Sonesitatug Vedotin

Investigational

Approval Year

Substance Class	Protein
Protein Type	MONOCLONAL ANTIBODY CONJUGATE
Protein Sub Type	IGG1\|KAPPA
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	96ZG83EF42
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Sonesitatug Vedotin

Official Name

English

An anti-Claudin 18.2 monoclonal antibody conjugated with MMAE payload

Preferred Name

English

immunoglobulin G1-kappa, anti-[Homo sapiens CLDN18 (claudin 18, claudin-18, surfactant associated protein J, SFTPJ) isoform 2], humanized monoclonal antibody, conjugated on an average of four cysteinyl residues to vedotin, comprising a cleavable linker a

Common Name

English

Immunoglobulin G1, anti-(human claudin CLDN18) (human-Mus musculus monoclonal CM311 ?1-chain), disulfide with human-Mus musculus monoclonal CM311 ?-chain, dimer, thioether with N-[[[4-[[N-[6-(3-mercapto-2,5-dioxo-1-pyrrolidinyl)-1-oxohexyl]-L-valyl-N5-(a

Common Name

English

sonesitatug vedotin [INN]

Common Name

English

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Classification Tree

Code System

Code

Designated

FDA ORPHAN DRUG

871122

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Code System

Code

Type

Description

SMS_ID

300000052801

PRIMARY

INN

12846

PRIMARY

NCI_THESAURUS

C180413

PRIMARY

CAS

2813237-93-1

PRIMARY

FDA UNII

96ZG83EF42

PRIMARY

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Subunit 0

Subunit 1

Subunit 2

Subunit 3

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From	To
1_22	1_96
2_22	2_96
2_145	2_201
2_221	4_220
2_262	2_322

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Glycosylation Type

MAMMALIAN

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Glycosylation Link Type	Site
N	1_298
N	2_298

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Related Record

Type

Details


					96ZG83EF42

Sonesitatug Vedotin

ACTIVE MOIETY

Amount:

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Structural Modifications

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Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION		RESIDUE_SPECIFIC	C	Amount: MOL RATIO [3.3 to 4.3] (average)	Cysteinyl vedotin	6603L01WUR
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS			PIDOLIC ACID	SZB83O1W42
AMINO ACID REMOVAL	[1_448] [2_448]	C-TERMINUS		Amount:	LYSINE	K3Z4F929H6

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Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL	ESTIMATED C6518H10062O2054N1706S40
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL	151480.8 DALTONS (average) Deglycosylated, -K. proglu- DAR4

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