FEMOXETINE HYDROCHLORIDE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C20H25NO2.ClH
Molecular Weight	347.879
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.COC1=CC=C(OC[C@H]2CN(C)CC[C@@H]2C3=CC=CC=C3)C=C1

InChI

InChIKey=ORJNLCKHRRUOMU-OGPPPPIKSA-N

InChI=1S/C20H25NO2.ClH/c1-21-13-12-20(16-6-4-3-5-7-16)17(14-21)15-23-19-10-8-18(22-2)9-11-19;/h3-11,17,20H,12-15H2,1-2H3;1H/t17-,20-;/m1./s1

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C20H25NO2
Molecular Weight	311.418
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/8445992 | https://adisinsight.springer.com/drugs/800000721 | https://www.ncbi.nlm.nih.gov/pubmed/3544654 | https://www.ncbi.nlm.nih.gov/pubmed/6753446 | https://www.ncbi.nlm.nih.gov/pubmed/3067246 | https://www.ncbi.nlm.nih.gov/pubmed/3301710

Femoxetine is a selective serotonin re-uptake inhibitor. It was being studied in the treatment of narcolepsy, migraine, depressive states and eating disorder. Femoxetine development has been discontinued.

CNS Activity

Originator

Approval Year

PubMed

Title	Date	PubMed
Phenylpiperidine selective serotonin reuptake inhibitors interfere with multidrug efflux pump activity in Staphylococcus aureus.	2003 Sep	13678830
Structural differences between paroxetine and femoxetine responsible for differential inhibition of Staphylococcus aureus efflux pumps.	2004 Jun 21	15149651
Reversal of resistance in microorganisms by help of non-antibiotics.	2007 Jun	17403708
Optimizing prophylactic treatment of migraine: Subtypes and patient matching.	2008 Oct	19209286
Aripiprazole Improves Depressive Symptoms and Immunological Response to Antiretroviral Therapy in an HIV-Infected Subject with Resistant Depression.	2010	20369069
Chronic thromboembolic pulmonary hypertension.	2010 Apr	20376164

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:39:45 UTC 2023` Edited by `admin` on `Fri Dec 15 15:39:45 UTC 2023`
Record UNII	2P1X5BE0XG
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

FEMOXETINE HYDROCHLORIDE

Common Name

English

PIPERIDINE, 3-((4-METHOXYPHENOXY)METHYL)-1-METHYL-4-PHENYL-, HYDROCHLORIDE (1:1), (3R,4S)-

Systematic Name

English

FEMOXETINE HCL

Common Name

English

(3R,4S)-3-((4-METHOXYPHENOXY)METHYL)-1-METHYL-4-PHENYLPIPERIDINE HYDROCHLORIDE

Systematic Name

English

Femoxetine hydrochloride [WHO-DD]

Common Name

English

FG-4963

Code

English

FEMOXETINE HYDROCHLORIDE [MI]

Common Name

English

MALEXIL

Brand Name

English

NSC-297940

Code

English

Code System Code Type Description

CAS

56222-04-9