CLODANOLENE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C14H9Cl2N3O3
Molecular Weight	338.146
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

ClC1=C(Cl)C=C(C=C1)C2=CC=C(O2)\C=N\N3CC(=O)NC3=O

InChI

InChIKey=HIQONTNPQNNMST-UBKPWBPPSA-N

InChI=1S/C14H9Cl2N3O3/c15-10-3-1-8(5-11(10)16)12-4-2-9(22-12)6-17-19-7-13(20)18-14(19)21/h1-6H,7H2,(H,18,20,21)/b17-6+

HIDE SMILES / InChI

Molecular Formula	C14H9Cl2N3O3
Molecular Weight	338.146
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Description
Sources: https://bjanaesthesia.org/article/S0007-0912(17)43363-0/pdf | https://www.ncbi.nlm.nih.gov/pubmed/582696

Clodanolene is a skeletal muscle contraction antagonist, closely related to dantrolene sodium. The drug has no measurable direct effect on the peripheral or central nervous systems. In a mouse of muscle spasticity (Straub-tail mouse), clodanolene induced skeletal muscle relaxation more effectively than neuromuscular blocking agents, local anesthetics, or centrally-acting muscle relaxants. Indirect evidence indicates clodanolene acts on caffeine-sensitive calcium stores in the muscle cells.

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:24:58 GMT 2023` Edited by `admin` on `Fri Dec 15 15:24:58 GMT 2023`
Record UNII	96L9G9BL3X
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CLODANOLENE

Official Name

English

NSC-186557

Code

English

2,4-IMIDAZOLIDINEDIONE, 1-(((5-(3,4-DICHLOROPHENYL)-2-FURANYL)METHYLENE)AMINO)-

Systematic Name

English

F-413

Code

English

CLODANOLENE [USAN]

Common Name

English

clodanolene [INN]

Common Name

English

1-[[5-(3,4-Dichlorophenyl)furfurylidene]amino]hydantoin

Systematic Name

English

F-605 FREE ACID

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C29696