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Details

Stereochemistry ACHIRAL
Molecular Formula C27H58N2O3.2FH
Molecular Weight 498.7737
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of OLAFLUR

SMILES

F.F.CCCCCCCCCCCCCCCCCCN(CCO)CCCN(CCO)CCO

InChI

InChIKey=ZVVSSOQAYNYNPP-UHFFFAOYSA-N
InChI=1S/C27H58N2O3.2FH/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-19-28(22-25-30)20-18-21-29(23-26-31)24-27-32;;/h30-32H,2-27H2,1H3;2*1H

HIDE SMILES / InChI

Molecular Formula FH
Molecular Weight 20.0063
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C27H58N2O3
Molecular Weight 458.761
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including https://www.drugs.com/international/olaflur.html | https://www.ncbi.nlm.nih.gov/pubmed/15528912 | https://clinicaltrials.gov/ct2/show/record/NCT00268138 | https://www.old.health.gov.il/units/pharmacy/trufot/alonim/4872.pdf

Oleylamine (or oleamine) is a versatile and flexible reagent in synthesis as well as the desired surface ligand for the synthesis of nanoparticles. This compound is rather toxic to mammalian organism.

CNS Activity

Originator

Sources: Helvetica Odontologica Acta (1962), 6, (1), 15-20.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
elmex

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Successful extracorporeal life support after potentially fatal pulmonary oedema caused by inhalation of nitric and hydrofluoric acid fumes.
2007 Oct
Sensitivity of human dental pulp cells to eighteen chemical agents used for endodontic treatments in dentistry.
2013 Jan
Cytotoxicity of organic surface coating agents used for nanoparticles synthesis and stability.
2015 Jun
Allergic contact cheilitis caused by olaflur in toothpaste.
2017 Jan
Patents

Patents

Sample Use Guides

Brushing your teeth thoroughly with the preparation once a week. Just use elmex dental gel using a regular toothbrush for a period of 2-3 minutes, rinse normally. The total time of application (brushing and residence time) should not exceed five minutes.
Route of Administration: Dental
In Vitro Use Guide
The outer 50-100 mkm of the surface of freshly extracted human incisors was removed by grinding and polishing, thus removing not only the pellicle from the surface but also the outer mineral layer, which in general shows the greatest variation in chemical constituents. Amine fluoride 297 (AmF 297) were dissolved in distilled water. After adsorption of aminefluorides on the enamel for 2 min at a volume to area ratio of 25 cm3/cm2, the enamel surfaces were rinsed with distilled water and allowed to dry for several hours at room temperature in an enclosed chamber. Subsequently adsorbed layer thicknesses were determined by ellipsometry, and surface free energies were calculated from contact angle data.
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:48:08 GMT 2023
Edited
by admin
on Fri Dec 15 15:48:08 GMT 2023
Record UNII
8NY9L8837D
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
OLAFLUR
INCI   INN   MART.   MI   USAN   WHO-DD  
INCI   USAN   INN  
Official Name English
Olaflur [WHO-DD]
Common Name English
ETHANOL, 2,2'-((3-((2-HYDROXYETHYL)OCTADECYLAMINO)PROPYL)IMINO)BIS-, DIHYDROFLUORIDE
Common Name English
OLAFLUR [INCI]
Common Name English
olaflur [INN]
Common Name English
OLAFLUR [MI]
Common Name English
SK&F-38095
Code English
OLAFLUR [USAN]
Common Name English
SKF-38095
Code English
OLAFLUR [MART.]
Common Name English
2,2'-((3-((2-HYDROXYETHYL)OCTADECYLAMINO)PROPYL)IMINO)DIETHANOL DIHYDROFLUORIDE
Systematic Name English
OLAFUR
Common Name English
SK&F 38095
Code English
Classification Tree Code System Code
WHO-ATC A01AA03
Created by admin on Fri Dec 15 15:48:08 GMT 2023 , Edited by admin on Fri Dec 15 15:48:08 GMT 2023
WHO-VATC QA01AA03
Created by admin on Fri Dec 15 15:48:09 GMT 2023 , Edited by admin on Fri Dec 15 15:48:09 GMT 2023
Code System Code Type Description
MESH
C495399
Created by admin on Fri Dec 15 15:48:09 GMT 2023 , Edited by admin on Fri Dec 15 15:48:09 GMT 2023
PRIMARY
CAS
6818-37-7
Created by admin on Fri Dec 15 15:48:08 GMT 2023 , Edited by admin on Fri Dec 15 15:48:08 GMT 2023
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PUBCHEM
23257
Created by admin on Fri Dec 15 15:48:09 GMT 2023 , Edited by admin on Fri Dec 15 15:48:09 GMT 2023
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DRUG BANK
DB13290
Created by admin on Fri Dec 15 15:48:08 GMT 2023 , Edited by admin on Fri Dec 15 15:48:08 GMT 2023
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ECHA (EC/EINECS)
229-891-6
Created by admin on Fri Dec 15 15:48:08 GMT 2023 , Edited by admin on Fri Dec 15 15:48:08 GMT 2023
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FDA UNII
8NY9L8837D
Created by admin on Fri Dec 15 15:48:09 GMT 2023 , Edited by admin on Fri Dec 15 15:48:09 GMT 2023
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DRUG CENTRAL
4311
Created by admin on Fri Dec 15 15:48:08 GMT 2023 , Edited by admin on Fri Dec 15 15:48:08 GMT 2023
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EVMPD
SUB09425MIG
Created by admin on Fri Dec 15 15:48:08 GMT 2023 , Edited by admin on Fri Dec 15 15:48:08 GMT 2023
PRIMARY
ChEMBL
CHEMBL2110901
Created by admin on Fri Dec 15 15:48:08 GMT 2023 , Edited by admin on Fri Dec 15 15:48:08 GMT 2023
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SMS_ID
100000083292
Created by admin on Fri Dec 15 15:48:09 GMT 2023 , Edited by admin on Fri Dec 15 15:48:09 GMT 2023
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INN
3375
Created by admin on Fri Dec 15 15:48:09 GMT 2023 , Edited by admin on Fri Dec 15 15:48:09 GMT 2023
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MERCK INDEX
m8182
Created by admin on Fri Dec 15 15:48:09 GMT 2023 , Edited by admin on Fri Dec 15 15:48:09 GMT 2023
PRIMARY Merck Index
NCI_THESAURUS
C175173
Created by admin on Fri Dec 15 15:48:09 GMT 2023 , Edited by admin on Fri Dec 15 15:48:09 GMT 2023
PRIMARY
WIKIPEDIA
OLAFLUR
Created by admin on Fri Dec 15 15:48:09 GMT 2023 , Edited by admin on Fri Dec 15 15:48:09 GMT 2023
PRIMARY
EPA CompTox
DTXSID40987684
Created by admin on Fri Dec 15 15:48:08 GMT 2023 , Edited by admin on Fri Dec 15 15:48:08 GMT 2023
PRIMARY
Related Record Type Details
ACTIVE MOIETY