DILOXANIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C9H9Cl2NO2
Molecular Weight	234.079
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN(C(=O)C(Cl)Cl)C1=CC=C(O)C=C1

InChI

InChIKey=GZZZSOOGQLOEOB-UHFFFAOYSA-N

InChI=1S/C9H9Cl2NO2/c1-12(9(14)8(10)11)6-2-4-7(13)5-3-6/h2-5,8,13H,1H3

HIDE SMILES / InChI

Molecular Formula	C9H9Cl2NO2
Molecular Weight	234.079
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.fda.gov/ohrms/dockets/dockets/98n0182/nom003b.pdf

Diloxanide (used in the form of furoate) was developed for the treatment of intestinal amoebiasis. The effectiveness of the drug was proved in clinical trials, however, the mechanism of its action is unknown. The drug is not marketed in the United States, athough it is available in India.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Amebiasis 11 Sources: http://www.tm.mahidol.ac.th/pediatrics/sites/default/files/Antiparasitic-drugs.pdf	Curative		Approved 8429	DILOXANIDE FUROATE Approved Use Unknown

PubMed

Title	Date	PubMed
Stability studies on diloxanide furoate: effect of pH, temperature, gastric and intestinal fluids.	2004 Apr	15081350
Invasive amoebiasis complicating iflammatory bowel disease.	2007 Dec 1	21503247
RPLC Determination of Tinidazole and Diloxanide Furoate in Tablets.	2008 Sep	21394273
Difficulties in the treatment of intestinal amoebiasis in mentally disabled individuals at a rehabilitation institution for the intellectually impaired in Japan.	2010	20720419

Patents

Sample Use Guides

In Vivo Use Guide

500mg 3 times daily for 5 days or 20mg/kg/daily divided into 3 daily doses for 10 days.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Sat Dec 16 16:55:52 UTC 2023` Edited by `admin` on `Sat Dec 16 16:55:52 UTC 2023`
Record UNII	89134SCM7M
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DILOXANIDE

Official Name

English

Diloxanide [WHO-DD]

Common Name

English

diloxanide [INN]

Common Name

English

2,2-DICHLORO-4'-HYDROXY-N-METHYLACETANILIDE

Systematic Name

English

DILOXANIDE [MI]

Common Name

English

Classification Tree Code System Code

WHO-ESSENTIAL MEDICINES LIST

6.5.1