1-(3-CHLOROPHENYL)BIGUANIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C8H10ClN5
Molecular Weight	211.652
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of 1-(3-CHLOROPHENYL)BIGUANIDE

Structure Search

SMILES

NC(=N)NC(=N)NC1=CC(Cl)=CC=C1

InChI

InChIKey=DIHXJZHAIHGSAW-UHFFFAOYSA-N

InChI=1S/C8H10ClN5/c9-5-2-1-3-6(4-5)13-8(12)14-7(10)11/h1-4H,(H6,10,11,12,13,14)

HIDE SMILES / InChI

Molecular Formula	C8H10ClN5
Molecular Weight	211.652
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Alpha-2A adrenergic receptor 26 Target ID: Q01338 Gene ID: NA Gene Symbol: Adra2a Target Organism: Mus musculus (Mouse) Sources: https://www.ncbi.nlm.nih.gov/pubmed/7908122	Antagonist 2778
Serotonin 3 (5-HT3) receptor 59 Target ID: CHEMBL2111332 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25541413 \| https://www.ncbi.nlm.nih.gov/pubmed/23810831	Positive Allosteric Modulator 179		1.02 µM [EC50]

PubMed

Title	Date	PubMed
Pharmacological profile of YM-31636, a novel 5-HT3 receptor agonist, in vitro.	2000 Dec 8	11104834
Cloning, expression, and characterization of ferret 5-HT(3) receptor subunit.	2000 Jul 7	10884508
Serotonin increases the incidence of primary afferent-evoked long-term depression in rat deep dorsal horn neurons.	2001 May	11353003
Characterization of discriminative stimulus effects of the neuroactive steroid pregnanolone.	2001 May	11303034
Different effects of 5-HT receptor agonists on operant response in rats under DRL 10-s and DRL 30-s schedules.	2001 Oct	11699570
The nature of the acetylcholine and 5-hydroxytryptamine receptors in buccal smooth muscle of the pest slug Deroceras reticulatum.	2002 Apr	11919705
Central 5-HT3 receptor stimulation by m-CPBG increases blood glucose in rats.	2002 Feb	11972287
Serotonin induces tonic firing in layer V pyramidal neurons of rat prefrontal cortex during postnatal development.	2003 Apr 15	12716945
Action of 5-HT3 receptor antagonists and dexamethasone to modify cisplatin-induced emesis in Suncus murinus (house musk shrew).	2003 Jul 4	12860482
Subunit rotation models activation of serotonin 5-HT3AB receptors by agonists.	2004 Oct	15849995
Effects of quipazine and m-chlorophenylbiguanide (m-CPBG) on the discrimination of durations: evidence for the involvement of 5-HT2A but not 5-HT3 receptors.	2005 Feb	15706137
Serotonin type 3 receptors stimulate offensive aggression in Syrian hamsters.	2005 Jan 6	15474647
Effects of quipazine and m-chlorophenylbiguanide (m-CPBG) on temporal differentiation: evidence for the involvement of 5-HT2A but not 5-HT3 receptors in interval timing behaviour.	2005 Sep	15864559
Role of 5-HT3 and 5-HT2C receptors located within the medial amygdala in the control of salt intake in sodium-depleted rats.	2006 Jul 12	16765332
Inhibition of the serotonin-induced inward current by dextromethorphan in rat nodose ganglion neurons.	2006 Jun 30	16730674
The roles of dopamine and serotonin, and of their receptors, in regulating sleep and waking.	2008	18772053
Antidepressants inhibit P2X4 receptor function: a possible involvement in neuropathic pain relief.	2009 Apr 23	19389225
Cross-regulation between colocalized nicotinic acetylcholine and 5-HT3 serotonin receptors on presynaptic nerve terminals.	2009 Jun	19498419
Responses to 5-HT in morphologically identified neurons in the rat substantia gelatinosa in vitro.	2009 Mar 3	19141313
Interactions between the anxiogenic effects of CB1 gene disruption and 5-HT3 neurotransmission.	2009 May	19421027
5-hydroxytryptamine induced relaxation in the pig urinary bladder neck.	2009 May	19309355
Central 5-HT3 receptor-induced hypothermia in mice: interstrain differences and comparison with hypothermia mediated via 5-HT1A receptor.	2009 Nov 6	19735696
Characterization of the contractile 5-hydroxytryptamine receptor in the autoperfused kidney of L-NAME hypertensive rats.	2009 Oct 12	19699736
Facilitatory actions of serotonin type 3 receptors on GABAergic inhibitory synaptic transmission in the spinal superficial dorsal horn.	2009 Sep	19369358
Activation of 5-HT3 receptors leads to altered responses 6 months after MDMA treatment.	2010 Mar	20052506

Substance Class	Chemical Created by `admin` on `Fri Dec 15 19:39:47 GMT 2023` Edited by `admin` on `Fri Dec 15 19:39:47 GMT 2023`
Record UNII	910A4X901V
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

1-(3-CHLOROPHENYL)BIGUANIDE

Systematic Name

English

M-CHLOROPHENYLBIGUANIDE

Systematic Name

English

Code System Code Type Description

WIKIPEDIA

Chlorophenylbiguanide