U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Sat Dec 16 11:19:19 GMT 2023
Edited
by admin
on Sat Dec 16 11:19:19 GMT 2023
Protein Type BISPECIFIC ANTIBODY
Protein Sub Type IGG4
Sequence Origin HUMAN-RATTUS DISULFIDE WITH HUMAN-MUS MUSCULUS-RATTUS
Sequence Type COMPLETE
Record UNII
7NL2E3F6K3
Record Status Validated (UNII)
Record Version
  • Download
Related Record Type
Name Type Language
EMICIZUMAB
INN   USAN   WHO-DD  
INN   USAN  
Official Name English
Emicizumab [WHO-DD]
Common Name English
EMICIZUMAB [MI]
Common Name English
emicizumab [INN]
Common Name English
EMICIZUMAB [JAN]
Common Name English
EMICIZUMAB [USAN]
Common Name English
IMMUNOGLOBULIN G4-KAPPA, BISPECIFIC, ANTI-(HOMO SAPIENS F9A (ACTIVATED COAGULATION FACTOR F9, ACTIVATED COAGULATION FACTOR IX) AND ANTI-(HOMO SAPIENS F10 (COAGULATION FACTOR 10, COAGULATION FACTOR X)), HUMANIZED MONOCLONAL ANTIBODY
Common Name English
Classification Tree Code System Code
WHO-ATC B02BX06
Created by admin on Sat Dec 16 11:19:19 GMT 2023 , Edited by admin on Sat Dec 16 11:19:19 GMT 2023
FDA ORPHAN DRUG 416913
Created by admin on Sat Dec 16 11:19:19 GMT 2023 , Edited by admin on Sat Dec 16 11:19:19 GMT 2023
Code System Code Type Description
DRUG CENTRAL
5268
Created by admin on Sat Dec 16 11:19:19 GMT 2023 , Edited by admin on Sat Dec 16 11:19:19 GMT 2023
PRIMARY
CAS
1610943-06-0
Created by admin on Sat Dec 16 11:19:19 GMT 2023 , Edited by admin on Sat Dec 16 11:19:19 GMT 2023
PRIMARY
SMS_ID
100000169091
Created by admin on Sat Dec 16 11:19:19 GMT 2023 , Edited by admin on Sat Dec 16 11:19:19 GMT 2023
PRIMARY
INN
10115
Created by admin on Sat Dec 16 11:19:19 GMT 2023 , Edited by admin on Sat Dec 16 11:19:19 GMT 2023
PRIMARY
DAILYMED
7NL2E3F6K3
Created by admin on Sat Dec 16 11:19:19 GMT 2023 , Edited by admin on Sat Dec 16 11:19:19 GMT 2023
PRIMARY
USAN
EF-03
Created by admin on Sat Dec 16 11:19:19 GMT 2023 , Edited by admin on Sat Dec 16 11:19:19 GMT 2023
PRIMARY
WIKIPEDIA
Emicizumab
Created by admin on Sat Dec 16 11:19:19 GMT 2023 , Edited by admin on Sat Dec 16 11:19:19 GMT 2023
PRIMARY
LACTMED
Emicizumab
Created by admin on Sat Dec 16 11:19:19 GMT 2023 , Edited by admin on Sat Dec 16 11:19:19 GMT 2023
PRIMARY
MERCK INDEX
m12056
Created by admin on Sat Dec 16 11:19:19 GMT 2023 , Edited by admin on Sat Dec 16 11:19:19 GMT 2023
PRIMARY
DRUG BANK
DB13923
Created by admin on Sat Dec 16 11:19:19 GMT 2023 , Edited by admin on Sat Dec 16 11:19:19 GMT 2023
PRIMARY
EVMPD
SUB182706
Created by admin on Sat Dec 16 11:19:19 GMT 2023 , Edited by admin on Sat Dec 16 11:19:19 GMT 2023
PRIMARY
FDA UNII
7NL2E3F6K3
Created by admin on Sat Dec 16 11:19:19 GMT 2023 , Edited by admin on Sat Dec 16 11:19:19 GMT 2023
PRIMARY
RXCUI
1989795
Created by admin on Sat Dec 16 11:19:19 GMT 2023 , Edited by admin on Sat Dec 16 11:19:19 GMT 2023
ALTERNATIVE
RXCUI
1989794
Created by admin on Sat Dec 16 11:19:19 GMT 2023 , Edited by admin on Sat Dec 16 11:19:19 GMT 2023
PRIMARY
NCI_THESAURUS
C159541
Created by admin on Sat Dec 16 11:19:19 GMT 2023 , Edited by admin on Sat Dec 16 11:19:19 GMT 2023
PRIMARY
From To
1_22 1_96
1_150 1_206
1_264 1_324
1_370 1_428
2_22 2_96
2_146 2_202
2_260 2_320
2_366 2_424
3_23 3_88
3_134 3_194
4_23 4_88
4_134 4_194
1_137 3_214
2_133 4_214
1_229 2_225
1_232 2_228
Glycosylation Type MAMMALIAN
Glycosylation Link Type Site
N 1_300
N 2_296
Related Record Type Details
TARGET -> ACTIVATOR
TARGET->ENZYME REPLACEMENT
Emicizumab binds to both the activated coagulation factor IX and to factor X, mediating the activation of the latter. Mimics the function of coagulation factor VIII, which is missing in haemophilia A patients.
INNOVATOR->PARENT
BIOSIMILAR -> PARENT
TARGET -> ACTIVATOR
SUB_CONCEPT->SUBSTANCE
Related Record Type Details
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL
Volume of Distribution PHARMACOKINETIC
Biological Half-life PHARMACOKINETIC
Molecular Formula CHEMICAL