EMICIZUMAB

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Sat Dec 16 11:19:19 GMT 2023` Edited by `admin` on `Sat Dec 16 11:19:19 GMT 2023`
Protein Type	BISPECIFIC ANTIBODY
Protein Sub Type	IGG4
Sequence Origin	HUMAN-RATTUS DISULFIDE WITH HUMAN-MUS MUSCULUS-RATTUS
Sequence Type	COMPLETE
Record UNII	7NL2E3F6K3
Record Status	`Validated (UNII)`
Record Version

Download

Related Record	Type

Name

Type

Language

EMICIZUMAB

Official Name

English

Emicizumab [WHO-DD]

Common Name

English

EMICIZUMAB [MI]

Common Name

English

emicizumab [INN]

Common Name

English

EMICIZUMAB [JAN]

Common Name

English

EMICIZUMAB [USAN]

Common Name

English

IMMUNOGLOBULIN G4-KAPPA, BISPECIFIC, ANTI-(HOMO SAPIENS F9A (ACTIVATED COAGULATION FACTOR F9, ACTIVATED COAGULATION FACTOR IX) AND ANTI-(HOMO SAPIENS F10 (COAGULATION FACTOR 10, COAGULATION FACTOR X)), HUMANIZED MONOCLONAL ANTIBODY

Common Name

English

Classification Tree Code System Code

WHO-ATC

B02BX06

Created by admin on Sat Dec 16 11:19:19 GMT 2023 , Edited by admin on Sat Dec 16 11:19:19 GMT 2023

FDA ORPHAN DRUG

416913

Created by admin on Sat Dec 16 11:19:19 GMT 2023 , Edited by admin on Sat Dec 16 11:19:19 GMT 2023

Code System Code Type Description

DRUG CENTRAL

5268

Created by admin on Sat Dec 16 11:19:19 GMT 2023 , Edited by admin on Sat Dec 16 11:19:19 GMT 2023

PRIMARY

CAS

1610943-06-0

Created by admin on Sat Dec 16 11:19:19 GMT 2023 , Edited by admin on Sat Dec 16 11:19:19 GMT 2023

PRIMARY

SMS_ID

100000169091

Created by admin on Sat Dec 16 11:19:19 GMT 2023 , Edited by admin on Sat Dec 16 11:19:19 GMT 2023

PRIMARY

INN

10115

Created by admin on Sat Dec 16 11:19:19 GMT 2023 , Edited by admin on Sat Dec 16 11:19:19 GMT 2023

PRIMARY

DAILYMED

7NL2E3F6K3

Created by admin on Sat Dec 16 11:19:19 GMT 2023 , Edited by admin on Sat Dec 16 11:19:19 GMT 2023

PRIMARY

USAN

EF-03

Created by admin on Sat Dec 16 11:19:19 GMT 2023 , Edited by admin on Sat Dec 16 11:19:19 GMT 2023

PRIMARY

WIKIPEDIA

Emicizumab

Created by admin on Sat Dec 16 11:19:19 GMT 2023 , Edited by admin on Sat Dec 16 11:19:19 GMT 2023

PRIMARY

LACTMED

Emicizumab

Created by admin on Sat Dec 16 11:19:19 GMT 2023 , Edited by admin on Sat Dec 16 11:19:19 GMT 2023

PRIMARY

MERCK INDEX

m12056

Created by admin on Sat Dec 16 11:19:19 GMT 2023 , Edited by admin on Sat Dec 16 11:19:19 GMT 2023

PRIMARY

DRUG BANK

DB13923

Created by admin on Sat Dec 16 11:19:19 GMT 2023 , Edited by admin on Sat Dec 16 11:19:19 GMT 2023

PRIMARY

EVMPD

SUB182706

Created by admin on Sat Dec 16 11:19:19 GMT 2023 , Edited by admin on Sat Dec 16 11:19:19 GMT 2023

PRIMARY

FDA UNII

7NL2E3F6K3

Created by admin on Sat Dec 16 11:19:19 GMT 2023 , Edited by admin on Sat Dec 16 11:19:19 GMT 2023

PRIMARY

RXCUI

1989795

Created by admin on Sat Dec 16 11:19:19 GMT 2023 , Edited by admin on Sat Dec 16 11:19:19 GMT 2023

ALTERNATIVE

RXCUI

1989794

Created by admin on Sat Dec 16 11:19:19 GMT 2023 , Edited by admin on Sat Dec 16 11:19:19 GMT 2023

PRIMARY

NCI_THESAURUS

C159541

Created by admin on Sat Dec 16 11:19:19 GMT 2023 , Edited by admin on Sat Dec 16 11:19:19 GMT 2023

PRIMARY

From	To
1_22	1_96
1_150	1_206
1_264	1_324
1_370	1_428
2_22	2_96
2_146	2_202
2_260	2_320
2_366	2_424
3_23	3_88
3_134	3_194
4_23	4_88
4_134	4_194
1_137	3_214
2_133	4_214
1_229	2_225
1_232	2_228

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_300
N	2_296

Related Record Type Details


					0P94UQE6SY

COAGULATION FACTOR X HUMAN

TARGET -> ACTIVATOR

Amount:


					839MOZ74GK

ANTIHEMOPHILIC FACTOR HUMAN

TARGET->ENZYME REPLACEMENT

Comments:

Emicizumab binds to both the activated coagulation factor IX and to factor X, mediating the activation of the latter. Mimics the function of coagulation factor VIII, which is missing in haemophilia A patients.

Amount:

EMICIZUMAB-KXWH

INNOVATOR->PARENT

Amount:

EMICIZUMAB-KXWH

BIOSIMILAR -> PARENT


					6U90Y1795T

COAGULATION FACTOR IX HUMAN

TARGET -> ACTIVATOR

Amount:

EMICIZUMAB-KXWH

SUB_CONCEPT->SUBSTANCE

Amount:

Related Record Type Details


					7NL2E3F6K3

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Volume of Distribution	PHARMACOKINETIC

Biological Half-life	PHARMACOKINETIC

Molecular Formula	CHEMICAL