Opugotamig Olatansine

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 11:01:06 GMT 2025` Edited by `admin` on `Wed Apr 02 11:01:06 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY CONJUGATE
Protein Sub Type	IGG1\|KAPPA
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	8R9DRT37YD
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Opugotamig Olatansine

Official Name

English

Immunoglobulin, anti-(human folate receptor ?) (human-Mus musculus monoclonal FR1-57 single-chain Fv fragment VL-(GGGGS)4-VH)fusion protein with peptide linker (GS) fusion protein with immunoglobulin G1 [4-serine,151-tryptophan,de-232-lysine] (human ?1-c

Preferred Name

English

opugotamig olatansine [INN]

Common Name

English

immunoglobulin (G1_L-kappa)_scFvkh-G1(h-CH2-CH3), anti-[Homo sapiens FOLR1 (folate receptor 1, folate receptor alpha, FRalpha, adult folate-binding protein, FBP, ovarian tumor-associated antigen MOv18)], biparatopic, assymetric, bivalent; conjugated, on

Common Name

English

Code System Code Type Description

INN

12957

Created by admin on Wed Apr 02 11:01:06 GMT 2025 , Edited by admin on Wed Apr 02 11:01:06 GMT 2025

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SMS_ID

300000050593

Created by admin on Wed Apr 02 11:01:06 GMT 2025 , Edited by admin on Wed Apr 02 11:01:06 GMT 2025

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NCI_THESAURUS

C191851

Created by admin on Wed Apr 02 11:01:06 GMT 2025 , Edited by admin on Wed Apr 02 11:01:06 GMT 2025

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FDA UNII

8R9DRT37YD

Created by admin on Wed Apr 02 11:01:06 GMT 2025 , Edited by admin on Wed Apr 02 11:01:06 GMT 2025

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CAS

2779564-40-6

Created by admin on Wed Apr 02 11:01:06 GMT 2025 , Edited by admin on Wed Apr 02 11:01:06 GMT 2025

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From	To
1_400	1_458
1_294	1_354
3_138	3_198
3_23	3_92
2_368	2_426
2_262	2_322
1_262	2_230
1_259	2_227
2_221	3_218
2_145	2_201
2_22	2_96

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_330
N	2_298

Related Record Type Details


					ZQ8438KPJ4

PARENT -> CONJUGATE

Amount:

Related Record Type Details


					8R9DRT37YD

Opugotamig Olatansine

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[2_1]	N-TERMINUS			PIDOLIC ACID	SZB83O1W42
AMINO_ACID_SUBSTITUTION		RESIDUE_SPECIFIC	K	Amount:	Lysinyl olatansine	V4MU4H7BAS

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL