U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C19H27N3O3S
Molecular Weight 377.5028
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PRX-03140

SMILES

CC(C)n1c(=O)c(c(c2ccsc21)O)C(=O)NCCCN3CCCCC3

InChI

InChIKey=SCHKZZSVELPJKU-UHFFFAOYSA-N
InChI=1S/C19H27N3O3S/c1-13(2)22-18(25)15(16(23)14-7-12-26-19(14)22)17(24)20-8-6-11-21-9-4-3-5-10-21/h7,12-13,23H,3-6,8-11H2,1-2H3,(H,20,24)

HIDE SMILES / InChI

Molecular Formula C19H27N3O3S
Molecular Weight 377.5028
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

PRX-03140 is a partial agonist of the 5-HT4 receptor that is being developed by EPIX Pharmaceuticals for Alzheimer's disease. In vitro shows potent binding to 5-HT4 receptor and increased cAMP production in human embryonic kidney-293 cells expressing recombinant rat 5-HT(4) receptors. In the clinical trial, PRX-03140 was associated with a statistically significant improvement in the Alzheimer’s Disease Assessment Scale.

Approval Year

PubMed

PubMed

TitleDatePubMed
VRX-03011, a novel 5-HT4 agonist, enhances memory and hippocampal acetylcholine efflux.
2007 Sep
Patents

Sample Use Guides

50 mg PRX-03140 capsules once daily for 2 weeks. After 2 weeks, the dose will increase to 100mg PRX-03140 once daily for 10 weeks.
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Sat Jun 26 03:37:26 UTC 2021
Edited
by admin
on Sat Jun 26 03:37:26 UTC 2021
Record UNII
7QGN8QXG7I
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PRX-03140
Common Name English
4-HYDROXY-7-ISOPROPYL-6-OXO-N-(3-(1-PIPERIDINYL)PROPYL)-6,7-DIHYDROTHIENO(2,3-B)PYRIDINE-5-CARBOXAMIDE
Systematic Name English
Code System Code Type Description
CAS
869493-21-0
Created by admin on Sat Jun 26 03:37:26 UTC 2021 , Edited by admin on Sat Jun 26 03:37:26 UTC 2021
PRIMARY
PUBCHEM
54677674
Created by admin on Sat Jun 26 03:37:26 UTC 2021 , Edited by admin on Sat Jun 26 03:37:26 UTC 2021
PRIMARY
WIKIPEDIA
PRX-03140
Created by admin on Sat Jun 26 03:37:26 UTC 2021 , Edited by admin on Sat Jun 26 03:37:26 UTC 2021
PRIMARY
DRUG BANK
DB05596
Created by admin on Sat Jun 26 03:37:26 UTC 2021 , Edited by admin on Sat Jun 26 03:37:26 UTC 2021
PRIMARY
FDA UNII
7QGN8QXG7I
Created by admin on Sat Jun 26 03:37:26 UTC 2021 , Edited by admin on Sat Jun 26 03:37:26 UTC 2021
PRIMARY
EPA CompTox
869493-21-0
Created by admin on Sat Jun 26 03:37:26 UTC 2021 , Edited by admin on Sat Jun 26 03:37:26 UTC 2021
PRIMARY
Related Record Type Details
TARGET->PARTIAL AGONIST
Related Record Type Details
ACTIVE MOIETY