GLYSOBUZOLE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C13H17N3O3S2
Molecular Weight	327.422
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC=C(C=C1)S(=O)(=O)NC2=NN=C(CC(C)C)S2

InChI

InChIKey=LZCBNYVJTNCPDR-UHFFFAOYSA-N

InChI=1S/C13H17N3O3S2/c1-9(2)8-12-14-15-13(20-12)16-21(17,18)11-6-4-10(19-3)5-7-11/h4-7,9H,8H2,1-3H3,(H,15,16)

HIDE SMILES / InChI

Molecular Formula	C13H17N3O3S2
Molecular Weight	327.422
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=NCI_Thesaurus&code=C65813 | https://www.ncbi.nlm.nih.gov/pubmed/14400418

Glysobuzole (stabinol) is a sulfonamide derivative with antihyperglycemic activity. Like sulfonylureas, glysobuzole is able to lower blood glucose levels by increasing the release of insulin from pancreatic beta cells.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
insulin metabolic process 1 Target ID: GO:1901142 Sources: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=NCI_Thesaurus&code=C65813	Modulator 828

Conditions

Condition	Modality	Targets	Highest Phase	Product
Diabetes mellitus 91 Sources: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=NCI_Thesaurus&code=C65813 https://www.ncbi.nlm.nih.gov/pubmed/14400418	Primary		Not Provided 504	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Preliminary observations on management of diabetes with "stabinol".	1960 Sep 24	14400418

Patents

Sample Use Guides

In Vivo Use Guide

Diabetes patients were started on four tablets of 250 mg (1 g) of stabinol (given in a single dose in the morning).

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Sat Dec 16 16:58:56 GMT 2023` Edited by `admin` on `Sat Dec 16 16:58:56 GMT 2023`
Record UNII	887VHL8899
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

GLYSOBUZOLE

Official Name

English

ISOBUZOLE

Common Name

English

glysobuzole [INN]

Common Name

English

Glysobuzole [WHO-DD]

Common Name

English

BENZENESULFONAMIDE, 4-METHOXY-N-(5-(2-METHYLPROPYL)-1,3,4-THIADIAZOL-2-YL)-

Systematic Name

English

8002 C. B.

Code

English

STABINOL

Brand Name

English

NSC-34014

Code

English

N-(5-ISOBUTYL-1,3,4-THIADIAZOL-2-YL)-P-METHOXYBENZENESULFONAMIDE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29711