Tarcocimab Tedromer

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 23:27:38 GMT 2025` Edited by `admin` on `Tue Apr 01 23:27:38 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY CONJUGATE
Protein Sub Type	IGG1
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	7HW5CX6OD5
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Tarcocimab Tedromer

Official Name

English

KSI-301

Preferred Name

English

OG1953

Code

English

Tarcocimab tedromer [WHO-DD]

Common Name

English

TARCOCIMAB TEDROMER [USAN]

Common Name

English

Immunoglobulin G1 [240-alanine,241-alanine,243-alanine,449-cysteine], anti-(human vascular endothelial growth factor A) (human-Mus musculus monoclonal OG1950 g1-chain), disulfide with human-Mus musculus monoclonal OG1950 k-chain, (232?232'),(235?235')-bi

Common Name

English

OG-1953

Code

English

Immunoglobulin G1-kappa, anti-[Homo sapiens VEGFA (vascular endothelial growth factor A, VEGF-A, VEGF)], humanized monoclonal antibody, conjugated via a linker to a nonaantennary dendrimer with phosphorylcholine polymer end groups; gamma1 heavy chain hum

Common Name

English

tarcocimab tedromer [INN]

Common Name

English

Code System Code Type Description

SMS_ID

300000026353

Created by admin on Tue Apr 01 23:27:38 GMT 2025 , Edited by admin on Tue Apr 01 23:27:38 GMT 2025

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NCI_THESAURUS

C188530

Created by admin on Tue Apr 01 23:27:38 GMT 2025 , Edited by admin on Tue Apr 01 23:27:38 GMT 2025

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INN

11774

Created by admin on Tue Apr 01 23:27:38 GMT 2025 , Edited by admin on Tue Apr 01 23:27:38 GMT 2025

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CAS

2411896-53-0

Created by admin on Tue Apr 01 23:27:38 GMT 2025 , Edited by admin on Tue Apr 01 23:27:38 GMT 2025

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FDA UNII

7HW5CX6OD5

Created by admin on Tue Apr 01 23:27:38 GMT 2025 , Edited by admin on Tue Apr 01 23:27:38 GMT 2025

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USAN

KL-251

Created by admin on Tue Apr 01 23:27:38 GMT 2025 , Edited by admin on Tue Apr 01 23:27:38 GMT 2025

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From	To
1_22	1_96
1_449	2_22
2_96	2_150
2_206	4_134
2_235	2_267
1_150	1_206
2_327	2_373
2_431	2_449
3_23	3_88
3_194	3_214
4_23	4_88
1_226	3_134
1_232	2_226
1_235	2_232
1_267	1_327
1_373	1_431

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_303
N	2_303

Related Record Type Details


					NZN256ZSV8

HUMAN VASCULAR ENDOTHELIAL GROWTH FACTOR A

TARGET -> INHIBITOR

Amount:


					QNU3MX7NBY

PARENT -> CONJUGATE

Amount:

Related Record Type Details


					7HW5CX6OD5

Tarcocimab Tedromer

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_449] [2_449]			Amount:	Cysteinyl tedromer	UX31RFU342
AMINO ACID REMOVAL	[1_453] [2_453]	C-TERMINUS			LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER AVERAGE	CHEMICAL