis 25 Sources: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a9c44c4b-5b3c-45bf-9bc9-ce858e3d06c5	Palliative	Approved 8429	FLAVOXATE HYDROCHLORIDE Approved Use Flavoxate HCl tablets are indicated for symptomatic relief of dysuria, urgency, nocturia, suprapubic pain, frequency and incontinence as may occur in cystitis, prostatitis, urethritis, urethrocystitis/urethrotrigonitis. Flavoxate HCl tablets are not indicated for definitive treatment, but are compatible with drugs used for the treatment of urinary tract infections. Launch Date 2004
Urethritis 18 Sources: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a9c44c4b-5b3c-45bf-9bc9-ce858e3d06c5	Palliative	Approved 8429	FLAVOXATE HYDROCHLORIDE Approved Use Flavoxate HCl tablets are indicated for symptomatic relief of dysuria, urgency, nocturia, suprapubic pain, frequency and incontinence as may occur in cystitis, prostatitis, urethritis, urethrocystitis/urethrotrigonitis. Flavoxate HCl tablets are not indicated for definitive treatment, but are compatible with drugs used for the treatment of urinary tract infections. Launch Date 2004

C_max

Value	Dose	Co-administered	Analyte	Population
4.61 mg/L EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/1026965	1.18 mg/kg single, intravenous dose: 1.18 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered:		3-METHYLFLAVONE-8-CARBOXYLIC ACID plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED
14.4 μg/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/11232858/	200 mg single, oral dose: 200 mg route of administration: Oral experiment type: SINGLE co-administered:		3-METHYLFLAVONE-8-CARBOXYLIC ACID plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED

AUC

Value	Dose	Analyte	Population
4.02 mg × h/L/(mg dose/kg) EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/1026965	2.55 mg/kg single, oral dose: 2.55 mg/kg route of administration: Oral experiment type: SINGLE co-administered:	3-METHYLFLAVONE-8-CARBOXYLIC ACID plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED
4.49 mg × h/L/(mg dose/kg) EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/1026965	1.18 mg/kg single, intravenous dose: 1.18 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered:	3-METHYLFLAVONE-8-CARBOXYLIC ACID plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED
27.85 μg × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/11232858/	200 mg single, oral dose: 200 mg route of administration: Oral experiment type: SINGLE co-administered:	3-METHYLFLAVONE-8-CARBOXYLIC ACID plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED

T_1/2

Value	Dose	Co-administered	Analyte	Population
40.1 min EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/1026965	1.18 mg/kg single, intravenous dose: 1.18 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered:		3-METHYLFLAVONE-8-CARBOXYLIC ACID plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED
4.06 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/11232858/	200 mg single, oral dose: 200 mg route of administration: Oral experiment type: SINGLE co-administered:		3-METHYLFLAVONE-8-CARBOXYLIC ACID plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED

Doses

Dose	Population	Adverse events
200 mg 3 times / day multiple, oral Dose: 200 mg, 3 times / day Route: oral Route: multiple Dose: 200 mg, 3 times / day Sources: http://www.jiaci.org/issues/vol22issue5/8-20.pdf https://pubmed.ncbi.nlm.nih.gov/10385348	unhealthy, 26 years n = 1 Health Status: unhealthy Condition: urinary infection Age Group: 26 years Sex: F Population Size: 1 Sources: http://www.jiaci.org/issues/vol22issue5/8-20.pdf https://pubmed.ncbi.nlm.nih.gov/10385348	Disc. AE: Erythema, Edema hands... AEs leading to discontinuation/dose reduction: Erythema Edema hands Sources: http://www.jiaci.org/issues/vol22issue5/8-20.pdf https://pubmed.ncbi.nlm.nih.gov/10385348
1200 mg 1 times / day multiple, oral Dose: 1200 mg, 1 times / day Route: oral Route: multiple Dose: 1200 mg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/3044876	unhealthy, 49.8 ± 9.7 years Health Status: unhealthy Condition: unstable bladder Age Group: 49.8 ± 9.7 years Sex: F Sources: https://pubmed.ncbi.nlm.nih.gov/3044876	Sources: https://pubmed.ncbi.nlm.nih.gov/3044876

AEs

AE	Significance	Dose	Population
Edema hands	Disc. AE	200 mg 3 times / day multiple, oral Dose: 200 mg, 3 times / day Route: oral Route: multiple Dose: 200 mg, 3 times / day Sources: http://www.jiaci.org/issues/vol22issue5/8-20.pdf https://pubmed.ncbi.nlm.nih.gov/10385348	unhealthy, 26 years n = 1 Health Status: unhealthy Condition: urinary infection Age Group: 26 years Sex: F Population Size: 1 Sources: http://www.jiaci.org/issues/vol22issue5/8-20.pdf https://pubmed.ncbi.nlm.nih.gov/10385348
Erythema	Disc. AE	200 mg 3 times / day multiple, oral Dose: 200 mg, 3 times / day Route: oral Route: multiple Dose: 200 mg, 3 times / day Sources: http://www.jiaci.org/issues/vol22issue5/8-20.pdf https://pubmed.ncbi.nlm.nih.gov/10385348	unhealthy, 26 years n = 1 Health Status: unhealthy Condition: urinary infection Age Group: 26 years Sex: F Population Size: 1 Sources: http://www.jiaci.org/issues/vol22issue5/8-20.pdf https://pubmed.ncbi.nlm.nih.gov/10385348

Overview

CYP3A4	CYP2C9	CYP2D6	hERG

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
P-gp 1461 MRP1 106 BCRP 699	CYP 270

Drug as perpetrator

Target	Modality	Activity
MRP1 172	inhibitor 3277 Sources: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2711991/	weak
P-gp 1650	inhibitor 3277 Sources: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2711991/	weak
BCRP 773	inhibitor 3277 Sources: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2711991/	yes [IC50 20 uM]

Drug as victim

Target	Modality	Activity	Metabolite	Clinical evidence
CYP 270	substrate 3367 Sources: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1906583/#B5	no

Sourcing

Vendor/Aggregator	ID	URL
ChEBI	CHEBI:5088	https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:5088
ChemicalBook	CB2341499	https://www.chemicalbook.com/ChemicalProductProperty_EN_CB2341499
ZINC	ZINC000000608382	http://zinc15.docking.org/substances/ZINC000000608382
eMolecules	736698	https://www.emolecules.com/cgi-bin/more?vid=736698

PubMed

Title	Date	PubMed
Association between oxybutynin and neuropsychiatric adverse effects not confirmed in daily practice.	2001 Feb	11207885
Drug therapy of urinary urge incontinence: a systematic review.	2002 Nov	12423868
The handling of urinary incontinence in Danish general practices after distribution of guidelines and voiding diary reimbursement: an observational study.	2004 Jun 29	15225353
The role of combination medical therapy in benign prostatic hyperplasia.	2008 Dec	19002123

Patents

Sample Use Guides

In Vivo Use Guide

Adults and children over 12 years of age: one or two 100 mg tablets 3 or 4 times a day. With improvement of symptoms, the dose may be reduced. This drug cannot be recommended for infants and children under 12 years of age because safety and efficacy have not been demonstrated in this age group.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:04:03 GMT 2023` Edited by `admin` on `Fri Dec 15 15:04:03 GMT 2023`
Record UNII	9C05J6089W
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FLAVOXATE HYDROCHLORIDE

Official Name

English

FLAVOXATE HYDROCHLORIDE [USP MONOGRAPH]

Common Name

English

4H-1-BENZOPYRAN-8-CARBOXYLIC ACID, 3-METHYL-4-OXO-2-PHENYL-, 2-(1-PIPERIDINYL)ETHYL ESTER, HYDROCHLORIDE

Common Name

English

FLAVOXATE HYDROCHLORIDE [USAN]

Common Name

English

FLAVOXATE HYDROCHLORIDE [MART.]

Common Name

English

FLAVOXATE HYDROCHLORIDE [ORANGE BOOK]

Common Name

English

DW-61

Code

English

FLAVOXATE HYDROCHLORIDE [EP IMPURITY]

Common Name

English

2-Piperidinoethyl 3-methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxylate hydrochloride

Systematic Name

English

FLAVOXATE HCL

Common Name

English

Flavoxate hydrochloride [WHO-DD]

Common Name

English

FLAVOXATE HYDROCHLORIDE [JAN]

Common Name

English

FLAVOXATE HYDROCHLORIDE [MI]

Common Name

English

FLAVOXATE HYDROCHLORIDE [EP MONOGRAPH]

Common Name

English

FLAVOXATE HYDROCHLORIDE [USP-RS]

Common Name

English

NSC-114649

Code

English

URISPAS

Brand Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29704