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Details

Stereochemistry ACHIRAL
Molecular Formula C26H29F2N7
Molecular Weight 477.5522
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ALMITRINE

SMILES

FC1=CC=C(C=C1)C(N2CCN(CC2)C3=NC(NCC=C)=NC(NCC=C)=N3)C4=CC=C(F)C=C4

InChI

InChIKey=OBDOVFRMEYHSQB-UHFFFAOYSA-N
InChI=1S/C26H29F2N7/c1-3-13-29-24-31-25(30-14-4-2)33-26(32-24)35-17-15-34(16-18-35)23(19-5-9-21(27)10-6-19)20-7-11-22(28)12-8-20/h3-12,23H,1-2,13-18H2,(H2,29,30,31,32,33)

HIDE SMILES / InChI
Molecular Formula C26H29F2N7
Molecular Weight 477.5522
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Almitrine, a selective pulmonary vasoconstrictor and a respiratory stimulant that enhances respiration by acting as an agonist of peripheral chemoreceptors located on the carotid bodies. The drug increases arterial oxygen tension while decreasing arterial carbon dioxide tension in patients with chronic obstructive pulmonary disease. In combination with raubasine, it used under the brand, name Duxil for the treatment of age-related cerebral disorders and functional rehabilitation after stroke. In addition, Duxil has been considered as an alternative treatment for dementia, but because of the low methodological quality of included trials and the small number of trials, the obtained data did not provide sufficient evidence to support the routine use of this drug for the disease.

Approval Year

Unknown
149124
Targets

Targets

Primary TargetPharmacologyConditionPotency
Sodium/potassium-transporting ATPase subunit alpha-1
16
Target ID: P05023|||Q9UJ20
Gene ID: 476.0
Gene Symbol: ATP1A1
Target Organism: Homo sapiens (Human)
Binding Agent
1076
PubMed

PubMed

TitleDatePubMed
Evaluation of Almitrine Infusion During Veno-Venous Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome in Adults.
2019-08
Almitrine-Raubasine combination for dementia.
2011-03-16
The neuronal guidance protein netrin-1 reduces alveolar inflammation in a porcine model of acute lung injury.
2010
Rescue strategies for refractory hypoxemia: a critical appraisal.
2009-11-26
Stability-indicating methods for the determination of a mixture of almitrine and raubasine by derivative spectrophotometry.
2009-06
Obesity hypoventilation syndrome.
2009-04
Anaesthesia for serial whole-lung lavage in a patient with severe pulmonary alveolar proteinosis: a case report.
2008-11-27
[Effect of long-time retention of scalp needle on the abilities of cognition, daily living activity and P300 in vascular dementia patients].
2008-10
Role of nitric oxide in management of acute respiratory distress syndrome.
2008-07
[Clinical investigation on electroacupuncture treatment of vascular dementia with "Xiusanzhen"].
2008-04
Current concepts in the management of hepatopulmonary syndrome.
2008
Association between inflammatory mediators and response to inhaled nitric oxide in a model of endotoxin-induced lung injury.
2008
[Combination of thiotropium bromide with almitrine and pulmonary rehabilitation in the treatment of patients with chronic obstructive pulmonary disease].
2008
Low-tidal-volume ventilation.
2007-12-13
[Observation on therapeutic effect of puncturing with needles in alignment at the hairline region on vascular dementia].
2007-06
[Clinical research of effect of Yishen Yangnao capsule on vascular dementia].
2007-04
[A clinical study on a randomized, double-blind control of Chinese medicine granules in treatment of vascular dementia].
2006-10
[The effects of antidepressant treatment on efficacy of antihypertensive therapy in elderly hypertension].
2006-08
[Effect of prepared Polygonum multiflorum on striatum extracellular acetylcholine and choline in rats of intracerebral perfusion with sodium azide].
2006-05
[Research of kingsbrain on improving the learning and memory ability of MCAO rats].
2006-03
An anesthesiologist's guide to hypoxic pulmonary vasoconstriction: implications for managing single-lung anesthesia and atelectasis.
2006-02
Low- vs high-dose almitrine combined with nitric oxide to prevent hypoxia during open-chest one-lung ventilation.
2005-09
Medroxyprogesterone improves nocturnal breathing in postmenopausal women with chronic obstructive pulmonary disease.
2005-04-04
[Effects of Tianzhi Keli on extracellular acetylcholine and catecholamine levels in striatum of rats with neuromitochondrial impairment].
2005-01
Clinical review: Independent lung ventilation in critical care.
2005
Assessment of the therapeutic activity of a combination of almitrine and raubasine on functional rehabilitation following ischaemic stroke.
2004-03
Treatment of hypoxemia during one-lung ventilation using intravenous almitrine.
2004-03
pO2 - Do we treat the right thing?
2003-12-11
Orthodeoxia--an uncommon presentation following bilateral thoracic sympathectomy.
2003-10
Long-term effects of almitrine bismesylate in COPD patients with chronic hypoxaemia.
2003-06
Selective pulmonary vasodilation in acute respiratory distress syndrome.
2003-04
[Gas exchange in acute respiratory distress syndrome].
2003
Jian Nao Ning for treatment of memory impairment in patients with mild or moderate multi-infarct dementia.
2002-12
Primary alveolar hypoventilation and response to the respiratory stimulant almitrine.
2002-12
Effect of position, nitric oxide, and almitrine on lung perfusion in a porcine model of acute lung injury.
2002-12
Vascular pharmacology of acute lung injury and acute respiratory distress syndrome.
2002-11
Effects of almitrine bismesylate on arterial blood gases in patients with chronic obstructive pulmonary disease and moderate hypoxaemia: a multicentre, randomised, double-blind, placebo-controlled study.
2002-05-22
Effect of ventilatory drive on carbon dioxide sensitivity below eupnea during sleep.
2002-05-01
Treatment of hypoxaemia during one-lung ventilation with almitrine.
2002-04-13
The effects of intravenous almitrine on oxygenation and hemodynamics during one-lung ventilation.
2002-04
[Effect of almitrine/raubasine on cerebral metabolism in the elderly].
2002-03-30
An investigation into the mechanism of action of almitrine on isolated rat diaphragm muscle fatigue.
2002
Effects of almitrine on diaphragm contractile properties in young and old rats.
2002
High or low doses of almitrine bismesylate in ARDS patients responding to inhaled NO and receiving norepinephrine?
2001-11
Oxygen sensitive chemoreceptors in the first gill arch of the tadpole, Rana catesbeiana.
2001-11
[Comparative changes in PaO2 in moderately hypoxemic COPD patients treated with almitrine versus placebo for one year].
2001-09
The oxygenation variations related to prone positioning during mechanical ventilation: a clinical comparison between ARDS and non-ARDS hypoxemic patients.
2001-08
Biliary drug lithiasis: dipyridamole gallstones.
1992-11-28
Peripheral neuropathy in patients treated with almitrine dimesylate.
1985-06-01
[Competitive study of the effects of naloxone and of almitrine on fentanyl analgesia in the anesthetized dog: effects on the muzzle opening reflex and blood gases].
1980
Substance Class Chemical
Created
by admin
on Mon Mar 31 17:56:19 GMT 2025
Edited
by admin
on Mon Mar 31 17:56:19 GMT 2025
Record UNII
9A1222NBG4
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ALMITRINE [MI]
Preferred Name English
ALMITRINE
INN   MI   WHO-DD  
INN  
Official Name English
1,3,5-TRIAZINE-2,4-DIAMINE, 6-(4-(BIS(4-FLUOROPHENYL)METHYL)-1-PIPERAZINYL)-N,N'-DI-2-PROPENYL-
Systematic Name English
Almitrine [WHO-DD]
Common Name English
2,4-BIS(ALLYLAMINO)-6-(4-(BIS(P-FLUOROPHENYL)METHYL)-1-PIPERAZINYL)-S-TRIAZINE
Common Name English
almitrine [INN]
Common Name English
6-(4-(BIS(4-FLUOROPHENYL)METHYL)1-PIPERAZINYL)-N,N'-DI-2-PROPENYL-1,3,5-TRIAZINE-2,4-DIAMINE
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C47795
Created by admin on Mon Mar 31 17:56:19 GMT 2025 , Edited by admin on Mon Mar 31 17:56:19 GMT 2025
WHO-ATC R07AB07
Created by admin on Mon Mar 31 17:56:19 GMT 2025 , Edited by admin on Mon Mar 31 17:56:19 GMT 2025
WHO-VATC QR07AB07
Created by admin on Mon Mar 31 17:56:19 GMT 2025 , Edited by admin on Mon Mar 31 17:56:19 GMT 2025
Code System Code Type Description
CHEBI
53778
Created by admin on Mon Mar 31 17:56:19 GMT 2025 , Edited by admin on Mon Mar 31 17:56:19 GMT 2025
PRIMARY
NCI_THESAURUS
C74241
Created by admin on Mon Mar 31 17:56:19 GMT 2025 , Edited by admin on Mon Mar 31 17:56:19 GMT 2025
PRIMARY
MESH
D015765
Created by admin on Mon Mar 31 17:56:19 GMT 2025 , Edited by admin on Mon Mar 31 17:56:19 GMT 2025
PRIMARY
CAS
27469-53-0
Created by admin on Mon Mar 31 17:56:19 GMT 2025 , Edited by admin on Mon Mar 31 17:56:19 GMT 2025
PRIMARY
EPA CompTox
DTXSID4057899
Created by admin on Mon Mar 31 17:56:19 GMT 2025 , Edited by admin on Mon Mar 31 17:56:19 GMT 2025
PRIMARY
SMS_ID
100000087461
Created by admin on Mon Mar 31 17:56:19 GMT 2025 , Edited by admin on Mon Mar 31 17:56:19 GMT 2025
PRIMARY
FDA UNII
9A1222NBG4
Created by admin on Mon Mar 31 17:56:19 GMT 2025 , Edited by admin on Mon Mar 31 17:56:19 GMT 2025
PRIMARY
ChEMBL
CHEMBL1183717
Created by admin on Mon Mar 31 17:56:19 GMT 2025 , Edited by admin on Mon Mar 31 17:56:19 GMT 2025
PRIMARY
RXCUI
528
Created by admin on Mon Mar 31 17:56:19 GMT 2025 , Edited by admin on Mon Mar 31 17:56:19 GMT 2025
PRIMARY RxNorm
ECHA (EC/EINECS)
248-475-5
Created by admin on Mon Mar 31 17:56:19 GMT 2025 , Edited by admin on Mon Mar 31 17:56:19 GMT 2025
PRIMARY
DRUG BANK
DB01430
Created by admin on Mon Mar 31 17:56:19 GMT 2025 , Edited by admin on Mon Mar 31 17:56:19 GMT 2025
PRIMARY
WIKIPEDIA
ALMITRINE
Created by admin on Mon Mar 31 17:56:19 GMT 2025 , Edited by admin on Mon Mar 31 17:56:19 GMT 2025
PRIMARY
PUBCHEM
33887
Created by admin on Mon Mar 31 17:56:19 GMT 2025 , Edited by admin on Mon Mar 31 17:56:19 GMT 2025
PRIMARY
DRUG CENTRAL
127
Created by admin on Mon Mar 31 17:56:19 GMT 2025 , Edited by admin on Mon Mar 31 17:56:19 GMT 2025
PRIMARY
MERCK INDEX
m1564
Created by admin on Mon Mar 31 17:56:19 GMT 2025 , Edited by admin on Mon Mar 31 17:56:19 GMT 2025
PRIMARY Merck Index
INN
4123
Created by admin on Mon Mar 31 17:56:19 GMT 2025 , Edited by admin on Mon Mar 31 17:56:19 GMT 2025
PRIMARY
EVMPD
SUB05348MIG
Created by admin on Mon Mar 31 17:56:19 GMT 2025 , Edited by admin on Mon Mar 31 17:56:19 GMT 2025
PRIMARY
Related Record Type Details
Structure of ALMITRINE MESYLATE
SALT/SOLVATE -> PARENT
Related Record Type Details
Structure of ALMITRINE
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