TENILOXAZINE

Details

Stereochemistry	RACEMIC
Molecular Formula	C16H19NO2S
Molecular Weight	289.393
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C(OC1=CC=CC=C1CC2=CC=CS2)C3CNCCO3

InChI

InChIKey=OILWWIVKIDXCIB-UHFFFAOYSA-N

InChI=1S/C16H19NO2S/c1-2-6-16(19-12-14-11-17-7-8-18-14)13(4-1)10-15-5-3-9-20-15/h1-6,9,14,17H,7-8,10-12H2

HIDE SMILES / InChI

Molecular Formula	C16H19NO2S
Molecular Weight	289.393
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3593624 | https://www.ncbi.nlm.nih.gov/pubmed/31211282 | https://adisinsight.springer.com/drugs/800000566

Teniloxazine (also known as sulfoxazine or sufoxazine or Y 8894) was developed as an antidepressant. Teniloxazine belongs to the selective norepinephrine reuptake inhibitors (NRIs) and was studied for the treatment of the major depressive disorder. Clinical trials have shown that 50 mg of the drug lacked the anticholinergic, sedative and cardiovascular effects. In the elderly, some effects were recognized, in part, due to pharmacokinetic alteration. In addition, teniloxazine was studied for patients with Alzheimer's disease, however, doesn’t exist any development report for this study.

Originator

Approval Year

PubMed

Title	Date	PubMed
The emergence of new antidepressants for clinical use: Agomelatine paradox versus other novel agents.	2019-06	31211282
[Pharmacological studies on Y-8894. (IV). Ameliorative effect on a cerebral energy metabolism disorder induced by KCN].	1986-11	3817653
[Pharmacological studies on Y-8894. (III). Its effect on the abnormal electrocorticogram induced by destruction of the internal capsule].	1986-10	3491778
[Pharmacological studies on sufoxazine (Y-8894). (II). Anti-anoxic effect].	1985-10	4085932
[Pharmacological studies on sufoxazine (Y-8894). (I) Effects on experimental amnesia in mice].	1985-02	2859238

Sample Use Guides

In Vivo Use Guide

Y-8894 (TENILOXAZINE) 50 mg

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:35:27 GMT 2025` Edited by `admin` on `Mon Mar 31 18:35:27 GMT 2025`
Record UNII	95Q6WNP25P
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TENILOXAZINE

Official Name

English

TENILOXAZINE [MART.]

Preferred Name

English

teniloxazine [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C265