Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C8H10ClN5.ClH |
| Molecular Weight | 248.112 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.NC(=N)NC(=N)NC1=CC(Cl)=CC=C1
InChI
InChIKey=FOWAIJYHRWFTHR-UHFFFAOYSA-N
InChI=1S/C8H10ClN5.ClH/c9-5-2-1-3-6(4-5)13-8(12)14-7(10)11;/h1-4H,(H6,10,11,12,13,14);1H
| Molecular Formula | C8H10ClN5 |
| Molecular Weight | 211.652 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Pharmacological characterization of a rat 5-hydroxytryptamine type3 receptor subunit (r5-HT3A(b)) expressed in Xenopus laevis oocytes. | 1998 Aug |
|
| Different efficacy of specific agonists at 5-HT3 receptor splice variants: the role of the extra six amino acid segment. | 1998 Feb |
|
| Promiscuous coassembly of serotonin 5-HT3 and nicotinic alpha4 receptor subunits into Ca(2+)-permeable ion channels. | 1998 Sep 15 |
|
| The 5-HT3B subunit is a major determinant of serotonin-receptor function. | 1999 Jan 28 |
|
| The anxiolytic-like effect of MCI-225, a selective NA reuptake inhibitor with 5-HT3 receptor antagonism. | 2001 Apr |
|
| Pharmacological comparison of human homomeric 5-HT3A receptors versus heteromeric 5-HT3A/3B receptors. | 2001 Aug |
|
| Hypoglossal nerve response to 5-HT3 drugs injected into the XII nucleus and vena cava in the rat. | 2001 Dec 15 |
|
| [(3)H]-serotonin release from bovine iris-ciliary body: pharmacology of prejunctional serotonin (5-HT(7)) autoreceptors. | 2001 Jul |
|
| Different effects of 5-HT receptor agonists on operant response in rats under DRL 10-s and DRL 30-s schedules. | 2001 Oct |
|
| Serotonin(3) receptor stimulation in the nucleus tractus solitarii activates non-catecholaminergic neurons in the rat ventrolateral medulla. | 2002 |
|
| The nature of the acetylcholine and 5-hydroxytryptamine receptors in buccal smooth muscle of the pest slug Deroceras reticulatum. | 2002 Apr |
|
| Pharmacology of serotonin receptors modulating electrically-induced [3h]-norepinephrine release from isolated mammalian iris-ciliary bodies. | 2002 Aug |
|
| Endogenous cannabinoid, anandamide, acts as a noncompetitive inhibitor on 5-HT3 receptor-mediated responses in Xenopus oocytes. | 2002 Dec 1 |
|
| 5-HT3 receptors in selective animal models of cognition. | 2002 Feb |
|
| Central 5-HT3 receptor stimulation by m-CPBG increases blood glucose in rats. | 2002 Feb |
|
| Glutamate and NO mediation of the pressor response to 5-HT3 receptor stimulation in the nucleus tractus solitarii. | 2002 May 7 |
|
| Central 5-HT(3) receptors and water intake in rats. | 2002 Nov |
|
| Dopamine and serotonin receptors mediating contractions of the snail, Helix pomatia, salivary duct. | 2003 |
|
| Serotonin induces tonic firing in layer V pyramidal neurons of rat prefrontal cortex during postnatal development. | 2003 Apr 15 |
|
| Central 5-HT2B/2C and 5-HT3 receptor stimulation decreases salt intake in sodium-depleted rats. | 2003 Aug 15 |
|
| Effect of pharmacologically induced smooth muscle activation on permeability in murine colitis. | 2003 Feb |
|
| Introduction of the 5-HT3B subunit alters the functional properties of 5-HT3 receptors native to neuroblastoma cells. | 2003 Feb |
|
| Characterization of the 5-hydroxytryptamine receptors mediating contraction in the pig isolated intravesical ureter. | 2003 Jan |
|
| Action of 5-HT3 receptor antagonists and dexamethasone to modify cisplatin-induced emesis in Suncus murinus (house musk shrew). | 2003 Jul 4 |
|
| Heterogeneous actions of serotonin on interneurons in rat visual cortex. | 2003 Mar |
|
| Conformationally-restricted analogues and partition coefficients of the 5-HT3 serotonin receptor ligands meta-chlorophenylbiguanide (mCPBG) and meta-chlorophenylguanidine (mCPG). | 2003 Mar 24 |
|
| Calcium influx through presynaptic 5-HT3 receptors facilitates GABA release in the hippocampus: in vitro slice and synaptosome studies. | 2004 |
|
| The 5-HT3 receptor facilitates at-level mechanical allodynia following spinal cord injury. | 2004 Jul |
|
| Serotonergic modulation of intracellular calcium dynamics in neonatal hypoglossal motoneurons from mouse. | 2004 Mar 19 |
|
| Role of central 5-HT3 receptors in the control of blood pressure in stressed and non-stressed rats. | 2004 Nov 26 |
|
| Serotonin type 3 receptors modulate the aggression-stimulating effects of adolescent cocaine exposure in Syrian hamsters (Mesocricetus auratus). | 2004 Oct |
|
| Effects of quipazine and m-chlorophenylbiguanide (m-CPBG) on the discrimination of durations: evidence for the involvement of 5-HT2A but not 5-HT3 receptors. | 2005 Feb |
|
| The serotonin type 3A receptor facilitates luteinizing hormone release and LHbeta promoter activity in immortalized pituitary gonadotropes. | 2005 Jun |
|
| Absence of 5-HT3 and cholinergic mechanisms in improgan antinociception. | 2005 Mar |
|
| Involvement of c-Src and protein kinase C delta in the inhibition of Cl(-)/OH- exchange activity in Caco-2 cells by serotonin. | 2005 Mar 25 |
|
| Lack of reciprocity between opioid and 5-HT3 receptors for antinociception in rat spinal cord. | 2006 |
|
| Activity-dependent modulation of axonal excitability in unmyelinated peripheral rat nerve fibers by the 5-HT(3) serotonin receptor. | 2006 Dec |
|
| Role of 5-HT3 and 5-HT2C receptors located within the medial amygdala in the control of salt intake in sodium-depleted rats. | 2006 Jul 12 |
|
| Effects of repeated daily treatments with a 5-HT3 receptor antagonist on dopamine neurotransmission and functional activity of 5-HT3 receptors within the nucleus accumbens of Wistar rats. | 2006 Jun |
|
| Inhibition of the serotonin-induced inward current by dextromethorphan in rat nodose ganglion neurons. | 2006 Jun 30 |
|
| Molecular cloning and pharmacological characterization of serotonin 5-HT(3A) receptor subtype in dog. | 2006 May 24 |
|
| The reinforcing actions of a serotonin-3 receptor agonist within the ventral tegmental area: evidence for subregional and genetic differences and involvement of dopamine neurons. | 2007 Jun |
|
| 5-hydroxytryptamine induced relaxation in the pig urinary bladder neck. | 2009 May |
|
| Activation of serotonin 3 receptors changes in vivo auditory responses in the mouse inferior colliculus. | 2009 May |
|
| Central 5-HT3 receptor-induced hypothermia in mice: interstrain differences and comparison with hypothermia mediated via 5-HT1A receptor. | 2009 Nov 6 |
|
| Facilitatory actions of serotonin type 3 receptors on GABAergic inhibitory synaptic transmission in the spinal superficial dorsal horn. | 2009 Sep |
|
| Granisetron ameliorates acetic acid-induced colitis in rats. | 2010 Apr |
|
| The nucleus raphe magnus suppresses vomiting, and the solitary nucleus and 5-HT are not involved in this suppression. | 2010 Jan 15 |
|
| 5-HT3 receptor-dependent modulation of respiratory burst frequency, regularity, and episodicity in isolated adult turtle brainstems. | 2010 Jun 30 |
|
| Activation of 5-HT3 receptors leads to altered responses 6 months after MDMA treatment. | 2010 Mar |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 12:52:50 GMT 2023
by
admin
on
Sat Dec 16 12:52:50 GMT 2023
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| Record UNII |
KUM9PU5NEY
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| Record Status |
Validated (UNII)
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| Record Version |
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210906
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DTXSID80175361
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2730228
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KUM9PU5NEY
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2113-05-5
Created by
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