Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C8H10ClN5.ClH |
| Molecular Weight | 248.112 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.NC(=N)NC(=N)NC1=CC=CC(Cl)=C1
InChI
InChIKey=FOWAIJYHRWFTHR-UHFFFAOYSA-N
InChI=1S/C8H10ClN5.ClH/c9-5-2-1-3-6(4-5)13-8(12)14-7(10)11;/h1-4H,(H6,10,11,12,13,14);1H
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C8H10ClN5 |
| Molecular Weight | 211.652 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| 5-HT3 receptor-dependent modulation of respiratory burst frequency, regularity, and episodicity in isolated adult turtle brainstems. | 2010-06-30 |
|
| Granisetron ameliorates acetic acid-induced colitis in rats. | 2010-04 |
|
| Activation of 5-HT3 receptors leads to altered responses 6 months after MDMA treatment. | 2010-03 |
|
| The nucleus raphe magnus suppresses vomiting, and the solitary nucleus and 5-HT are not involved in this suppression. | 2010-01-15 |
|
| Central 5-HT3 receptor-induced hypothermia in mice: interstrain differences and comparison with hypothermia mediated via 5-HT1A receptor. | 2009-11-06 |
|
| Characterization of the contractile 5-hydroxytryptamine receptor in the autoperfused kidney of L-NAME hypertensive rats. | 2009-10-12 |
|
| Facilitatory actions of serotonin type 3 receptors on GABAergic inhibitory synaptic transmission in the spinal superficial dorsal horn. | 2009-09 |
|
| Antidepressant-like effect of the extract of Rosmarinus officinalis in mice: involvement of the monoaminergic system. | 2009-06-15 |
|
| Cross-regulation between colocalized nicotinic acetylcholine and 5-HT3 serotonin receptors on presynaptic nerve terminals. | 2009-06 |
|
| Interactions between the anxiogenic effects of CB1 gene disruption and 5-HT3 neurotransmission. | 2009-05 |
|
| 5-hydroxytryptamine induced relaxation in the pig urinary bladder neck. | 2009-05 |
|
| Activation of serotonin 3 receptors changes in vivo auditory responses in the mouse inferior colliculus. | 2009-05 |
|
| Antidepressants inhibit P2X4 receptor function: a possible involvement in neuropathic pain relief. | 2009-04-23 |
|
| Responses to 5-HT in morphologically identified neurons in the rat substantia gelatinosa in vitro. | 2009-03-03 |
|
| Activation of the serotonin 5-HT3 receptor in the dorsal raphe nucleus suppresses REM sleep in the rat. | 2008-05-15 |
|
| The roles of dopamine and serotonin, and of their receptors, in regulating sleep and waking. | 2008 |
|
| Demonstration of 5-HT(3) receptor function and expression in the mouse bladder. | 2007-08 |
|
| Roles of 5-hydroxytryptamine (5-HT) receptor subtypes in the inhibitory effects of 5-HT on C-fiber responses of spinal wide dynamic range neurons in rats. | 2007-06 |
|
| The reinforcing actions of a serotonin-3 receptor agonist within the ventral tegmental area: evidence for subregional and genetic differences and involvement of dopamine neurons. | 2007-06 |
|
| Activity-dependent modulation of axonal excitability in unmyelinated peripheral rat nerve fibers by the 5-HT(3) serotonin receptor. | 2006-12 |
|
| Activation of serotonin-3 receptors increases dopamine release within the ventral tegmental area of Wistar and alcohol-preferring (P) rats. | 2006-11 |
|
| Role of 5-HT3 and 5-HT2C receptors located within the medial amygdala in the control of salt intake in sodium-depleted rats. | 2006-07-12 |
|
| Inhibition of the serotonin-induced inward current by dextromethorphan in rat nodose ganglion neurons. | 2006-06-30 |
|
| Effects of repeated daily treatments with a 5-HT3 receptor antagonist on dopamine neurotransmission and functional activity of 5-HT3 receptors within the nucleus accumbens of Wistar rats. | 2006-06 |
|
| Molecular cloning and pharmacological characterization of serotonin 5-HT(3A) receptor subtype in dog. | 2006-05-24 |
|
| Lack of reciprocity between opioid and 5-HT3 receptors for antinociception in rat spinal cord. | 2006 |
|
| Effects of quipazine and m-chlorophenylbiguanide (m-CPBG) on temporal differentiation: evidence for the involvement of 5-HT2A but not 5-HT3 receptors in interval timing behaviour. | 2005-09 |
|
| The loop C region of the murine 5-HT3A receptor contributes to the differential actions of 5-hydroxytryptamine and m-chlorophenylbiguanide. | 2005-06-28 |
|
| The serotonin type 3A receptor facilitates luteinizing hormone release and LHbeta promoter activity in immortalized pituitary gonadotropes. | 2005-06 |
|
| Involvement of c-Src and protein kinase C delta in the inhibition of Cl(-)/OH- exchange activity in Caco-2 cells by serotonin. | 2005-03-25 |
|
| Absence of 5-HT3 and cholinergic mechanisms in improgan antinociception. | 2005-03 |
|
| Involvement of spinal serotonin receptors in the regulation of intraspinal acetylcholine release. | 2005-02-21 |
|
| Effects of quipazine and m-chlorophenylbiguanide (m-CPBG) on the discrimination of durations: evidence for the involvement of 5-HT2A but not 5-HT3 receptors. | 2005-02 |
|
| Serotonin type 3 receptors stimulate offensive aggression in Syrian hamsters. | 2005-01-06 |
|
| Chemical mediators enhance the excitability of unmyelinated sensory axons in normal and injured peripheral nerve of the rat. | 2005 |
|
| Role of central 5-HT3 receptors in the control of blood pressure in stressed and non-stressed rats. | 2004-11-26 |
|
| Subunit rotation models activation of serotonin 5-HT3AB receptors by agonists. | 2004-10 |
|
| Serotonin type 3 receptors modulate the aggression-stimulating effects of adolescent cocaine exposure in Syrian hamsters (Mesocricetus auratus). | 2004-10 |
|
| Acetaminophen: a central analgesic drug that involves a spinal tropisetron-sensitive, non-5-HT(3) receptor-mediated effect. | 2004-09 |
|
| The 5-HT3 receptor facilitates at-level mechanical allodynia following spinal cord injury. | 2004-07 |
|
| Allosteric modulation of glycine receptors is more efficacious for partial rather than full agonists. | 2004-06 |
|
| Calcium influx through presynaptic 5-HT3 receptors facilitates GABA release in the hippocampus: in vitro slice and synaptosome studies. | 2004 |
|
| The 5-HT3B subunit is a major determinant of serotonin-receptor function. | 1999-01-28 |
|
| Promiscuous coassembly of serotonin 5-HT3 and nicotinic alpha4 receptor subunits into Ca(2+)-permeable ion channels. | 1998-09-15 |
|
| Pharmacological characterization of a rat 5-hydroxytryptamine type3 receptor subunit (r5-HT3A(b)) expressed in Xenopus laevis oocytes. | 1998-08 |
|
| Different efficacy of specific agonists at 5-HT3 receptor splice variants: the role of the extra six amino acid segment. | 1998-02 |
|
| Molecular cloning, functional expression, and pharmacological characterization of 5-hydroxytryptamine3 receptor cDNA and its splice variants from guinea pig. | 1998-02 |
|
| Characterization of a human 5-hydroxytryptamine3 receptor type A (h5-HT3R-AS) subunit stably expressed in HEK 293 cells. | 1996-07 |
|
| Cloning and functional expression of a human 5-hydroxytryptamine type 3AS receptor subunit. | 1995-12 |
|
| Molecular cloning of human 5-hydroxytryptamine3 receptor: heterogeneity in distribution and function among species. | 1995-09 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Tue Apr 01 19:55:40 GMT 2025
by
admin
on
Tue Apr 01 19:55:40 GMT 2025
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| Record UNII |
KUM9PU5NEY
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| Record Status |
Validated (UNII)
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| Record Version |
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210906
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DTXSID80175361
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2730228
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KUM9PU5NEY
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2113-05-5
Created by
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