CHLORPROETHAZINE

Possibly Marketed Outside US

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H23ClN2S
Molecular Weight	346.917
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCN(CC)CCCN1C2=C(SC3=C1C=C(Cl)C=C3)C=CC=C2

InChI

InChIKey=DBOUGBAQLIXZLV-UHFFFAOYSA-N

InChI=1S/C19H23ClN2S/c1-3-21(4-2)12-7-13-22-16-8-5-6-9-18(16)23-19-11-10-15(20)14-17(19)22/h5-6,8-11,14H,3-4,7,12-13H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C19H23ClN2S
Molecular Weight	346.917
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.drugs.com/international/chlorproethazine.html | https://www.ncbi.nlm.nih.gov/pubmed/13958556 | https://www.ncbi.nlm.nih.gov/pubmed/5324919 | https://www.ncbi.nlm.nih.gov/pubmed/18201351

Chlorproethazine (Neuriplege) is a neuroleptic, antipsychotic and muscle relaxant. Neuriplege® cream was available as a non‐prescription medication in France until its withdrawal from the market by regulatory authorities in January 2007. Neuriplege caused phototoxicity and photocontact allergy.

Originator

Approval Year

PubMed

Title	Date	PubMed
Hypothermia increases interleukin-6 and interleukin-10 in juvenile endotoxemic mice.	2010-01	19602992
Toxic effects of chlorpromazine on Carassius auratus and its oxidative stress.	2008-11	18941986
Comparative effects of cationic triarylmethane, phenoxazine and phenothiazine dyes on horse serum butyrylcholinesterase.	2008-10-15	18656440
Photocontact allergic and phototoxic studies of chlorproethazine.	2008-02	18201351
Combined quinacrine and chlorpromazine therapy in fatal familial insomnia.	2004-08-21	15319710
Contact sensitization to chlorproethazine can induce persistent light reaction and cross-photoreactions to other phenothiazines.	2001-06	11417527

Patents

Substance Class	Chemical Created by `admin` on `Wed Apr 02 08:28:51 GMT 2025` Edited by `admin` on `Wed Apr 02 08:28:51 GMT 2025`
Record UNII	960NX27Z07
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CHLORPROETHAZINE

Official Name

English

CHLORPROETHAZINE [MI]

Preferred Name

English

chlorproethazine [INN]

Common Name

English

Chlorproethazine [WHO-DD]

Common Name

English

2-CHLORO-10-(3-DIETHYLAMINOPROPYL)PHENOTHIAZINE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C66880