PAMIPARIB

C[C@]12CCCN1CC3=NNC(=O)C4=C5C(NC2=C35)=CC(F)=C4

InChIKey=DENYZIUJOTUUNY-MRXNPFEDSA-N

InChI=1S/C16H15FN4O/c1-16-3-2-4-21(16)7-11-13-12-9(15(22)20-19-11)5-8(17)6-10(12)18-14(13)16/h5-6,18H,2-4,7H2,1H3,(H,20,22)/t16-/m1/s1

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Targets

Primary Target	Pharmacology	Condition	Potency
Poly [ADP-ribose] polymerase-1 23 Target ID: CHEMBL3105 Sources: https://www.beigene.com/science-and-product-portfolio/pipeline/pamiparib \| https://cancerres.aacrjournals.org/content/75/15_Supplement/1653 \| https://patents.google.com/patent/WO2013097225A1	Inhibitor 8297		0.83 nM [IC50]
Poly [ADP-ribose] polymerase 2 16 Target ID: CHEMBL5366 Sources: https://www.beigene.com/science-and-product-portfolio/pipeline/pamiparib \| https://cancerres.aacrjournals.org/content/75/15_Supplement/1653 \| https://patents.google.com/patent/WO2013097225A1	Inhibitor 8297		0.11 nM [IC50]

PubMed

Title	Date	PubMed
Pamiparib in combination with tislelizumab in patients with advanced solid tumours: results from the dose-escalation stage of a multicentre, open-label, phase 1a/b trial.	2019 Sep	31378459

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 10:40:46 UTC 2023` Edited by `admin` on `Sat Dec 16 10:40:46 UTC 2023`
Record UNII	8375F9S90C
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

PAMIPARIB

Official Name

English

5,6,7A,11-TETRAAZACYCLOHEPTA(DEF)CYCLOPENTA(A)FLUOREN-4(7H)-ONE, 2-FLUORO-5,8,9,10,10A,11-HEXAHYDRO-10A-METHYL-, (10AR)-

Systematic Name

English

Pamiparib [WHO-DD]

Common Name

English

PAMIPARIB [USAN]

Common Name

English

pamiparib [INN]

Common Name

English

BGB-290

Code

English

(10aR)-2-Fluoro-10a-methyl-5,8,9,10,10a,11-hexahydro-5,6,7a,11-tetraazacyclohepta[def]cyclopenta[a]fluoren-4(7H)-one

Systematic Name

English

Code System Code Type Description

USAN

FG-155