LEVOXADROL HYDROCHLORIDE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C20H23NO2.ClH
Molecular Weight	345.863
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.C1OC(O[C@@H]1[C@H]2CCCCN2)(C3=CC=CC=C3)C4=CC=CC=C4

InChI

InChIKey=GYPWNVSWCIMIHQ-VOMIJIAVSA-N

InChI=1S/C20H23NO2.ClH/c1-3-9-16(10-4-1)20(17-11-5-2-6-12-17)22-15-19(23-20)18-13-7-8-14-21-18;/h1-6,9-12,18-19,21H,7-8,13-15H2;1H/t18-,19+;/m1./s1

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C20H23NO2
Molecular Weight	309.4021
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2555461

Levoxadrol is an active enantiomer of dexoxadrol.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2596

PubMed

Title	Date	PubMed
Phencyclidine binds to blood platelets with high affinity and specifically inhibits their activation by adrenaline.	1992-07-01	1322125
Interaction of phencyclidine with voltage-dependent potassium channels in cultured rat hippocampal neurons: comparison with block of the NMDA receptor-ionophore complex.	1989-11	2555461
Comparison of the effects of the acute administration of dexoxadrol, levoxadrol, MK-801 and phencyclidine on body temperature in the rat.	1989-08	2674766
Psychotomimetic sigma-ligands, dexoxadrol and phencyclidine block the same presynaptic potassium channel in rat brain.	1988-09	3253423
Coexpression of N-methyl-D-aspartate and phencyclidine receptors in Xenopus oocytes injected with rat brain mRNA.	1988-05	2834739
Effects of phencyclidine, SKF 10,047 and related psychotomimetic agents on N-methyl-D-aspartate receptor mediated synaptic responses in rat hippocampal slices.	1987-07	3038243
Characterization of specific sigma opiate/phencyclidine (PCP)-binding sites in the human brain.	1983	6319873
Stereospecific binding of 3H-phencyclidine in brain membranes.	1982-06-21	7109842

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:45:33 GMT 2025` Edited by `admin` on `Mon Mar 31 17:45:33 GMT 2025`
Record UNII	3ARD9VMM81
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

LEVOXAN

Preferred Name

English

LEVOXADROL HYDROCHLORIDE

Official Name

English

NIH-10374

Code

English

CL-912C

Code

English

(-)-2-(2,2-DIPHENYL-1,3-DIOXOLAN-4-YL)PIPERIDINE HYDROCHLORIDE

Systematic Name

English

LEVOXADROL HCL

Common Name

English

NSC-526063

Code

English

LEVOXADROL HYDROCHLORIDE [USAN]

Common Name

English

DIOXADROL L-FORM HYDROCHLORIDE [MI]

Common Name

English

NSC-526062

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C241