Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C8H10ClN5.ClH |
| Molecular Weight | 248.112 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.NC(=N)NC(=N)NC1=CC(Cl)=CC=C1
InChI
InChIKey=FOWAIJYHRWFTHR-UHFFFAOYSA-N
InChI=1S/C8H10ClN5.ClH/c9-5-2-1-3-6(4-5)13-8(12)14-7(10)11;/h1-4H,(H6,10,11,12,13,14);1H
| Molecular Formula | C8H10ClN5 |
| Molecular Weight | 211.652 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Promiscuous coassembly of serotonin 5-HT3 and nicotinic alpha4 receptor subunits into Ca(2+)-permeable ion channels. | 1998 Sep 15 |
|
| Pharmacological comparison of human homomeric 5-HT3A receptors versus heteromeric 5-HT3A/3B receptors. | 2001 Aug |
|
| Serotonin increases the incidence of primary afferent-evoked long-term depression in rat deep dorsal horn neurons. | 2001 May |
|
| Characterization of discriminative stimulus effects of the neuroactive steroid pregnanolone. | 2001 May |
|
| Serotonin(3) receptor stimulation in the nucleus tractus solitarii activates non-catecholaminergic neurons in the rat ventrolateral medulla. | 2002 |
|
| The nature of the acetylcholine and 5-hydroxytryptamine receptors in buccal smooth muscle of the pest slug Deroceras reticulatum. | 2002 Apr |
|
| Pharmacology of serotonin receptors modulating electrically-induced [3h]-norepinephrine release from isolated mammalian iris-ciliary bodies. | 2002 Aug |
|
| Central 5-HT3 receptor stimulation by m-CPBG increases blood glucose in rats. | 2002 Feb |
|
| Glutamate and NO mediation of the pressor response to 5-HT3 receptor stimulation in the nucleus tractus solitarii. | 2002 May 7 |
|
| Action of 5-HT3 receptor antagonists and dexamethasone to modify cisplatin-induced emesis in Suncus murinus (house musk shrew). | 2003 Jul 4 |
|
| Conformationally-restricted analogues and partition coefficients of the 5-HT3 serotonin receptor ligands meta-chlorophenylbiguanide (mCPBG) and meta-chlorophenylguanidine (mCPG). | 2003 Mar 24 |
|
| Calcium influx through presynaptic 5-HT3 receptors facilitates GABA release in the hippocampus: in vitro slice and synaptosome studies. | 2004 |
|
| Role of central 5-HT3 receptors in the control of blood pressure in stressed and non-stressed rats. | 2004 Nov 26 |
|
| Serotonin type 3 receptors modulate the aggression-stimulating effects of adolescent cocaine exposure in Syrian hamsters (Mesocricetus auratus). | 2004 Oct |
|
| Chemical mediators enhance the excitability of unmyelinated sensory axons in normal and injured peripheral nerve of the rat. | 2005 |
|
| Serotonin type 3 receptors stimulate offensive aggression in Syrian hamsters. | 2005 Jan 6 |
|
| Absence of 5-HT3 and cholinergic mechanisms in improgan antinociception. | 2005 Mar |
|
| Effects of repeated daily treatments with a 5-HT3 receptor antagonist on dopamine neurotransmission and functional activity of 5-HT3 receptors within the nucleus accumbens of Wistar rats. | 2006 Jun |
|
| Demonstration of 5-HT(3) receptor function and expression in the mouse bladder. | 2007 Aug |
|
| Roles of 5-hydroxytryptamine (5-HT) receptor subtypes in the inhibitory effects of 5-HT on C-fiber responses of spinal wide dynamic range neurons in rats. | 2007 Jun |
|
| The roles of dopamine and serotonin, and of their receptors, in regulating sleep and waking. | 2008 |
|
| Activation of the serotonin 5-HT3 receptor in the dorsal raphe nucleus suppresses REM sleep in the rat. | 2008 May 15 |
|
| Antidepressants inhibit P2X4 receptor function: a possible involvement in neuropathic pain relief. | 2009 Apr 23 |
|
| Antidepressant-like effect of the extract of Rosmarinus officinalis in mice: involvement of the monoaminergic system. | 2009 Jun 15 |
|
| Responses to 5-HT in morphologically identified neurons in the rat substantia gelatinosa in vitro. | 2009 Mar 3 |
|
| 5-hydroxytryptamine induced relaxation in the pig urinary bladder neck. | 2009 May |
|
| Characterization of the contractile 5-hydroxytryptamine receptor in the autoperfused kidney of L-NAME hypertensive rats. | 2009 Oct 12 |
|
| Facilitatory actions of serotonin type 3 receptors on GABAergic inhibitory synaptic transmission in the spinal superficial dorsal horn. | 2009 Sep |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 12:52:50 GMT 2023
by
admin
on
Sat Dec 16 12:52:50 GMT 2023
|
| Record UNII |
KUM9PU5NEY
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Systematic Name | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
210906
Created by
admin on Sat Dec 16 12:52:51 GMT 2023 , Edited by admin on Sat Dec 16 12:52:51 GMT 2023
|
PRIMARY | |||
|
DTXSID80175361
Created by
admin on Sat Dec 16 12:52:51 GMT 2023 , Edited by admin on Sat Dec 16 12:52:51 GMT 2023
|
PRIMARY | |||
|
2730228
Created by
admin on Sat Dec 16 12:52:51 GMT 2023 , Edited by admin on Sat Dec 16 12:52:51 GMT 2023
|
PRIMARY | |||
|
KUM9PU5NEY
Created by
admin on Sat Dec 16 12:52:51 GMT 2023 , Edited by admin on Sat Dec 16 12:52:51 GMT 2023
|
PRIMARY | |||
|
2113-05-5
Created by
admin on Sat Dec 16 12:52:51 GMT 2023 , Edited by admin on Sat Dec 16 12:52:51 GMT 2023
|
PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
PARENT -> SALT/SOLVATE |
|
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
ACTIVE MOIETY |
|