MEDROXALOL

Details

Stereochemistry	MIXED
Molecular Formula	C20H24N2O5
Molecular Weight	372.415
Optical Activity	UNSPECIFIED
Defined Stereocenters	0 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(CCC1=CC=C2OCOC2=C1)NCC(O)C3=CC=C(O)C(=C3)C(N)=O

InChI

InChIKey=MPQWSYJGFLADEW-UHFFFAOYSA-N

InChI=1S/C20H24N2O5/c1-12(2-3-13-4-7-18-19(8-13)27-11-26-18)22-10-17(24)14-5-6-16(23)15(9-14)20(21)25/h4-9,12,17,22-24H,2-3,10-11H2,1H3,(H2,21,25)

HIDE SMILES / InChI

Molecular Formula	C20H24N2O5
Molecular Weight	372.415
Charge	0
Count

Stereochemistry	MIXED
Additional Stereochemistry	No
Defined Stereocenters	0 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6166802 | https://www.ncbi.nlm.nih.gov/pubmed/6144408 | https://www.ncbi.nlm.nih.gov/pubmed/6111723

Medroxalol is a competitive antagonist at alpha1-adrenergic receptors and beta1-adrenergic receptors. Medroxalol also an agonist at beta2-adrenergic receptors. Medroxalol exerts antihypertensive and vasodilating effects. It was concluded that the principal action of medroxalol was to produce a fall in blood pressure by decreasing peripheral vascular resistance more than cardiac output.

Approval Year

PubMed

Title	Date	PubMed
Antihypertensive and adrenergic receptor blocking properties of the enantiomers of medroxalol.	1980 Dec 22-29	6111723
Cardiovascular properties of medroxalol, a new antihypertensive drug.	1981 Mar-Apr	6166802
Analysis of the hypotensive effects of medroxalol and its enantiomers, MDL 17,330A and MDL 17,331A.	1984	6144408
Antihypertensive and vasodilating effects of acute medroxalol, a new beta-blocker with beta-2-adrenergic receptor stimulation.	1986 Jul-Sep	3795977

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:16:03 GMT 2023` Edited by `admin` on `Fri Dec 15 15:16:03 GMT 2023`
Record UNII	7PX96289JA
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MEDROXALOL

Official Name

English

MEDROXALOL [USAN]

Common Name

English

Medroxalol [WHO-DD]

Common Name

English

medroxalol [INN]

Common Name

English

5-[1-Hydroxy-2-[[1-methyl-3-[3,4-(methylenedioxy)phenyl]propyl]amino]ethyl]salicylamide

Systematic Name

English

RMI-81,968

Common Name

English

RMI-81968

Code

English

RMI 81,968

Code

English

RMI 81968

Code

English

BENZAMIDE, 5-(2-((3-(1,3-BENZODIOXOL-5-YL)-1-METHYLPROPYL)AMINO)-1-HYDROXYETHYL)-2-HYDROXY-

Systematic Name

English

Code System Code Type Description

CAS

56290-94-9