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Description
Curator's Comment:: Description was created based on several sources, including http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020715s024,021288s021,022437s002lbl.pdf

Triptorelin is a synthetic decapeptide agonist analog of luteinizing hormone releasing hormone (LHRH). It works by decreasing the production of certain hormones, which reduces testosterone levels in the body. Animal studies comparing triptorelin to native GnRH found that triptorelin had 13 fold higher releasing activity for luteinizing hormone, and 21-fold higher releasing activity for follicle-stimulating hormone. Triptorelin is indicated for the palliative treatment of advanced prostate cancer.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
0.3 nM [Ki]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
TRELSTAR

Approved Use

Indicated for the palliative treatment of advanced prostate cancer.

Launch Date

9.609408E11
PubMed

PubMed

TitleDatePubMed
Patents

Sample Use Guides

Administered as a single intramuscular injection in either buttock. Due to different release characteristics, the dosage strengths are not additive and must be selected based upon the desired dosing schedule. • 3.75 mg every 4 weeks. • 11.25 mg every 12 weeks • 22.5 mg every 24 weeks
Route of Administration: Intramuscular
Triptorelin stimulates both oxytocin (OT) and vasopressin (AVP) release from the rat hypothalamo-neurohypophysial (H-N) system at concentrations of 10(-9)-10(-5) M. The strongest effect was displayed by triptorelin at a concentration of 10(-7) M.
Substance Class Protein
Created
by admin
on Sat Jun 26 11:43:45 UTC 2021
Edited
by admin
on Sat Jun 26 11:43:45 UTC 2021
Protein Sub Type
Record UNII
43OFW291R9
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
TRIPTORELIN ACETATE
MART.   MI   WHO-DD  
Common Name English
TRIPTORELIN ACETATE [GREEN BOOK]
Common Name English
TRIPTORELIN ACETATE [USP-RS]
Common Name English
TRIPTORELIN ACETATE [MART.]
Common Name English
TRIPTORELIN ACETATE [MI]
Common Name English
TRIPTORELIN ACETATE [WHO-DD]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C1910
Created by admin on Sat Jun 26 11:43:45 UTC 2021 , Edited by admin on Sat Jun 26 11:43:45 UTC 2021
Code System Code Type Description
MERCK INDEX
M11194
Created by admin on Sat Jun 26 11:43:45 UTC 2021 , Edited by admin on Sat Jun 26 11:43:45 UTC 2021
PRIMARY Merck Index
RXCUI
236538
Created by admin on Sat Jun 26 11:43:45 UTC 2021 , Edited by admin on Sat Jun 26 11:43:45 UTC 2021
PRIMARY RxNorm
FDA UNII
43OFW291R9
Created by admin on Sat Jun 26 11:43:45 UTC 2021 , Edited by admin on Sat Jun 26 11:43:45 UTC 2021
PRIMARY
EVMPD
SUB04985MIG
Created by admin on Sat Jun 26 11:43:45 UTC 2021 , Edited by admin on Sat Jun 26 11:43:45 UTC 2021
PRIMARY
PUBCHEM
25080282
Created by admin on Sat Jun 26 11:43:45 UTC 2021 , Edited by admin on Sat Jun 26 11:43:45 UTC 2021
PRIMARY
USP_CATALOG
1696131
Created by admin on Sat Jun 26 11:43:45 UTC 2021 , Edited by admin on Sat Jun 26 11:43:45 UTC 2021
PRIMARY USP-RS
NCI_THESAURUS
C128693
Created by admin on Sat Jun 26 11:43:45 UTC 2021 , Edited by admin on Sat Jun 26 11:43:45 UTC 2021
PRIMARY
CAS
140194-24-7
Created by admin on Sat Jun 26 11:43:45 UTC 2021 , Edited by admin on Sat Jun 26 11:43:45 UTC 2021
PRIMARY
DRUG BANK
DBSALT001171
Created by admin on Sat Jun 26 11:43:45 UTC 2021 , Edited by admin on Sat Jun 26 11:43:45 UTC 2021
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
STARTING MATERIAL -> INGREDIENT
Related Record Type Details
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT:SEQUENCE(CALCULATED) CHEMICAL