1-(3-CHLOROPHENYL)BIGUANIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C8H10ClN5
Molecular Weight	211.652
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of 1-(3-CHLOROPHENYL)BIGUANIDE

Structure Search

SMILES

NC(=N)NC(=N)NC1=CC(Cl)=CC=C1

InChI

InChIKey=DIHXJZHAIHGSAW-UHFFFAOYSA-N

InChI=1S/C8H10ClN5/c9-5-2-1-3-6(4-5)13-8(12)14-7(10)11/h1-4H,(H6,10,11,12,13,14)

HIDE SMILES / InChI

Molecular Formula	C8H10ClN5
Molecular Weight	211.652
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Alpha-2A adrenergic receptor 26 Target ID: Q01338 Gene ID: NA Gene Symbol: Adra2a Target Organism: Mus musculus (Mouse) Sources: https://www.ncbi.nlm.nih.gov/pubmed/7908122	Antagonist 2778
Serotonin 3 (5-HT3) receptor 59 Target ID: CHEMBL2111332 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25541413 \| https://www.ncbi.nlm.nih.gov/pubmed/23810831	Positive Allosteric Modulator 179		1.02 µM [EC50]

PubMed

Title	Date	PubMed
Molecular cloning, functional expression, and pharmacological characterization of 5-hydroxytryptamine3 receptor cDNA and its splice variants from guinea pig.	1998 Feb	9463477
Evidence for 5-HT(1B/1D) and 5-HT(2A) receptors mediating constriction of the canine internal carotid circulation.	2001 Mar	11226128
Characterization of discriminative stimulus effects of the neuroactive steroid pregnanolone.	2001 May	11303034
Serotonin(3) receptor stimulation in the nucleus tractus solitarii activates non-catecholaminergic neurons in the rat ventrolateral medulla.	2002	12088752
The nature of the acetylcholine and 5-hydroxytryptamine receptors in buccal smooth muscle of the pest slug Deroceras reticulatum.	2002 Apr	11919705
Central 5-HT3 receptor stimulation by m-CPBG increases blood glucose in rats.	2002 Feb	11972287
Dopamine and serotonin receptors mediating contractions of the snail, Helix pomatia, salivary duct.	2003	12573719
A distinct distribution of functional presynaptic 5-HT receptor subtypes on GABAergic nerve terminals projecting to single hippocampal CA1 pyramidal neurons.	2003 Jun	12763095
Conformationally-restricted analogues and partition coefficients of the 5-HT3 serotonin receptor ligands meta-chlorophenylbiguanide (mCPBG) and meta-chlorophenylguanidine (mCPG).	2003 Mar 24	12643925
Excitatory action of prostanoids on the ferret isolated vagus nerve preparation.	2004 Apr 26	15102531
Serotonin type 3 receptors modulate the aggression-stimulating effects of adolescent cocaine exposure in Syrian hamsters (Mesocricetus auratus).	2004 Oct	15506892
Acetaminophen: a central analgesic drug that involves a spinal tropisetron-sensitive, non-5-HT(3) receptor-mediated effect.	2004 Sep	15322266
Involvement of spinal serotonin receptors in the regulation of intraspinal acetylcholine release.	2005 Feb 21	15733547
The loop C region of the murine 5-HT3A receptor contributes to the differential actions of 5-hydroxytryptamine and m-chlorophenylbiguanide.	2005 Jun 28	15966738
Antidepressants inhibit P2X4 receptor function: a possible involvement in neuropathic pain relief.	2009 Apr 23	19389225
Activation of serotonin 3 receptors changes in vivo auditory responses in the mouse inferior colliculus.	2009 May	19236912

Substance Class	Chemical Created by `admin` on `Fri Dec 15 19:39:47 UTC 2023` Edited by `admin` on `Fri Dec 15 19:39:47 UTC 2023`
Record UNII	910A4X901V
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

1-(3-CHLOROPHENYL)BIGUANIDE

Systematic Name

English

M-CHLOROPHENYLBIGUANIDE

Systematic Name

English

Code System Code Type Description

WIKIPEDIA

Chlorophenylbiguanide