U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C26H29F2N7.2CH4O3S
Molecular Weight 669.763
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ALMITRINE MESYLATE

SMILES

CS(O)(=O)=O.CS(O)(=O)=O.FC1=CC=C(C=C1)C(N2CCN(CC2)C3=NC(NCC=C)=NC(NCC=C)=N3)C4=CC=C(F)C=C4

InChI

InChIKey=MRDBGMJEPGXQHJ-UHFFFAOYSA-N
InChI=1S/C26H29F2N7.2CH4O3S/c1-3-13-29-24-31-25(30-14-4-2)33-26(32-24)35-17-15-34(16-18-35)23(19-5-9-21(27)10-6-19)20-7-11-22(28)12-8-20;2*1-5(2,3)4/h3-12,23H,1-2,13-18H2,(H2,29,30,31,32,33);2*1H3,(H,2,3,4)

HIDE SMILES / InChI
Molecular Formula CH4O3S
Molecular Weight 96.106
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula C26H29F2N7
Molecular Weight 477.5522
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Almitrine, a selective pulmonary vasoconstrictor and a respiratory stimulant that enhances respiration by acting as an agonist of peripheral chemoreceptors located on the carotid bodies. The drug increases arterial oxygen tension while decreasing arterial carbon dioxide tension in patients with chronic obstructive pulmonary disease. In combination with raubasine, it used under the brand, name Duxil for the treatment of age-related cerebral disorders and functional rehabilitation after stroke. In addition, Duxil has been considered as an alternative treatment for dementia, but because of the low methodological quality of included trials and the small number of trials, the obtained data did not provide sufficient evidence to support the routine use of this drug for the disease.

Approval Year

Unknown
139594
Targets

Targets

Primary TargetPharmacologyConditionPotency
Sodium/potassium-transporting ATPase subunit alpha-1
16
Target ID: P05023|||Q9UJ20
Gene ID: 476.0
Gene Symbol: ATP1A1
Target Organism: Homo sapiens (Human)
Binding Agent
1064
PubMed

PubMed

TitleDatePubMed
[Competitive study of the effects of naloxone and of almitrine on fentanyl analgesia in the anesthetized dog: effects on the muzzle opening reflex and blood gases].
1980
Peripheral neuropathy in patients treated with almitrine dimesylate.
1985 Jun 1
Association of oral almitrine and medroxyprogesterone acetate: effect on arterial blood gases in chronic obstructive pulmonary disease.
2001 Jul
Effects of combined high-dose partial liquid ventilation and almitrine on pulmonary gas exchange and hemodynamics in an animal model of acute lung injury.
2001 Mar
Oxygen sensitive chemoreceptors in the first gill arch of the tadpole, Rana catesbeiana.
2001 Nov
Effect of ventilatory drive on carbon dioxide sensitivity below eupnea during sleep.
2002 May 1
[Gas exchange in acute respiratory distress syndrome].
2003
Orthodeoxia--an uncommon presentation following bilateral thoracic sympathectomy.
2003 Oct
Treatment of hypoxemia during one-lung ventilation using intravenous almitrine.
2004 Mar
Medroxyprogesterone improves nocturnal breathing in postmenopausal women with chronic obstructive pulmonary disease.
2005 Apr 4
Low- vs high-dose almitrine combined with nitric oxide to prevent hypoxia during open-chest one-lung ventilation.
2005 Sep
[The effects of antidepressant treatment on efficacy of antihypertensive therapy in elderly hypertension].
2006 Aug
Low-tidal-volume ventilation.
2007 Dec 13
Obesity hypoventilation syndrome.
2009 Apr
Stability-indicating methods for the determination of a mixture of almitrine and raubasine by derivative spectrophotometry.
2009 Jun
Rescue strategies for refractory hypoxemia: a critical appraisal.
2009 Nov 26
The neuronal guidance protein netrin-1 reduces alveolar inflammation in a porcine model of acute lung injury.
2010
Almitrine-Raubasine combination for dementia.
2011 Mar 16
Substance Class Chemical
Created
by admin
on Fri Dec 15 14:59:04 UTC 2023
Edited
by admin
on Fri Dec 15 14:59:04 UTC 2023
Record UNII
6RY6V6XM8T
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ALMITRINE MESYLATE
USAN  
USAN  
Official Name English
6-4-(BIS(4-FLUOROPHENYL)METHYL)-1-PIPERAZINYL)-N,N'-DI-2-PROPENYL-1,3,5-TRIAZINE-2,4-DIAMINE DIMETHANESULPHONATE
Common Name English
ALMITRINE BISMESYLATE
Common Name English
2,4-BIS(ALLYLAMINO)-6-(4-(BIS(P-FLUOROPHENYL)METHYL)-1-PIPERAZINYL)-S-TRIAZINE DIMETHANESULFONATE
Common Name English
ALMITRINE MESILATE
Common Name English
ALMITRINE DIMESILATE
MART.   WHO-DD  
Common Name English
ALMITRINE DIMESYLATE
Common Name English
S-2620
Code English
ALMITRINE DIMETHANESULFONATE
MI  
Common Name English
ALMITRINE DIMETHANESULFONATE [MI]
Common Name English
Almitrine dimesilate [WHO-DD]
Common Name English
2,4-BIS(ALLYLAMINO)-6-(4-(BIS(P-FLUOROPHENYL)METHYL)-1-PIPERAZINYL)-S-TRIAZINE DIMETHANESULPHONATE
Common Name English
ALMITRINE BISMESILATE
Common Name English
ALMITRINE DIMESILATE [MART.]
Common Name English
6-4-(BIS(4-FLUOROPHENYL)METHYL)-1-PIPERAZINYL)-N,N'-DI-2-PROPENYL-1,3,5-TRIAZINE-2,4-DIAMINE DIMETHANESULFONATE
Common Name English
ALMITRINE MESYLATE [USAN]
Common Name English
VECTARION
Brand Name English
Classification Tree Code System Code
NCI_THESAURUS C47795
Created by admin on Fri Dec 15 14:59:04 UTC 2023 , Edited by admin on Fri Dec 15 14:59:04 UTC 2023
Code System Code Type Description
FDA UNII
6RY6V6XM8T
Created by admin on Fri Dec 15 14:59:04 UTC 2023 , Edited by admin on Fri Dec 15 14:59:04 UTC 2023
PRIMARY
MERCK INDEX
m1564
Created by admin on Fri Dec 15 14:59:04 UTC 2023 , Edited by admin on Fri Dec 15 14:59:04 UTC 2023
PRIMARY Merck Index
ECHA (EC/EINECS)
249-726-1
Created by admin on Fri Dec 15 14:59:04 UTC 2023 , Edited by admin on Fri Dec 15 14:59:04 UTC 2023
PRIMARY
CHEBI
53779
Created by admin on Fri Dec 15 14:59:04 UTC 2023 , Edited by admin on Fri Dec 15 14:59:04 UTC 2023
PRIMARY
NCI_THESAURUS
C79962
Created by admin on Fri Dec 15 14:59:04 UTC 2023 , Edited by admin on Fri Dec 15 14:59:04 UTC 2023
PRIMARY
ChEMBL
CHEMBL1183717
Created by admin on Fri Dec 15 14:59:04 UTC 2023 , Edited by admin on Fri Dec 15 14:59:04 UTC 2023
PRIMARY
USAN
W-114
Created by admin on Fri Dec 15 14:59:04 UTC 2023 , Edited by admin on Fri Dec 15 14:59:04 UTC 2023
PRIMARY
SMS_ID
100000078857
Created by admin on Fri Dec 15 14:59:04 UTC 2023 , Edited by admin on Fri Dec 15 14:59:04 UTC 2023
PRIMARY
CAS
29608-49-9
Created by admin on Fri Dec 15 14:59:04 UTC 2023 , Edited by admin on Fri Dec 15 14:59:04 UTC 2023
PRIMARY
RXCUI
529
Created by admin on Fri Dec 15 14:59:04 UTC 2023 , Edited by admin on Fri Dec 15 14:59:04 UTC 2023
PRIMARY RxNorm
EPA CompTox
DTXSID5057703
Created by admin on Fri Dec 15 14:59:04 UTC 2023 , Edited by admin on Fri Dec 15 14:59:04 UTC 2023
PRIMARY
DRUG BANK
DBSALT000916
Created by admin on Fri Dec 15 14:59:04 UTC 2023 , Edited by admin on Fri Dec 15 14:59:04 UTC 2023
PRIMARY
EVMPD
SUB00363MIG
Created by admin on Fri Dec 15 14:59:04 UTC 2023 , Edited by admin on Fri Dec 15 14:59:04 UTC 2023
PRIMARY
PUBCHEM
6918543
Created by admin on Fri Dec 15 14:59:04 UTC 2023 , Edited by admin on Fri Dec 15 14:59:04 UTC 2023
PRIMARY
Related Record Type Details
Structure of ALMITRINE
PARENT -> SALT/SOLVATE
Related Record Type Details
Structure of ALMITRINE
ACTIVE MOIETY
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966