CEDEFINGOL

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C20H41NO3
Molecular Weight	343.5444
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCCCCCCCCCCCCC[C@H](O)[C@H](CO)NC(C)=O

InChI

InChIKey=CRJGESKKUOMBCT-PMACEKPBSA-N

InChI=1S/C20H41NO3/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-20(24)19(17-22)21-18(2)23/h19-20,22,24H,3-17H2,1-2H3,(H,21,23)/t19-,20-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C20H41NO3
Molecular Weight	343.5444
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: http://adisinsight.springer.com/drugs/800004732
Curator's Comment: The description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/8253743

Cedefingol is a derivative of sphingosine, with potential antineoplastic activity. As a sphingosine derivative, cedefingol appears to inhibit protein kinase C (PKC), a kinase that plays an important role in tumorigenesis.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Protein kinase C, PKC; classical/novel 4 Target ID: CHEMBL2096620 Sources: http://adisinsight.springer.com/drugs/800004732	Inhibitor 8297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Psoriasis 84 Sources: http://www.google.com/patents/US20090275099	Primary		Preclinical	Unknown Approved Use Unknown
Cancer 592 Sources: http://adisinsight.springer.com/drugs/800004732	Primary		Preclinical	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Selectivity of ceramide-mediated biology. Lack of activity of erythro-dihydroceramide.	1993 Dec 15	8253743

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

HL-60 human myelocytic leukemia cells were grown as described and treated with [3H]C2-ceramidesa t concentrations ranging from 1 to 10 mkM. At the indicated time points, pellets were separated from media and 3H radioactivity was counted.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:28:55 GMT 2023` Edited by `admin` on `Fri Dec 15 16:28:55 GMT 2023`
Record UNII	81HH79X39W
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CEDEFINGOL

Official Name

English

N-[(1S,2S)-2-Hydroxy-1-(hydroxymethyl)heptadecyl]acetamide

Systematic Name

English

SPC-10121O

Code

English

SPC-101210

Code

English

cedefingol [INN]

Common Name

English

CEDEFINGOL [USAN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C274