LEVOXADROL

[H][C@]1(COC(O1)(C2=CC=CC=C2)C3=CC=CC=C3)[C@@]4([H])CCCCN4

InChIKey=HGKAMARNFGKMLC-MOPGFXCFSA-N

InChI=1S/C20H23NO2/c1-3-9-16(10-4-1)20(17-11-5-2-6-12-17)22-15-19(23-20)18-13-7-8-14-21-18/h1-6,9-12,18-19,21H,7-8,13-15H2/t18-,19+/m1/s1

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Levoxadrol is an active enantiomer of dexoxadrol.

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2578

PubMed

Title	Date	PubMed
Stereospecific binding of 3H-phencyclidine in brain membranes.	1982 Jun 21	7109842
Characterization of specific sigma opiate/phencyclidine (PCP)-binding sites in the human brain.	1983	6319873
Psychotomimetic sigma-ligands, dexoxadrol and phencyclidine block the same presynaptic potassium channel in rat brain.	1988 Sep	3253423
Comparison of the effects of the acute administration of dexoxadrol, levoxadrol, MK-801 and phencyclidine on body temperature in the rat.	1989 Aug	2674766
Interaction of phencyclidine with voltage-dependent potassium channels in cultured rat hippocampal neurons: comparison with block of the NMDA receptor-ionophore complex.	1989 Nov	2555461
Phencyclidine binds to blood platelets with high affinity and specifically inhibits their activation by adrenaline.	1992 Jul 1	1322125

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:43:52 GMT 2023` Edited by `admin` on `Fri Dec 15 15:43:52 GMT 2023`
Record UNII	811X558HU0
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

LEVOXADROL

Official Name

English

levoxadrol [INN]

Common Name

English

PIPERIDINE, 2-((4R)-2,2-DIPHENYL-1,3-DIOXOLAN-4-YL)-, (2R)-

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C241