MAGNESIUM L-THREONATE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	2C4H7O5.Mg
Molecular Weight	294.4958
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Mg++].OC[C@H](O)[C@@H](O)C([O-])=O.OC[C@H](O)[C@@H](O)C([O-])=O

InChI

InChIKey=YVJOHOWNFPQSPP-BALCVSAKSA-L

InChI=1S/2C4H8O5.Mg/c2*5-1-2(6)3(7)4(8)9;/h2*2-3,5-7H,1H2,(H,8,9);/q;;+2/p-2/t2*2-,3+;/m00./s1

HIDE SMILES / InChI

Molecular Formula	Mg
Molecular Weight	24.305
Charge	2
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C4H7O5
Molecular Weight	135.0954
Charge	-1
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6684626 | https://www.ncbi.nlm.nih.gov/pubmed/10420182 | http://www.hmdb.ca/metabolites/HMDB0000943https://www.ncbi.nlm.nih.gov/pubmed/28306698 | https://www.cancer.gov/publications/dictionaries/cancer-drug/def/magnesium-l-threonate | https://www.ncbi.nlm.nih.gov/pubmed/30829204

Magnesium L-Threonate (MgT) is the most appropriate Mg salt that strengthens the cholinergic system and improves brain-related functions. It is used to improve memory, assist with sleep, and to enhance overall cognitive function. Mg, an intracellular cofactor for many enzymes, is a modulator of the N-methyl-D-aspartate (NMDA) receptor that is involved in memory function and depression. Experiments on rodents have shown that oral magnesium-L-Threonate also prevents neuropathic pain induced by chemotherapy.

Approval Year

PubMed

Title	Date	PubMed
Neurobehavioral and biochemical effects of magnesium chloride (MgCl2), magnesium sulphate (MgSO4) and magnesium-L-threonate (MgT) supplementation in rats: A dose dependent comparative study.	2019-01	30829204
Defective methionine metabolism in the brain after repeated blast exposures might contribute to increased oxidative stress.	2018-01	28774719
Distinct metabolomic signature in cerebrospinal fluid in early parkinson's disease.	2017-10	28843022
Oral Application of Magnesium-L-Threonate Attenuates Vincristine-induced Allodynia and Hyperalgesia by Normalization of Tumor Necrosis Factor-α/Nuclear Factor-κB Signaling.	2017-06	28306698
Magnesium L-threonate prevents and restores memory deficits associated with neuropathic pain by inhibition of TNF-α.	2013-10-01	24077207
Chronic dietary magnesium-L-threonate speeds extinction and reduces spontaneous recovery of a conditioned taste aversion.	2013-05	23474371
Evaluation of a sunscreen photoprotective effect by ascorbic acid assessment in human dermis using microdialysis and gas chromatography mass spectrometry.	2005-03	15740589
Sugars including erythronic and threonic acids in human aqueous humour.	1999-08	10420182

Sample Use Guides

In Vivo Use Guide

When administered orally to guinea-pigs (100 mg/kg body weight) for periods of 4 or 28 days, sodium threonate (threonic acid) produced a significant fall in the ascorbic acid concentration of certain organs but was without effect on other physiological and biochemical characteristics. The lifespan of scorbutic guinea-pigs was significantly reduced by dietary threonic acid (100 mg/kg body weight)

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Mon Mar 31 22:55:18 GMT 2025` Edited by `admin` on `Mon Mar 31 22:55:18 GMT 2025`
Record UNII	1Y26ZZ0OTM
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MAGNESIUM L-THREONATE

Common Name

English

MAGNESIUM L-THREONATE ANHYDROUS

Preferred Name

English

Magnesium l-threonate [WHO-DD]

Common Name

English

MAGNESIUM, BIS((2R,3S)-2,3,4-TRIHYDROXYBUTANOATO-.KAPPA.O,.KAPPA.O')-, (T-4)-

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29697