SULFATE ION

First marketed in 1921

Details

Stereochemistry	ACHIRAL
Molecular Formula	O4S
Molecular Weight	96.063
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	-2

SHOW SMILES / InChI

Structure Search

SMILES

[O-]S([O-])(=O)=O

InChI

InChIKey=QAOWNCQODCNURD-UHFFFAOYSA-L

InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2

HIDE SMILES / InChI

Molecular Formula	H2O4S
Molecular Weight	98.078
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/022372s004lbledt.pdf | https://www.webmd.com/drugs/2/drug-154631/suprep-bowel-prep-kit-oral/details

SULFATE (as sodium sulfate, potassium sulfate, and magnesium sulfate) is a component of SUPREP Bowel Prep Kit. It is an osmotic laxative indicated for cleansing of the colon in preparation for colonoscopy in adults. Sulfate salts provide sulfate anions, which are poorly absorbed. The osmotic effect of unabsorbed sulfate anions and the associated cations causes water to be retained within the gastrointestinal tract. SUPREP Bowel Prep Kit, when ingested with a large volume of water, produces copious watery diarrhea.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Bowel Cleanser 8 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/022372s004lbledt.pdf	Palliative		Approved 8583	SUPREP Bowel Prep Kit Approved Use SUPREP Bowel Prep Kit is an osmotic laxative indicated for cleansing of the colon in preparation for colonoscopy in adults. Launch Date 2010

PubMed

Title	Date	PubMed
Management of autonomic dysfunction in severe tetanus: the use of magnesium sulphate and clonidine.	1990	2094230
Sodium dodecyl sulphate electrophoresis of urinary proteins.	1991 Sep 13	1939488
Patterns of sulphation in heparan sulphate: polymorphism based on a common structural theme.	1992 Apr	1516727
Heparan sulphate in the binding and activation of basic fibroblast growth factor.	1992 Dec	1472758
Keratan sulphate--a 'reserve' polysaccharide?	1994 Apr	8038262
Renal and small intestinal sodium-dependent symporters of phosphate and sulphate.	1994 Nov	7823020
The osmotic and intrinsic mechanisms of the pharmacological laxative action of oral high doses of magnesium sulphate. Importance of the release of digestive polypeptides and nitric oxide.	1996 Jun	8878010
Heparan sulphate.	1997 May	9251237
Structure-activity relationship of heparan sulphate.	1997 Nov	9449976
Heparan sulphate proteoglycan and wound healing in skin.	1997 Nov	9422978
Dopamine sulphate: an enigma resolved.	1999 Apr	10386253
The use of magnesium sulphate in the intensive care management of an Asian patient with tetanus.	1999 Jul	10561778
Magnesium sulphate versus diazepam for eclampsia.	2000	10796145
Specificities of heparan sulphate proteoglycans in developmental processes.	2000 Apr 13	10783877
Magnesium sulphate versus lytic cocktail for eclampsia.	2001	11279786
Magnesium sulphate versus phenytoin for eclampsia.	2003	14583911
Magnesium sulphate and other anticonvulsants for women with pre-eclampsia.	2003	12804383
[The extracellular matrix of the central nervous system: chondroitin sulphate type proteoglycans and neural repair].	2004 May 1-15	15152354
Heparan sulphate proteoglycans and viral vectors : ally or foe?	2006 Feb	16475944
[Magnesium sulphate for the management of preeclampsia].	2006 Jan	16406662
Heparin/heparan sulphate binding in the TGF-beta cytokine superfamily.	2006 Jun	16709187
Heparan sulphate requirement in platelet-derived growth factor B-mediated pericyte recruitment.	2006 Jun	16709185
Insights into the role of heparan sulphate in fibroblast growth factor signalling.	2006 Jun	16709182
Signalling by HGF/SF and Met: the role of heparan sulphate co-receptors.	2006 Jun	16709175
Dietary acidification enhances phosphorus digestibility but decreases H+/K+-ATPase expression in rainbow trout.	2006 Oct	16985189
The role of heparan sulphate in inflammation.	2006 Sep	16917509
Evaluation of formocresol versus ferric sulphate primary molar pulpotomy: a systematic review and meta-analysis.	2007 Oct	17714467
Cholesterol sulfate as a potential inhibitor of hepatitis C virus NS3 helicase.	2014 Apr	23432541

Patents

Sample Use Guides

In Vivo Use Guide

Split-Dose (2-Day) Regimen: The evening before colonoscopy: dilute one bottle with water to a total volume of 16 oz. (up to the fill line) and drink the entire amount. Drink 32 ounces of water over the next hour. Next morning: repeat both steps using the second bottle. Complete preparation at least 2 hours before colonoscopy or as directed by a physician.

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:20:26 GMT 2025` Edited by `admin` on `Mon Mar 31 18:20:26 GMT 2025`
Record UNII	7IS9N8KPMG
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SULFATE

Preferred Name

English

SULFATE ION

Common Name

English

SULFATE(2-)

Common Name

English

SULPHATE

Systematic Name

English

SULPHATE ION

Common Name

English

SULPHATE(2-)

Common Name

English

SULFATE [VANDF]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C597