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Details

Stereochemistry ACHIRAL
Molecular Formula C22H18I6N2O9
Molecular Weight 1215.8131
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of IOTROXIC ACID

SMILES

OC(=O)C1=C(I)C(NC(=O)COCCOCCOCC(=O)NC2=C(I)C=C(I)C(C(O)=O)=C2I)=C(I)C=C1I

InChI

InChIKey=JXMIBUGMYLQZGO-UHFFFAOYSA-N
InChI=1S/C22H18I6N2O9/c23-9-5-11(25)19(17(27)15(9)21(33)34)29-13(31)7-38-3-1-37-2-4-39-8-14(32)30-20-12(26)6-10(24)16(18(20)28)22(35)36/h5-6H,1-4,7-8H2,(H,29,31)(H,30,32)(H,33,34)(H,35,36)

HIDE SMILES / InChI

Molecular Formula C22H18I6N2O9
Molecular Weight 1215.8131
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Iotroxic acid (INN), also known as meglumine iotroxate (BAN) (Biliscopin) for infusion is indicated for radiological examination of the hepatic and biliary ducts and gallbladder when examination by oral technique is unsuccessful or inappropriate. Following intravenous administration Biliscopin is rapidly excreted, mainly by the liver into the bile. Visualisation of the hepatic and common bile ducts and the gallbladder can, therefore, be achieved. Visualisation of the biliary ducts is usually possible 30-60 minutes after completion of administration. In vitro meglumine iotroxate binds to plasma proteins to the extent of 60-90% depending on concentration. In animals it crosses the placental barrier. This agent is the single intravenous cholangiographic agent, which is currently available in Australia.

Approval Year

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
Biliscopin

T1/2

ValueDoseCo-administeredAnalytePopulation
1.4 h
70 mg/kg single, intravenous
IOTROXIC ACID blood
Homo sapiens
1.8 h
112 mg/kg single, intravenous
IOTROXIC ACID blood
Homo sapiens

Funbound

ValueDoseCo-administeredAnalytePopulation
8.19%
IOTROXIC ACID plasma
Homo sapiens

Doses

PubMed

Sample Use Guides

In Vivo Use Guide
One bottle (100 mL) for infusion (1 mL=20 drops)
Route of Administration: Intravenous
In Vitro Use Guide
Unknown
Substance Class Chemical
Record UNII
84C5PTP9X6
Record Status Validated (UNII)
Record Version