Details
Stereochemistry | ACHIRAL |
Molecular Formula | O4S |
Molecular Weight | 96.063 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | -2 |
SHOW SMILES / InChI
SMILES
[O-]S([O-])(=O)=O
InChI
InChIKey=QAOWNCQODCNURD-UHFFFAOYSA-L
InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2
Molecular Formula | H2O4S |
Molecular Weight | 98.078 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
SULFATE (as sodium sulfate, potassium sulfate, and magnesium sulfate) is a component of SUPREP Bowel Prep Kit. It is an osmotic laxative indicated for cleansing of the colon in preparation for colonoscopy in adults. Sulfate salts provide sulfate anions, which are poorly absorbed. The osmotic effect of unabsorbed sulfate anions and the associated cations causes water to be retained within the gastrointestinal tract. SUPREP Bowel Prep Kit, when ingested with a large volume of water, produces copious watery diarrhea.
Approval Year
PubMed
Title | Date | PubMed |
---|---|---|
Management of autonomic dysfunction in severe tetanus: the use of magnesium sulphate and clonidine. | 1990 |
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Sodium dodecyl sulphate electrophoresis of urinary proteins. | 1991 Sep 13 |
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Patterns of sulphation in heparan sulphate: polymorphism based on a common structural theme. | 1992 Apr |
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Heparan sulphate in the binding and activation of basic fibroblast growth factor. | 1992 Dec |
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Death by tanning--a case of fatal basic chromium sulphate poisoning. | 1994 |
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Keratan sulphate--a 'reserve' polysaccharide? | 1994 Apr |
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Renal and small intestinal sodium-dependent symporters of phosphate and sulphate. | 1994 Nov |
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Dextran sulphate induces a PKC and actin independent internalisation of CD4. | 1994 Sep |
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The osmotic and intrinsic mechanisms of the pharmacological laxative action of oral high doses of magnesium sulphate. Importance of the release of digestive polypeptides and nitric oxide. | 1996 Jun |
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Two selectins converge on sulphate. Leukocyte adhesion. | 1996 Mar 1 |
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The role of stromal cell heparan sulphate in regulating haemopoiesis. | 1996 May |
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Dehydroepiandrosterone, dehydroepiandrosterone sulphate and cardiovascular disease. | 1996 Sep |
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Heparan sulphate. | 1997 May |
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Structure-activity relationship of heparan sulphate. | 1997 Nov |
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Heparan sulphate proteoglycan and wound healing in skin. | 1997 Nov |
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Dermatan sulphate as an antithrombotic drug. | 2002 Sep-Dec |
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Magnesium sulphate versus phenytoin for eclampsia. | 2003 |
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Magnesium sulphate versus diazepam for eclampsia. | 2003 |
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Magnesium sulphate and other anticonvulsants for women with pre-eclampsia. | 2003 |
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Heparan sulphate proteoglycans in Alzheimer's disease and amyloid-related disorders. | 2003 Aug |
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Are low dehydroepiandrosterone sulphate levels predictive for cardiovascular diseases? A review of prospective and retrospective studies. | 2003 Oct |
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Characterization of the Herpesvirus saimiri Orf51 protein. | 2004 Aug 15 |
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The SLC13 gene family of sodium sulphate/carboxylate cotransporters. | 2004 Feb |
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Chondroitin sulphate proteoglycans: preventing plasticity or protecting the CNS? | 2004 Jan |
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Molecular recognition by LARGE is essential for expression of functional dystroglycan. | 2004 Jun 25 |
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[The extracellular matrix of the central nervous system: chondroitin sulphate type proteoglycans and neural repair]. | 2004 May 1-15 |
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Epidemiology of 377 patients with chemical burns in Guangdong province. | 2004 Sep |
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Biotechnological engineering of heparin/heparan sulphate: a novel area of multi-target drug discovery. | 2005 |
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Evidence and practice: the magnesium sulphate story. | 2005 Feb |
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A meta-analysis on intravenous magnesium sulphate for treating acute asthma. | 2005 Jan |
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Heparan sulphate proteoglycans: the sweet side of development. | 2005 Jul |
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A review of the role for magnesium sulphate in preterm labour. | 2005 Mar |
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Chondroitin sulphate: antioxidant properties and beneficial effects. | 2006 Dec |
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Heparan sulphate proteoglycans and viral vectors : ally or foe? | 2006 Feb |
|
[Magnesium sulphate for the management of preeclampsia]. | 2006 Jan |
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Interferon and heparan sulphate. | 2006 Jun |
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Heparin/heparan sulphate binding in the TGF-beta cytokine superfamily. | 2006 Jun |
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Heparan sulphate requirement in platelet-derived growth factor B-mediated pericyte recruitment. | 2006 Jun |
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The role of heparan sulphate proteoglycans in angiogenesis. | 2006 Jun |
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Insights into the role of heparan sulphate in fibroblast growth factor signalling. | 2006 Jun |
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Multiprotein signalling complexes: regional assembly on heparan sulphate. | 2006 Jun |
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Signalling by HGF/SF and Met: the role of heparan sulphate co-receptors. | 2006 Jun |
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Dietary acidification enhances phosphorus digestibility but decreases H+/K+-ATPase expression in rainbow trout. | 2006 Oct |
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The role of heparan sulphate in inflammation. | 2006 Sep |
|
Overcoming chondroitin sulphate proteoglycan inhibition of axon growth in the injured brain: lessons from chondroitinase ABC. | 2007 |
|
[Therapy of osteoarthritis crystalline glucosamine sulphate/a review of the clinical effcacy]. | 2007 |
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Heparan sulphate proteoglycans fine-tune mammalian physiology. | 2007 Apr 26 |
|
Magnesium sulphate for women at risk of preterm birth for neuroprotection of the fetus. | 2007 Jul 18 |
|
Evaluation of formocresol versus ferric sulphate primary molar pulpotomy: a systematic review and meta-analysis. | 2007 Oct |
|
Cholesterol sulfate as a potential inhibitor of hepatitis C virus NS3 helicase. | 2014 Apr |
Patents
Sample Use Guides
Split-Dose (2-Day) Regimen:
The evening before colonoscopy: dilute one bottle with water to a total volume of 16 oz. (up to the fill line) and drink the entire amount. Drink 32 ounces of water over the next hour.
Next morning: repeat both steps using the second bottle. Complete preparation at least 2 hours before colonoscopy or as directed by a physician.
Route of Administration:
Oral
Substance Class |
Chemical
Created
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Record UNII |
7IS9N8KPMG
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Record Status |
Validated (UNII)
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C597
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39576-4
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143 (Number of products:47)
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26889-6
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43754-1
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N0000175811
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17666-9
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DB14546
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SULFATE
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PARENT -> IMPURITY |
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EP
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EP
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PARENT -> IMPURITY |
EP
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PARENT -> IMPURITY |
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ACTIVE MOIETY |