Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C16H19NO2S.C4H4O4 |
| Molecular Weight | 405.465 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)\C=C/C(O)=O.C(OC1=CC=CC=C1CC2=CC=CS2)C3CNCCO3
InChI
InChIKey=ONQAJVWRFPPADI-BTJKTKAUSA-N
InChI=1S/C16H19NO2S.C4H4O4/c1-2-6-16(19-12-14-11-17-7-8-18-14)13(4-1)10-15-5-3-9-20-15;5-3(6)1-2-4(7)8/h1-6,9,14,17H,7-8,10-12H2;1-2H,(H,5,6)(H,7,8)/b;2-1-
| Molecular Formula | C4H4O4 |
| Molecular Weight | 116.0722 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Optical Activity | NONE |
| Molecular Formula | C16H19NO2S |
| Molecular Weight | 289.393 |
| Charge | 0 |
| Count |
|
| Stereochemistry | RACEMIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Optical Activity | ( + / - ) |
Teniloxazine (also known as sulfoxazine or sufoxazine or Y 8894) was developed as an antidepressant. Teniloxazine belongs to the selective norepinephrine reuptake inhibitors (NRIs) and was studied for the treatment of the major depressive disorder. Clinical trials have shown that 50 mg of the drug lacked the anticholinergic, sedative and cardiovascular effects. In the elderly, some effects were recognized, in part, due to pharmacokinetic alteration. In addition, teniloxazine was studied for patients with Alzheimer's disease, however, doesn’t exist any development report for this study.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| The emergence of new antidepressants for clinical use: Agomelatine paradox versus other novel agents. | 2019-06 |
|
| [Pharmacological studies on Y-8894. (IV). Ameliorative effect on a cerebral energy metabolism disorder induced by KCN]. | 1986-11 |
|
| [Pharmacological studies on Y-8894. (III). Its effect on the abnormal electrocorticogram induced by destruction of the internal capsule]. | 1986-10 |
|
| [Pharmacological studies on sufoxazine (Y-8894). (II). Anti-anoxic effect]. | 1985-10 |
|
| [Pharmacological studies on sufoxazine (Y-8894). (I) Effects on experimental amnesia in mice]. | 1985-02 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 21:46:19 GMT 2025
by
admin
on
Mon Mar 31 21:46:19 GMT 2025
|
| Record UNII |
1BY0CJ6QWX
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Preferred Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
6438129
Created by
admin on Mon Mar 31 21:46:19 GMT 2025 , Edited by admin on Mon Mar 31 21:46:19 GMT 2025
|
PRIMARY | |||
|
62473-80-7
Created by
admin on Mon Mar 31 21:46:19 GMT 2025 , Edited by admin on Mon Mar 31 21:46:19 GMT 2025
|
PRIMARY | |||
|
1BY0CJ6QWX
Created by
admin on Mon Mar 31 21:46:19 GMT 2025 , Edited by admin on Mon Mar 31 21:46:19 GMT 2025
|
PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
|
PARENT -> SALT/SOLVATE |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
|
ACTIVE MOIETY |