TRIPTORELIN

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Description
Sources: http://www.drugbank.ca/drugs/DB06825
Curator's Comment: Description was created based on several sources, including http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020715s024,021288s021,022437s002lbl.pdf

Triptorelin is a synthetic decapeptide agonist analog of luteinizing hormone releasing hormone (LHRH). It works by decreasing the production of certain hormones, which reduces testosterone levels in the body. Animal studies comparing triptorelin to native GnRH found that triptorelin had 13 fold higher releasing activity for luteinizing hormone, and 21-fold higher releasing activity for follicle-stimulating hormone. Triptorelin is indicated for the palliative treatment of advanced prostate cancer.

Originator

Approval Year

Targets

Targets

Primary Target	Pharmacology	Condition	Potency
Gonadotropin-releasing hormone receptor 41 Target ID: CHEMBL1855 Sources: http://www.drugbank.ca/drugs/DB06825	Agonist 2678		0.3 nM [Ki]

Conditions

Conditions

Condition	Modality	Targets	Highest Phase	Product
Advanced prostate cancer 9 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020715s024,021288s021,022437s002lbl.pdf	Palliative		Approved 8429	TRELSTAR Approved Use Indicated for the palliative treatment of advanced prostate cancer. Launch Date 9.609408E11

PubMed

PubMed

Title	Date	PubMed

Patents

Patents

Sample Use Guides

In Vivo Use Guide

Administered as a single intramuscular injection in either buttock. Due to different release characteristics, the dosage strengths are not additive and must be selected based upon the desired dosing schedule. • 3.75 mg every 4 weeks. • 11.25 mg every 12 weeks • 22.5 mg every 24 weeks

Route of Administration: Intramuscular

In Vitro Use Guide

Triptorelin stimulates both oxytocin (OT) and vasopressin (AVP) release from the rat hypothalamo-neurohypophysial (H-N) system at concentrations of 10(-9)-10(-5) M. The strongest effect was displayed by triptorelin at a concentration of 10(-7) M.

Substance Class	Protein Created by `admin` on `Sat Dec 16 00:36:38 UTC 2023` Edited by `admin` on `Sat Dec 16 00:36:38 UTC 2023`
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	9081Y98W2V
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TRIPTORELIN

Official Name

English

TRIPTORELIN [MI]

Common Name

English

CL 118,532

Code

English

TRIPTORELIN [MART.]

Common Name

English

5-OXO-L-PROLYL-L-HISTIDYL-L-TRYPTOPHYL-L-SERYL-L-TYROSYL-D-TRYPTOPHYL-L-LEUCYL-L-ARGINYL-L-PROLYLGLYCINAMIDE

Common Name

English

TRIPTORELIN [USAN]

Common Name

English

TRIPTODUR

Brand Name

English

WY-42462

Code

English

CL-118532

Code

English

triptorelin [INN]

Common Name

English

ARVEKAP

Brand Name

English

AY-25650

Code

English

TRIPTORELIN [VANDF]

Common Name

English

TRYPTORELIN

Common Name

English

Triptorelin [WHO-DD]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C1910

Created by admin on Sat Dec 16 00:36:38 UTC 2023 , Edited by admin on Sat Dec 16 00:36:38 UTC 2023

NDF-RT

N0000175655

Created by admin on Sat Dec 16 00:36:38 UTC 2023 , Edited by admin on Sat Dec 16 00:36:38 UTC 2023

LIVERTOX

NBK548756

Created by admin on Sat Dec 16 00:36:38 UTC 2023 , Edited by admin on Sat Dec 16 00:36:38 UTC 2023

NCI_THESAURUS

C242

Created by admin on Sat Dec 16 00:36:38 UTC 2023 , Edited by admin on Sat Dec 16 00:36:38 UTC 2023

WHO-VATC

QL02AE04

Created by admin on Sat Dec 16 00:36:38 UTC 2023 , Edited by admin on Sat Dec 16 00:36:38 UTC 2023

NDF-RT

N0000175654

Created by admin on Sat Dec 16 00:36:38 UTC 2023 , Edited by admin on Sat Dec 16 00:36:38 UTC 2023

WHO-ATC

L02AE04

Created by admin on Sat Dec 16 00:36:38 UTC 2023 , Edited by admin on Sat Dec 16 00:36:38 UTC 2023

Code System Code Type Description

DRUG BANK

DB06825

Created by admin on Sat Dec 16 00:36:38 UTC 2023 , Edited by admin on Sat Dec 16 00:36:38 UTC 2023

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PUBCHEM

25074470

Created by admin on Sat Dec 16 00:36:38 UTC 2023 , Edited by admin on Sat Dec 16 00:36:38 UTC 2023

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CAS

57773-63-4

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MERCK INDEX

m11194

Created by admin on Sat Dec 16 00:36:38 UTC 2023 , Edited by admin on Sat Dec 16 00:36:38 UTC 2023

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Merck Index

CHEBI

63633

Created by admin on Sat Dec 16 00:36:38 UTC 2023 , Edited by admin on Sat Dec 16 00:36:38 UTC 2023

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WIKIPEDIA

TRIPTORELIN

Created by admin on Sat Dec 16 00:36:38 UTC 2023 , Edited by admin on Sat Dec 16 00:36:38 UTC 2023

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EPA CompTox

DTXSID2048375

Created by admin on Sat Dec 16 00:36:38 UTC 2023 , Edited by admin on Sat Dec 16 00:36:38 UTC 2023

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SMS_ID

100000092206

Created by admin on Sat Dec 16 00:36:38 UTC 2023 , Edited by admin on Sat Dec 16 00:36:38 UTC 2023

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ChEMBL

CHEMBL1201334

Created by admin on Sat Dec 16 00:36:38 UTC 2023 , Edited by admin on Sat Dec 16 00:36:38 UTC 2023

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EVMPD

SUB11324MIG

Created by admin on Sat Dec 16 00:36:38 UTC 2023 , Edited by admin on Sat Dec 16 00:36:38 UTC 2023

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INN

5711

Created by admin on Sat Dec 16 00:36:38 UTC 2023 , Edited by admin on Sat Dec 16 00:36:38 UTC 2023

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DRUG CENTRAL

2968

Created by admin on Sat Dec 16 00:36:38 UTC 2023 , Edited by admin on Sat Dec 16 00:36:38 UTC 2023

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DAILYMED

9081Y98W2V

Created by admin on Sat Dec 16 00:36:38 UTC 2023 , Edited by admin on Sat Dec 16 00:36:38 UTC 2023

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USAN

W-59

Created by admin on Sat Dec 16 00:36:38 UTC 2023 , Edited by admin on Sat Dec 16 00:36:38 UTC 2023

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NCI_THESAURUS

C1267

Created by admin on Sat Dec 16 00:36:38 UTC 2023 , Edited by admin on Sat Dec 16 00:36:38 UTC 2023

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FDA UNII

9081Y98W2V

Created by admin on Sat Dec 16 00:36:38 UTC 2023 , Edited by admin on Sat Dec 16 00:36:38 UTC 2023

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RXCUI

38782

Created by admin on Sat Dec 16 00:36:38 UTC 2023 , Edited by admin on Sat Dec 16 00:36:38 UTC 2023

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RxNorm

IUPHAR

1177

Created by admin on Sat Dec 16 00:36:38 UTC 2023 , Edited by admin on Sat Dec 16 00:36:38 UTC 2023

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Related Record Type Details


					43OFW291R9

TRIPTORELIN ACETATE

SALT/SOLVATE -> PARENT


					MJK4KMT12V

GONADOTROPIN-RELEASING HORMONE RECEPTOR

TARGET -> AGONIST


					08AN7WA2G0

TRIPTORELIN PAMOATE

INGREDIENT -> STARTING MATERIAL


					08AN7WA2G0

TRIPTORELIN PAMOATE

SALT/SOLVATE -> PARENT


					43OFW291R9

TRIPTORELIN ACETATE

INGREDIENT -> STARTING MATERIAL

Amount:

Related Record Type Details


					9081Y98W2V

ACTIVE MOIETY

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL