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Details

Stereochemistry RACEMIC
Molecular Formula C4H5N4O3.Al.2HO
Molecular Weight 218.1037
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ALDIOXA

SMILES

[OH-].[OH-].[Al+3].NC(=O)NC1NC(=O)[N-]C1=O

InChI

InChIKey=NZILXMYBYNIXPF-UHFFFAOYSA-K
InChI=1S/C4H6N4O3.Al.2H2O/c5-3(10)6-1-2(9)8-4(11)7-1;;;/h1H,(H5,5,6,7,8,9,10,11);;2*1H2/q;+3;;/p-3

HIDE SMILES / InChI

Molecular Formula C4H6N4O3
Molecular Weight 158.1154
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Molecular Formula HO
Molecular Weight 17.0073
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula Al
Molecular Weight 26.9815386
Charge 3
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

The aluminum salt of Allantoin, Alcloxa combines the astringent and anti-microbial properties of aluminum with the anti-irritant, soothing and healing properties of Allantoin. Alcloxa is particularly suited for use in anti-perspirants, acne treatments and foot care products. Alcloxa is a compound that combine the properties of aluminum salts with the properties of allantion. The allantion component ehhances the action of the aluminum salts and serves to overcome irritations experienced by many individuals who may be sensitive to the use of aluminum alts. The aluminum component reduces sweat by causing the sweat gland ducts swell. Alcloxa also add to the antiperspirant properties the deodorant effect because of its bacteriostatic action. It showed bacteriostatic properties at concentrations of 0.2% particularly against Gram bectaria (B. subtilis, S. aureus, P. vulgaris, Pityrosporum ovale). This is ascribable to two different mechanisms: first bacterial growth is retarded due to a decrease in the amount of water present, second aluminum salt have itself an antimicrobial action. In baby products is indicated for its healing reparative action, in the treatment of diaper rash. Also is approved in haemorrhoidal product for its soothing and keratolytic action. In oral care products Alcloxa is useful for its astringent antibacterial properties. It is very indicated in formulations for sensitive teeth, periodontal and gum diseases (like gingivitis, irritable and bleeding gums). Use levels: 0.1-1%. − In antiacne products the slightly astringent effect promotes healing of pustules and acne lesions. It reduces the extension of infected skin eruptions, healing them and developing a soothing action. May be used alone or also in combinations with other antimicrobial agents in order to fight acne more effectively. Use levels: 0.5-2.0%.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
BODYGLIDE FOR HER

Approved Use

helps prevent and helps relieve chafed, chapped or cracked skin. helps protect from the drying effects of wind and cold weather. temporarily protects minor cuts, scrapes, burns.

Launch Date

2009
Primary
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

protects gastric / duodenal tissue mucosa and helps repair, thus improving gastric / duodenal ulcer and gastritis. It is usually used to improve subjective symptoms or objective of gastric/duodenal ulcer and gastritis.
Primary
Unknown

Approved Use

protects gastric / duodenal tissue mucosa and helps repair, thus improving gastric / duodenal ulcer and gastritis. It is usually used to improve subjective symptoms or objective of gastric/duodenal ulcer and gastritis.
Primary
Unknown

Approved Use

protects gastric / duodenal tissue mucosa and helps repair, thus improving gastric / duodenal ulcer and gastritis. It is usually used to improve subjective symptoms or objective of gastric/duodenal ulcer and gastritis.
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
6.43 μg/mL
10 mg/kg 3 times / day steady-state, oral
dose: 10 mg/kg
route of administration: Oral
experiment type: STEADY-STATE
co-administered:
ALLANTOIN plasma
Canis lupus
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
30 μg × h/mL
10 mg/kg 3 times / day steady-state, oral
dose: 10 mg/kg
route of administration: Oral
experiment type: STEADY-STATE
co-administered:
ALLANTOIN plasma
Canis lupus
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
2.69 h
10 mg/kg 3 times / day steady-state, oral
dose: 10 mg/kg
route of administration: Oral
experiment type: STEADY-STATE
co-administered:
ALLANTOIN plasma
Canis lupus
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
PubMed

PubMed

TitleDatePubMed
Aldioxa improves delayed gastric emptying and impaired gastric compliance, pathophysiologic mechanisms of functional dyspepsia.
2015-12-01
[Acidified aspirin-induced gastric lesion in rats with hepatic cirrhosis produced by N-nitrosodiethylamine or carbon tetrachloride. Effect of aldioxa on gastric lesions].
1994-03
[The effect of aldioxa on the formation of gastritis induced with sodium hydroxide].
1990-11
[Evaluation of the anti-ulcer drugs using image analysis technology: effect of aldioxa containing preparation on the experimental gastric ulcer in rats].
1989-11
[Pharmacological study of dihydroxyaluminum allantoinate and chlorhydroxyaluminum allantoinate. I. Toxicity].
1962-07-01

Sample Use Guides

In general, for adults, take 3 to 4 tablets (300 to 400 mg of the active ingredient) a day, in 3 to 4 divided doses.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Mon Mar 31 19:21:10 GMT 2025
Edited
by admin
on Mon Mar 31 19:21:10 GMT 2025
Record UNII
8T66I31YNK
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ASCOMP
Preferred Name English
ALDIOXA
INCI   INN   MART.   MI   USAN   WHO-DD  
INCI   INN   USAN  
Official Name English
RC 172
Code English
ALDIOXA [MART.]
Common Name English
ALDIOXA [JAN]
Common Name English
ALDIOXA [USAN]
Common Name English
ALDIOXA [MI]
Common Name English
ALUMINUM, DIHYDROXY((4,5-DIHYDRO-2-HYDROXY-5-OXO-1H-IMIDAZOL-4-YL)UREATO)-
Common Name English
aldioxa [INN]
Common Name English
ALUMINIUM DIHYDROXY ALLANTOINATE
Common Name English
ALUMINIUM, DIHYDROXY((4,5-DIHYDRO-2-HYDROXY-5-OXO-1H-IMIDAZOL-4-YL)UREATO)-
Common Name English
ALDA
Code English
RC-172
Code English
ISALON
Brand Name English
ALUMINUM DIHYDROXY ALLANTOINATE
Common Name English
Dihydroxy[2-hydroxy-5-oxo-2-imidazolin-4-yl)ureato]aluminum
Common Name English
Aldioxa [WHO-DD]
Common Name English
DIHYDROXY(2-HYDROXY-5-OXO-2-IMIDAZOLIN-4-YL)UREATO)ALUMINIUM
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C29700
Created by admin on Mon Mar 31 19:21:10 GMT 2025 , Edited by admin on Mon Mar 31 19:21:10 GMT 2025
Code System Code Type Description
DAILYMED
8T66I31YNK
Created by admin on Mon Mar 31 19:21:10 GMT 2025 , Edited by admin on Mon Mar 31 19:21:10 GMT 2025
PRIMARY
EPA CompTox
DTXSID8057774
Created by admin on Mon Mar 31 19:21:10 GMT 2025 , Edited by admin on Mon Mar 31 19:21:10 GMT 2025
PRIMARY
SMS_ID
100000087851
Created by admin on Mon Mar 31 19:21:10 GMT 2025 , Edited by admin on Mon Mar 31 19:21:10 GMT 2025
PRIMARY
ECHA (EC/EINECS)
226-964-4
Created by admin on Mon Mar 31 19:21:10 GMT 2025 , Edited by admin on Mon Mar 31 19:21:10 GMT 2025
PRIMARY
INN
1634
Created by admin on Mon Mar 31 19:21:10 GMT 2025 , Edited by admin on Mon Mar 31 19:21:10 GMT 2025
PRIMARY
FDA UNII
8T66I31YNK
Created by admin on Mon Mar 31 19:21:10 GMT 2025 , Edited by admin on Mon Mar 31 19:21:10 GMT 2025
PRIMARY
EVMPD
SUB05305MIG
Created by admin on Mon Mar 31 19:21:10 GMT 2025 , Edited by admin on Mon Mar 31 19:21:10 GMT 2025
PRIMARY
NCI_THESAURUS
C76519
Created by admin on Mon Mar 31 19:21:10 GMT 2025 , Edited by admin on Mon Mar 31 19:21:10 GMT 2025
PRIMARY
RXCUI
23161
Created by admin on Mon Mar 31 19:21:10 GMT 2025 , Edited by admin on Mon Mar 31 19:21:10 GMT 2025
PRIMARY RxNorm
CAS
5579-81-7
Created by admin on Mon Mar 31 19:21:10 GMT 2025 , Edited by admin on Mon Mar 31 19:21:10 GMT 2025
PRIMARY
MESH
C017231
Created by admin on Mon Mar 31 19:21:10 GMT 2025 , Edited by admin on Mon Mar 31 19:21:10 GMT 2025
PRIMARY
MERCK INDEX
m1486
Created by admin on Mon Mar 31 19:21:10 GMT 2025 , Edited by admin on Mon Mar 31 19:21:10 GMT 2025
PRIMARY Merck Index
Related Record Type Details
ACTIVE MOIETY