PRX-03140

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H27N3O3S
Molecular Weight	377.501
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)N1C2=C(C=CS2)C(O)=C(C(=O)NCCCN3CCCCC3)C1=O

InChI

InChIKey=SCHKZZSVELPJKU-UHFFFAOYSA-N

InChI=1S/C19H27N3O3S/c1-13(2)22-18(25)15(16(23)14-7-12-26-19(14)22)17(24)20-8-6-11-21-9-4-3-5-10-21/h7,12-13,23H,3-6,8-11H2,1-2H3,(H,20,24)

HIDE SMILES / InChI

Molecular Formula	C19H27N3O3S
Molecular Weight	377.501
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/22408061 | https://www.ncbi.nlm.nih.gov/pubmed/21392515 | https://www.ncbi.nlm.nih.gov/pubmed/30108781

PRX-03140 is a partial agonist of the 5-HT4 receptor that is being developed by EPIX Pharmaceuticals for Alzheimer's disease. In vitro shows potent binding to 5-HT4 receptor and increased cAMP production in human embryonic kidney-293 cells expressing recombinant rat 5-HT(4) receptors. In the clinical trial, PRX-03140 was associated with a statistically significant improvement in the Alzheimer’s Disease Assessment Scale.

Originator

Approval Year

PubMed

Title	Date	PubMed
VRX-03011, a novel 5-HT4 agonist, enhances memory and hippocampal acetylcholine efflux.	2007 Sep	17692343

Patents

Sample Use Guides

In Vivo Use Guide

50 mg PRX-03140 capsules once daily for 2 weeks. After 2 weeks, the dose will increase to 100mg PRX-03140 once daily for 10 weeks.

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Sat Dec 16 05:49:06 GMT 2023` Edited by `admin` on `Sat Dec 16 05:49:06 GMT 2023`
Record UNII	7QGN8QXG7I
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PRX-03140

Common Name

English

4-HYDROXY-7-ISOPROPYL-6-OXO-N-(3-(1-PIPERIDINYL)PROPYL)-6,7-DIHYDROTHIENO(2,3-B)PYRIDINE-5-CARBOXAMIDE

Systematic Name

English

Code System Code Type Description

CAS

869493-21-0