CHLORPROETHAZINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H23ClN2S
Molecular Weight	346.917
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCN(CC)CCCN1C2=CC(Cl)=CC=C2SC3=C1C=CC=C3

InChI

InChIKey=DBOUGBAQLIXZLV-UHFFFAOYSA-N

InChI=1S/C19H23ClN2S/c1-3-21(4-2)12-7-13-22-16-8-5-6-9-18(16)23-19-11-10-15(20)14-17(19)22/h5-6,8-11,14H,3-4,7,12-13H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C19H23ClN2S
Molecular Weight	346.917
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.drugs.com/international/chlorproethazine.html | https://www.ncbi.nlm.nih.gov/pubmed/13958556 | https://www.ncbi.nlm.nih.gov/pubmed/5324919 | https://www.ncbi.nlm.nih.gov/pubmed/18201351

Chlorproethazine (Neuriplege) is a neuroleptic, antipsychotic and muscle relaxant. Neuriplege® cream was available as a non‐prescription medication in France until its withdrawal from the market by regulatory authorities in January 2007. Neuriplege caused phototoxicity and photocontact allergy.

Originator

Approval Year

PubMed

Title	Date	PubMed
Contact sensitization to chlorproethazine can induce persistent light reaction and cross-photoreactions to other phenothiazines.	2001 Jun	11417527
Combined quinacrine and chlorpromazine therapy in fatal familial insomnia.	2004 Jul-Aug	15319710
Photocontact allergic and phototoxic studies of chlorproethazine.	2008 Feb	18201351
Toxic effects of chlorpromazine on Carassius auratus and its oxidative stress.	2008 Nov	18941986
Comparative effects of cationic triarylmethane, phenoxazine and phenothiazine dyes on horse serum butyrylcholinesterase.	2008 Oct 15	18656440
Hypothermia increases interleukin-6 and interleukin-10 in juvenile endotoxemic mice.	2010 Jan	19602992

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 16:52:21 GMT 2023` Edited by `admin` on `Sat Dec 16 16:52:21 GMT 2023`
Record UNII	960NX27Z07
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CHLORPROETHAZINE

Official Name

English

chlorproethazine [INN]

Common Name

English

Chlorproethazine [WHO-DD]

Common Name

English

CHLORPROETHAZINE [MI]

Common Name

English

2-CHLORO-10-(3-DIETHYLAMINOPROPYL)PHENOTHIAZINE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C66880