Sonesitatug Vedotin

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 11:38:21 GMT 2025` Edited by `admin` on `Wed Apr 02 11:38:21 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY CONJUGATE
Protein Sub Type	IGG1\|KAPPA
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	96ZG83EF42
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Sonesitatug Vedotin

Official Name

English

An anti-Claudin 18.2 monoclonal antibody conjugated with MMAE payload

Preferred Name

English

immunoglobulin G1-kappa, anti-[Homo sapiens CLDN18 (claudin 18, claudin-18, surfactant associated protein J, SFTPJ) isoform 2], humanized monoclonal antibody, conjugated on an average of four cysteinyl residues to vedotin, comprising a cleavable linker a

Common Name

English

Immunoglobulin G1, anti-(human claudin CLDN18) (human-Mus musculus monoclonal CM311 ?1-chain), disulfide with human-Mus musculus monoclonal CM311 ?-chain, dimer, thioether with N-[[[4-[[N-[6-(3-mercapto-2,5-dioxo-1-pyrrolidinyl)-1-oxohexyl]-L-valyl-N5-(a

Common Name

English

sonesitatug vedotin [INN]

Common Name

English

H-gamma1 heavy chain humanized (1-448) [VH (Homo sapiens IGHV4-59*11 (94.8%) -(IGHD) -IGHJ4*01 (92.9%), CDR-IMGT [9.7.11] (26-34.52-58.97-107)) (1-118) -Homo sapiens IGHG1*03 (100%) G1m3, nG1m1 CH1 R120, CH3 E12, M14 (CH1 R120 (215) (119-216), hinge 1-15

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

871122