FEMOXETINE

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C20H25NO2
Molecular Weight	311.418
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

COC1=CC=C(OC[C@H]2CN(C)CC[C@@H]2C3=CC=CC=C3)C=C1

InChI

InChIKey=OJSFTALXCYKKFQ-YLJYHZDGSA-N

InChI=1S/C20H25NO2/c1-21-13-12-20(16-6-4-3-5-7-16)17(14-21)15-23-19-10-8-18(22-2)9-11-19/h3-11,17,20H,12-15H2,1-2H3/t17-,20-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C20H25NO2
Molecular Weight	311.418
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description

Femoxetine is a selective serotonin re-uptake inhibitor. It was being studied in the treatment of narcolepsy, migraine, depressive states and eating disorder. Femoxetine development has been discontinued.

CNS Activity

Originator

Approval Year

PubMed

Show entries

Title	Date	PubMed
Inhibition of HIV replication by neuroleptic agents and their potential use in HIV infected patients with AIDS related dementia.	2000 Apr	10773489
Structural differences between paroxetine and femoxetine responsible for differential inhibition of Staphylococcus aureus efflux pumps.	2004 Jun 21	15149651
Antidepressant drugs for narcolepsy.	2005 Jul 20	16034909
Reversal of resistance in microorganisms by help of non-antibiotics.	2007 Jun	17403708
Antidepressant drugs for narcolepsy.	2008 Jan 23	18254030