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Description

Ziconotide (PRIALT; SNX-111) is a neuroactive peptide, which was approved by FDA in 2004 for the management of severe chronic pain in adult patients for whom intrathecal therapy is warranted, and who are intolerant of or refractory to other treatment, such as systemic analgesics, adjunctive therapies, or intrathecal morphine. Ziconotide acts as a selective N-type voltage-gated calcium channel blocker, which leads to a blockade of excitatory neurotransmitter release from the primary afferent nerve terminals.

CNS Activity

Approval Year

2004
210
Targets

Targets

Primary TargetPharmacologyConditionPotency
Blocker
537
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8429
PRIALT

Approved Use

PRIALT (ziconotide) solution, intrathecal infusion is an N-type calcium channel antagonist indicated for the management of severe chronic pain in patients for whom intrathecal therapy is warranted, and who are intolerant of or refractory to other treatment, such as systemic analgesics, adjunctive therapies, or intrathecal morphine.

Launch Date

2004
PubMed

PubMed

TitleDatePubMed
Neuronal calcium channel antagonists. Discrimination between calcium channel subtypes using omega-conotoxin from Conus magus venom.
1987 Apr 21
Novel omega-conotoxins from Conus catus discriminate among neuronal calcium channel subtypes.
2000 Nov 10
Identification and characterization of novel human Ca(v)2.2 (alpha 1B) calcium channel variants lacking the synaptic protein interaction site.
2002 Jan 1
Ziconotide: neuronal calcium channel blocker for treating severe chronic pain.
2004 Dec
Pharmacological characterization of recombinant N-type calcium channel (Cav2.2) mediated calcium mobilization using FLIPR.
2006 Sep 14
Mechanisms of conotoxin inhibition of N-type (Ca(v)2.2) calcium channels.
2013 Jul

Sample Use Guides

In Vivo Use Guide
PRIALT (ziconotide) solution is intended for administration by or under the direction of a physician experienced in the technique of intrathecal administration and who is familiar with the drug and device labeling. PRIALT may be used for therapy undiluted (25 mcg/mL in 20 mL vial) or diluted (100 mcg/mL in 1 or 5 mL vials). The 100 mcg/mL formulation may be administered undiluted once an appropriate dose has been established.
Route of Administration: Other
Substance Class Protein
Created
by admin
on Sat Dec 16 00:59:59 GMT 2023
Edited
by admin
on Sat Dec 16 00:59:59 GMT 2023
Protein Sub Type
Sequence Type COMPLETE
Record UNII
7I64C51O16
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ZICONOTIDE
EMA EPAR   HSDB   INN   MART.   MI   ORANGE BOOK   USAN   VANDF   WHO-DD  
USAN   INN  
Official Name English
ZICONOTIDE [USAN]
Common Name English
ZICONOTIDE [MI]
Common Name English
ZICONOTIDE [VANDF]
Common Name English
ziconotide [INN]
Common Name English
ZICONOTIDE [EMA EPAR]
Common Name English
ZICONOTIDE [ORANGE BOOK]
Common Name English
Ziconotide [WHO-DD]
Common Name English
ZICONOTIDE [MART.]
Common Name English
SNX-111
Code English
CYS-LYS-GLY-LYS-GLY-ALA-LYS-CYS-SER-ARG-LEU-MET-TYR-ASP-CYS-CYS-THR-GLY-SER-CYS-ARG-SER-GLY-LYS-CYS-NH2
Common Name English
.OMEGA.-CONOTOXIN M VIIA
Common Name English
ZICONOTIDE [HSDB]
Common Name English
Classification Tree Code System Code
NDF-RT N0000175697
Created by admin on Sat Dec 16 00:59:59 GMT 2023 , Edited by admin on Sat Dec 16 00:59:59 GMT 2023
EMA ASSESSMENT REPORTS PRIALT (AUTHORIZED: PAIN)
Created by admin on Sat Dec 16 00:59:59 GMT 2023 , Edited by admin on Sat Dec 16 00:59:59 GMT 2023
WHO-VATC QN02BG08
Created by admin on Sat Dec 16 00:59:59 GMT 2023 , Edited by admin on Sat Dec 16 00:59:59 GMT 2023
WHO-ATC N02BG08
Created by admin on Sat Dec 16 00:59:59 GMT 2023 , Edited by admin on Sat Dec 16 00:59:59 GMT 2023
NDF-RT N0000020069
Created by admin on Sat Dec 16 00:59:59 GMT 2023 , Edited by admin on Sat Dec 16 00:59:59 GMT 2023
NCI_THESAURUS C2198
Created by admin on Sat Dec 16 00:59:59 GMT 2023 , Edited by admin on Sat Dec 16 00:59:59 GMT 2023
Code System Code Type Description
SMS_ID
100000088019
Created by admin on Sat Dec 16 00:59:59 GMT 2023 , Edited by admin on Sat Dec 16 00:59:59 GMT 2023
PRIMARY
DAILYMED
7I64C51O16
Created by admin on Sat Dec 16 00:59:59 GMT 2023 , Edited by admin on Sat Dec 16 00:59:59 GMT 2023
PRIMARY
MERCK INDEX
m11591
Created by admin on Sat Dec 16 00:59:59 GMT 2023 , Edited by admin on Sat Dec 16 00:59:59 GMT 2023
PRIMARY Merck Index
CHEBI
142406
Created by admin on Sat Dec 16 00:59:59 GMT 2023 , Edited by admin on Sat Dec 16 00:59:59 GMT 2023
PRIMARY
DRUG BANK
DB06283
Created by admin on Sat Dec 16 00:59:59 GMT 2023 , Edited by admin on Sat Dec 16 00:59:59 GMT 2023
PRIMARY
ChEMBL
CHEMBL2103752
Created by admin on Sat Dec 16 00:59:59 GMT 2023 , Edited by admin on Sat Dec 16 00:59:59 GMT 2023
PRIMARY
INN
7694
Created by admin on Sat Dec 16 00:59:59 GMT 2023 , Edited by admin on Sat Dec 16 00:59:59 GMT 2023
PRIMARY
WIKIPEDIA
ZICONOTIDE
Created by admin on Sat Dec 16 00:59:59 GMT 2023 , Edited by admin on Sat Dec 16 00:59:59 GMT 2023
PRIMARY
EVMPD
SUB00150MIG
Created by admin on Sat Dec 16 00:59:59 GMT 2023 , Edited by admin on Sat Dec 16 00:59:59 GMT 2023
PRIMARY
DRUG CENTRAL
2878
Created by admin on Sat Dec 16 00:59:59 GMT 2023 , Edited by admin on Sat Dec 16 00:59:59 GMT 2023
PRIMARY
MESH
C078452
Created by admin on Sat Dec 16 00:59:59 GMT 2023 , Edited by admin on Sat Dec 16 00:59:59 GMT 2023
PRIMARY
HSDB
7609
Created by admin on Sat Dec 16 00:59:59 GMT 2023 , Edited by admin on Sat Dec 16 00:59:59 GMT 2023
PRIMARY
EPA CompTox
DTXSID60883174
Created by admin on Sat Dec 16 00:59:59 GMT 2023 , Edited by admin on Sat Dec 16 00:59:59 GMT 2023
PRIMARY
FDA UNII
7I64C51O16
Created by admin on Sat Dec 16 00:59:59 GMT 2023 , Edited by admin on Sat Dec 16 00:59:59 GMT 2023
PRIMARY
CAS
107452-89-1
Created by admin on Sat Dec 16 00:59:59 GMT 2023 , Edited by admin on Sat Dec 16 00:59:59 GMT 2023
PRIMARY
USAN
JJ-10
Created by admin on Sat Dec 16 00:59:59 GMT 2023 , Edited by admin on Sat Dec 16 00:59:59 GMT 2023
PRIMARY
PUBCHEM
16135415
Created by admin on Sat Dec 16 00:59:59 GMT 2023 , Edited by admin on Sat Dec 16 00:59:59 GMT 2023
PRIMARY
NCI_THESAURUS
C1475
Created by admin on Sat Dec 16 00:59:59 GMT 2023 , Edited by admin on Sat Dec 16 00:59:59 GMT 2023
PRIMARY
RXCUI
68503
Created by admin on Sat Dec 16 00:59:59 GMT 2023 , Edited by admin on Sat Dec 16 00:59:59 GMT 2023
PRIMARY RxNorm
From To
1_1 1_16
1_8 1_20
1_15 1_25
Related Record Type Details
PLASMA PROTEIN FRACTION (HUMAN)
BINDER->LIGAND
BINDING
ZICONOTIDE ACETATE
SALT/SOLVATE -> PARENT
Related Record Type Details
ZICONOTIDE
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Biological Half-life PHARMACOKINETIC
Molecular Formula CHEMICAL
MOL_WEIGHT:SEQUENCE(CALCULATED) CHEMICAL
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
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