LEVOXADROL

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C20H23NO2
Molecular Weight	309.4021
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of LEVOXADROL

Structure Search

SMILES

[H][C@]1(COC(O1)(C2=CC=CC=C2)C3=CC=CC=C3)[C@@]4([H])CCCCN4

InChI

InChIKey=HGKAMARNFGKMLC-MOPGFXCFSA-N

InChI=1S/C20H23NO2/c1-3-9-16(10-4-1)20(17-11-5-2-6-12-17)22-15-19(23-20)18-13-7-8-14-21-18/h1-6,9-12,18-19,21H,7-8,13-15H2/t18-,19+/m1/s1

HIDE SMILES / InChI

Molecular Formula	C20H23NO2
Molecular Weight	309.4021
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2555461

Levoxadrol is an active enantiomer of dexoxadrol.

Approval Year

Conditions

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2578

PubMed

PubMed

Title	Date	PubMed
Stereospecific binding of 3H-phencyclidine in brain membranes.	1982 Jun 21	7109842
Characterization of specific sigma opiate/phencyclidine (PCP)-binding sites in the human brain.	1983	6319873
Comparison of the effects of the acute administration of dexoxadrol, levoxadrol, MK-801 and phencyclidine on body temperature in the rat.	1989 Aug	2674766
Phencyclidine binds to blood platelets with high affinity and specifically inhibits their activation by adrenaline.	1992 Jul 1	1322125

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:43:52 GMT 2023` Edited by `admin` on `Fri Dec 15 15:43:52 GMT 2023`
Record UNII	811X558HU0
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

LEVOXADROL

Official Name

English

levoxadrol [INN]

Common Name

English

PIPERIDINE, 2-((4R)-2,2-DIPHENYL-1,3-DIOXOLAN-4-YL)-, (2R)-

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C241

Created by admin on Fri Dec 15 15:43:52 GMT 2023 , Edited by admin on Fri Dec 15 15:43:52 GMT 2023

Code System Code Type Description

CAS

4792-18-1

Created by admin on Fri Dec 15 15:43:52 GMT 2023 , Edited by admin on Fri Dec 15 15:43:52 GMT 2023

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FDA UNII

811X558HU0

Created by admin on Fri Dec 15 15:43:52 GMT 2023 , Edited by admin on Fri Dec 15 15:43:52 GMT 2023

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MESH

C005840

Created by admin on Fri Dec 15 15:43:52 GMT 2023 , Edited by admin on Fri Dec 15 15:43:52 GMT 2023

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PUBCHEM

14208378

Created by admin on Fri Dec 15 15:43:52 GMT 2023 , Edited by admin on Fri Dec 15 15:43:52 GMT 2023

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INN

1503

Created by admin on Fri Dec 15 15:43:52 GMT 2023 , Edited by admin on Fri Dec 15 15:43:52 GMT 2023

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NCI_THESAURUS

C66010

Created by admin on Fri Dec 15 15:43:52 GMT 2023 , Edited by admin on Fri Dec 15 15:43:52 GMT 2023

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EPA CompTox

DTXSID801023588

Created by admin on Fri Dec 15 15:43:52 GMT 2023 , Edited by admin on Fri Dec 15 15:43:52 GMT 2023

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SMS_ID

100000082305

Created by admin on Fri Dec 15 15:43:52 GMT 2023 , Edited by admin on Fri Dec 15 15:43:52 GMT 2023

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EVMPD

SUB08496MIG

Created by admin on Fri Dec 15 15:43:52 GMT 2023 , Edited by admin on Fri Dec 15 15:43:52 GMT 2023

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ChEMBL

CHEMBL306386

Created by admin on Fri Dec 15 15:43:52 GMT 2023 , Edited by admin on Fri Dec 15 15:43:52 GMT 2023

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Related Record Type Details


					3ARD9VMM81

LEVOXADROL HYDROCHLORIDE

SALT/SOLVATE -> PARENT

Related Record Type Details


					811X558HU0

ACTIVE MOIETY