ALMITRINE MESYLATE

Possibly Marketed Outside US

Details

Stereochemistry	ACHIRAL
Molecular Formula	C26H29F2N7.2CH4O3S
Molecular Weight	669.763
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CS(O)(=O)=O.CS(O)(=O)=O.FC1=CC=C(C=C1)C(N2CCN(CC2)C3=NC(NCC=C)=NC(NCC=C)=N3)C4=CC=C(F)C=C4

InChI

InChIKey=MRDBGMJEPGXQHJ-UHFFFAOYSA-N

InChI=1S/C26H29F2N7.2CH4O3S/c1-3-13-29-24-31-25(30-14-4-2)33-26(32-24)35-17-15-34(16-18-35)23(19-5-9-21(27)10-6-19)20-7-11-22(28)12-8-20;2*1-5(2,3)4/h3-12,23H,1-2,13-18H2,(H2,29,30,31,32,33);2*1H3,(H,2,3,4)

HIDE SMILES / InChI

Molecular Formula	C26H29F2N7
Molecular Weight	477.5522
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	CH4O3S
Molecular Weight	96.106
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/21412915 | https://www.ncbi.nlm.nih.gov/pubmed/3556128

Almitrine, a selective pulmonary vasoconstrictor and a respiratory stimulant that enhances respiration by acting as an agonist of peripheral chemoreceptors located on the carotid bodies. The drug increases arterial oxygen tension while decreasing arterial carbon dioxide tension in patients with chronic obstructive pulmonary disease. In combination with raubasine, it used under the brand, name Duxil for the treatment of age-related cerebral disorders and functional rehabilitation after stroke. In addition, Duxil has been considered as an alternative treatment for dementia, but because of the low methodological quality of included trials and the small number of trials, the obtained data did not provide sufficient evidence to support the routine use of this drug for the disease.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Sodium/potassium-transporting ATPase subunit alpha-1 16 Target ID: P05023\|\|\|Q9UJ20 Gene ID: 476.0 Gene Symbol: ATP1A1 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/2527061	Binding Agent 1076

PubMed

Title	Date	PubMed
Evaluation of Almitrine Infusion During Veno-Venous Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome in Adults.	2019-08	29337729
Almitrine-Raubasine combination for dementia.	2011-03-16	21412915
The neuronal guidance protein netrin-1 reduces alveolar inflammation in a porcine model of acute lung injury.	2010	20969752
Rescue strategies for refractory hypoxemia: a critical appraisal.	2009-11-26	20948686
Stability-indicating methods for the determination of a mixture of almitrine and raubasine by derivative spectrophotometry.	2009-06	20355207
Obesity hypoventilation syndrome.	2009-04	19561923
Anaesthesia for serial whole-lung lavage in a patient with severe pulmonary alveolar proteinosis: a case report.	2008-11-27	19038019
[Effect of long-time retention of scalp needle on the abilities of cognition, daily living activity and P300 in vascular dementia patients].	2008-10	19097507
Role of nitric oxide in management of acute respiratory distress syndrome.	2008-07	19561888
[Clinical investigation on electroacupuncture treatment of vascular dementia with "Xiusanzhen"].	2008-04	18630591
Current concepts in the management of hepatopulmonary syndrome.	2008	19183751
Association between inflammatory mediators and response to inhaled nitric oxide in a model of endotoxin-induced lung injury.	2008	18954441
[Combination of thiotropium bromide with almitrine and pulmonary rehabilitation in the treatment of patients with chronic obstructive pulmonary disease].	2008	18441680
Low-tidal-volume ventilation.	2007-12-13	18077819
[Observation on therapeutic effect of puncturing with needles in alignment at the hairline region on vascular dementia].	2007-06	17663102
[Clinical research of effect of Yishen Yangnao capsule on vascular dementia].	2007-04	17608233
[A clinical study on a randomized, double-blind control of Chinese medicine granules in treatment of vascular dementia].	2006-10	17225547
[The effects of antidepressant treatment on efficacy of antihypertensive therapy in elderly hypertension].	2006-08	17074147
[Effect of prepared Polygonum multiflorum on striatum extracellular acetylcholine and choline in rats of intracerebral perfusion with sodium azide].	2006-05	17048685
[Research of kingsbrain on improving the learning and memory ability of MCAO rats].	2006-03	16722378
An anesthesiologist's guide to hypoxic pulmonary vasoconstriction: implications for managing single-lung anesthesia and atelectasis.	2006-02	16547431
Low- vs high-dose almitrine combined with nitric oxide to prevent hypoxia during open-chest one-lung ventilation.	2005-09	16024585
Medroxyprogesterone improves nocturnal breathing in postmenopausal women with chronic obstructive pulmonary disease.	2005-04-04	15807890
[Effects of Tianzhi Keli on extracellular acetylcholine and catecholamine levels in striatum of rats with neuromitochondrial impairment].	2005-01	15714821
Clinical review: Independent lung ventilation in critical care.	2005	16356244
Assessment of the therapeutic activity of a combination of almitrine and raubasine on functional rehabilitation following ischaemic stroke.	2004-03	15025850
Treatment of hypoxemia during one-lung ventilation using intravenous almitrine.	2004-03	14980903
pO2 - Do we treat the right thing?	2003-12-11	14665766
Orthodeoxia--an uncommon presentation following bilateral thoracic sympathectomy.	2003-10	14601286
Long-term effects of almitrine bismesylate in COPD patients with chronic hypoxaemia.	2003-06	12814142
Selective pulmonary vasodilation in acute respiratory distress syndrome.	2003-04	12682462
[Gas exchange in acute respiratory distress syndrome].	2003	12793087
Jian Nao Ning for treatment of memory impairment in patients with mild or moderate multi-infarct dementia.	2002-12	16579082
Primary alveolar hypoventilation and response to the respiratory stimulant almitrine.	2002-12	12512759
Effect of position, nitric oxide, and almitrine on lung perfusion in a porcine model of acute lung injury.	2002-12	12391113
Vascular pharmacology of acute lung injury and acute respiratory distress syndrome.	2002-11	12747964
Effects of almitrine bismesylate on arterial blood gases in patients with chronic obstructive pulmonary disease and moderate hypoxaemia: a multicentre, randomised, double-blind, placebo-controlled study.	2002-05-22	12915747
Effect of ventilatory drive on carbon dioxide sensitivity below eupnea during sleep.	2002-05-01	11991874
Treatment of hypoxaemia during one-lung ventilation with almitrine.	2002-04-13	11965308
The effects of intravenous almitrine on oxygenation and hemodynamics during one-lung ventilation.	2002-04	11916780
[Effect of almitrine/raubasine on cerebral metabolism in the elderly].	2002-03-30	11984975
An investigation into the mechanism of action of almitrine on isolated rat diaphragm muscle fatigue.	2002	12169748
Effects of almitrine on diaphragm contractile properties in young and old rats.	2002	11844967
High or low doses of almitrine bismesylate in ARDS patients responding to inhaled NO and receiving norepinephrine?	2001-11	11810116
Oxygen sensitive chemoreceptors in the first gill arch of the tadpole, Rana catesbeiana.	2001-11	11760099
[Comparative changes in PaO2 in moderately hypoxemic COPD patients treated with almitrine versus placebo for one year].	2001-09	11787328
The oxygenation variations related to prone positioning during mechanical ventilation: a clinical comparison between ARDS and non-ARDS hypoxemic patients.	2001-08	11511948
Biliary drug lithiasis: dipyridamole gallstones.	1992-11-28	1360065
Peripheral neuropathy in patients treated with almitrine dimesylate.	1985-06-01	2860446
[Competitive study of the effects of naloxone and of almitrine on fentanyl analgesia in the anesthetized dog: effects on the muzzle opening reflex and blood gases].	1980	6110396

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:34:00 GMT 2025` Edited by `admin` on `Mon Mar 31 17:34:00 GMT 2025`
Record UNII	6RY6V6XM8T
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ALMITRINE DIMESILATE

Preferred Name

English

ALMITRINE MESYLATE

Official Name

English

6-4-(BIS(4-FLUOROPHENYL)METHYL)-1-PIPERAZINYL)-N,N'-DI-2-PROPENYL-1,3,5-TRIAZINE-2,4-DIAMINE DIMETHANESULPHONATE

Common Name

English

ALMITRINE BISMESYLATE

Common Name

English

2,4-BIS(ALLYLAMINO)-6-(4-(BIS(P-FLUOROPHENYL)METHYL)-1-PIPERAZINYL)-S-TRIAZINE DIMETHANESULFONATE

Common Name

English

ALMITRINE MESILATE

Common Name

English

ALMITRINE DIMESYLATE

Common Name

English

S-2620

Code

English

ALMITRINE DIMETHANESULFONATE

Common Name

English

ALMITRINE DIMETHANESULFONATE [MI]

Common Name

English

Almitrine dimesilate [WHO-DD]

Common Name

English

2,4-BIS(ALLYLAMINO)-6-(4-(BIS(P-FLUOROPHENYL)METHYL)-1-PIPERAZINYL)-S-TRIAZINE DIMETHANESULPHONATE

Common Name

English

ALMITRINE BISMESILATE

Common Name

English

ALMITRINE DIMESILATE [MART.]

Common Name

English

6-4-(BIS(4-FLUOROPHENYL)METHYL)-1-PIPERAZINYL)-N,N'-DI-2-PROPENYL-1,3,5-TRIAZINE-2,4-DIAMINE DIMETHANESULFONATE

Common Name

English

ALMITRINE MESYLATE [USAN]

Common Name

English

VECTARION

Brand Name

English

Classification Tree Code System Code

NCI_THESAURUS

C47795