Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | 2C4H7O5.Mg.H2O |
| Molecular Weight | 312.511 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O.[Mg++].OC[C@H](O)[C@@H](O)C([O-])=O.OC[C@H](O)[C@@H](O)C([O-])=O
InChI
InChIKey=WUTXTCBGTJDODK-YKSMAXERSA-L
InChI=1S/2C4H8O5.Mg.H2O/c2*5-1-2(6)3(7)4(8)9;;/h2*2-3,5-7H,1H2,(H,8,9);;1H2/q;;+2;/p-2/t2*2-,3+;;/m00../s1
| Molecular Formula | C4H7O5 |
| Molecular Weight | 135.0954 |
| Charge | -1 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
| Molecular Formula | Mg |
| Molecular Weight | 24.305 |
| Charge | 2 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | H2O |
| Molecular Weight | 18.0153 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/6684626 | https://www.ncbi.nlm.nih.gov/pubmed/10420182 | http://www.hmdb.ca/metabolites/HMDB0000943https://www.ncbi.nlm.nih.gov/pubmed/28306698 | https://www.cancer.gov/publications/dictionaries/cancer-drug/def/magnesium-l-threonate | https://www.ncbi.nlm.nih.gov/pubmed/30829204
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6684626 | https://www.ncbi.nlm.nih.gov/pubmed/10420182 | http://www.hmdb.ca/metabolites/HMDB0000943https://www.ncbi.nlm.nih.gov/pubmed/28306698 | https://www.cancer.gov/publications/dictionaries/cancer-drug/def/magnesium-l-threonate | https://www.ncbi.nlm.nih.gov/pubmed/30829204
Magnesium L-Threonate (MgT) is the most appropriate Mg salt that strengthens the cholinergic system and improves brain-related functions. It is used to improve memory, assist with sleep, and to enhance overall cognitive function. Mg, an intracellular cofactor for many enzymes, is a modulator of the N-methyl-D-aspartate (NMDA) receptor that is involved in memory function and depression. Experiments on rodents have shown that oral magnesium-L-Threonate also prevents neuropathic pain induced by chemotherapy.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Neurobehavioral and biochemical effects of magnesium chloride (MgCl2), magnesium sulphate (MgSO4) and magnesium-L-threonate (MgT) supplementation in rats: A dose dependent comparative study. | 2019-01 |
|
| Defective methionine metabolism in the brain after repeated blast exposures might contribute to increased oxidative stress. | 2018-01 |
|
| Distinct metabolomic signature in cerebrospinal fluid in early parkinson's disease. | 2017-10 |
|
| Oral Application of Magnesium-L-Threonate Attenuates Vincristine-induced Allodynia and Hyperalgesia by Normalization of Tumor Necrosis Factor-α/Nuclear Factor-κB Signaling. | 2017-06 |
|
| Magnesium L-threonate prevents and restores memory deficits associated with neuropathic pain by inhibition of TNF-α. | 2013-10-01 |
|
| Chronic dietary magnesium-L-threonate speeds extinction and reduces spontaneous recovery of a conditioned taste aversion. | 2013-05 |
|
| Evaluation of a sunscreen photoprotective effect by ascorbic acid assessment in human dermis using microdialysis and gas chromatography mass spectrometry. | 2005-03 |
|
| Sugars including erythronic and threonic acids in human aqueous humour. | 1999-08 |
Sample Use Guides
When administered orally to guinea-pigs (100 mg/kg body weight) for periods of 4 or 28 days, sodium threonate (threonic acid) produced a significant fall in the ascorbic acid concentration of certain organs but was without effect on other physiological and biochemical characteristics. The lifespan of scorbutic guinea-pigs was significantly reduced by dietary threonic acid (100 mg/kg body weight)
Route of Administration:
Oral
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 22:55:19 GMT 2025
by
admin
on
Mon Mar 31 22:55:19 GMT 2025
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| Record UNII |
8R67P63UCG
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| Record Status |
Validated (UNII)
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| Record Version |
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| Related Record | Type | Details | ||
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PARENT -> SALT/SOLVATE |
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ANHYDROUS->SOLVATE |
