MEDROXALOL

Details

Stereochemistry	MIXED
Molecular Formula	C20H24N2O5
Molecular Weight	372.415
Optical Activity	UNSPECIFIED
Defined Stereocenters	0 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(CCC1=CC2=C(OCO2)C=C1)NCC(O)C3=CC(C(N)=O)=C(O)C=C3

InChI

InChIKey=MPQWSYJGFLADEW-UHFFFAOYSA-N

InChI=1S/C20H24N2O5/c1-12(2-3-13-4-7-18-19(8-13)27-11-26-18)22-10-17(24)14-5-6-16(23)15(9-14)20(21)25/h4-9,12,17,22-24H,2-3,10-11H2,1H3,(H2,21,25)

HIDE SMILES / InChI

Molecular Formula	C20H24N2O5
Molecular Weight	372.415
Charge	0
Count

Stereochemistry	MIXED
Additional Stereochemistry	No
Defined Stereocenters	0 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6166802 | https://www.ncbi.nlm.nih.gov/pubmed/6144408 | https://www.ncbi.nlm.nih.gov/pubmed/6111723

Medroxalol is a competitive antagonist at alpha1-adrenergic receptors and beta1-adrenergic receptors. Medroxalol also an agonist at beta2-adrenergic receptors. Medroxalol exerts antihypertensive and vasodilating effects. It was concluded that the principal action of medroxalol was to produce a fall in blood pressure by decreasing peripheral vascular resistance more than cardiac output.

Approval Year

PubMed

Title	Date	PubMed
Antihypertensive and vasodilating effects of acute medroxalol, a new beta-blocker with beta-2-adrenergic receptor stimulation.	1986-07-01	3795977
Analysis of the hypotensive effects of medroxalol and its enantiomers, MDL 17,330A and MDL 17,331A.	1984	6144408
Cardiovascular properties of medroxalol, a new antihypertensive drug.	1981-03-01	6166802
Antihypertensive and adrenergic receptor blocking properties of the enantiomers of medroxalol.	1980-12-22	6111723

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:52:11 GMT 2025` Edited by `admin` on `Mon Mar 31 17:52:11 GMT 2025`
Record UNII	7PX96289JA
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MEDROXALOL

Official Name

English

RMI 81,968

Preferred Name

English

MEDROXALOL [USAN]

Common Name

English

Medroxalol [WHO-DD]

Common Name

English

medroxalol [INN]

Common Name

English

5-[1-Hydroxy-2-[[1-methyl-3-[3,4-(methylenedioxy)phenyl]propyl]amino]ethyl]salicylamide

Systematic Name

English

RMI-81,968

Common Name

English

RMI-81968

Code

English

RMI 81968

Code

English

BENZAMIDE, 5-(2-((3-(1,3-BENZODIOXOL-5-YL)-1-METHYLPROPYL)AMINO)-1-HYDROXYETHYL)-2-HYDROXY-

Systematic Name

English

Code System Code Type Description

CAS

56290-94-9