LEVOXADROL HYDROCHLORIDE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C20H23NO2.ClH
Molecular Weight	345.863
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.[H][C@]1(COC(O1)(C2=CC=CC=C2)C3=CC=CC=C3)[C@@]4([H])CCCCN4

InChI

InChIKey=GYPWNVSWCIMIHQ-VOMIJIAVSA-N

InChI=1S/C20H23NO2.ClH/c1-3-9-16(10-4-1)20(17-11-5-2-6-12-17)22-15-19(23-20)18-13-7-8-14-21-18;/h1-6,9-12,18-19,21H,7-8,13-15H2;1H/t18-,19+;/m1./s1

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C20H23NO2
Molecular Weight	309.4021
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2555461

Levoxadrol is an active enantiomer of dexoxadrol.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2578

PubMed

Title	Date	PubMed
Stereospecific binding of 3H-phencyclidine in brain membranes.	1982 Jun 21	7109842
Characterization of specific sigma opiate/phencyclidine (PCP)-binding sites in the human brain.	1983	6319873
Effects of phencyclidine, SKF 10,047 and related psychotomimetic agents on N-methyl-D-aspartate receptor mediated synaptic responses in rat hippocampal slices.	1987 Jul	3038243
Coexpression of N-methyl-D-aspartate and phencyclidine receptors in Xenopus oocytes injected with rat brain mRNA.	1988 May	2834739
Psychotomimetic sigma-ligands, dexoxadrol and phencyclidine block the same presynaptic potassium channel in rat brain.	1988 Sep	3253423
Comparison of the effects of the acute administration of dexoxadrol, levoxadrol, MK-801 and phencyclidine on body temperature in the rat.	1989 Aug	2674766
Interaction of phencyclidine with voltage-dependent potassium channels in cultured rat hippocampal neurons: comparison with block of the NMDA receptor-ionophore complex.	1989 Nov	2555461
Phencyclidine binds to blood platelets with high affinity and specifically inhibits their activation by adrenaline.	1992 Jul 1	1322125

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:04:32 GMT 2023` Edited by `admin` on `Fri Dec 15 15:04:32 GMT 2023`
Record UNII	3ARD9VMM81
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

LEVOXADROL HYDROCHLORIDE

Official Name

English

NIH-10374

Code

English

CL-912C

Code

English

LEVOXAN

Brand Name

English

(-)-2-(2,2-DIPHENYL-1,3-DIOXOLAN-4-YL)PIPERIDINE HYDROCHLORIDE

Systematic Name

English

LEVOXADROL HCL

Common Name

English

NSC-526063

Code

English

LEVOXADROL HYDROCHLORIDE [USAN]

Common Name

English

DIOXADROL L-FORM HYDROCHLORIDE [MI]

Common Name

English

NSC-526062

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C241