YM-976

CCN1C(=O)N=C(C2=CC=CC(Cl)=C2)C3=CC=C(CC)N=C13

InChIKey=MNHXYNNKDDXKNP-UHFFFAOYSA-N

InChI=1S/C17H16ClN3O/c1-3-13-8-9-14-15(11-6-5-7-12(18)10-11)20-17(22)21(4-2)16(14)19-13/h5-10H,3-4H2,1-2H3

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Targets

Primary Target	Pharmacology	Condition	Potency
Phosphodiesterase 4 54 Target ID: CHEMBL2093863 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10991987	Inhibitor 8504		2.2 nM [IC50]

PubMed

Title	Date	PubMed
Relaxant effect of YM976, a novel phosphodiesterase 4 inhibitor, on bovine tracheal smooth muscle.	2003-05-30	12787831
A novel phosphodiesterase type 4 inhibitor, YM976 (4-(3-chlorophenyl)-1,7-diethylpyrido[2,3-d]pyrimidin-2(1H)-one), with little emetogenic activity.	2000-10	10991987

Patents

Substance Class	Chemical Created by `admin` on `Wed Apr 02 10:05:37 GMT 2025` Edited by `admin` on `Wed Apr 02 10:05:37 GMT 2025`
Record UNII	7GQT2M8W42
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

4-(3-CHLOROPHENYL)-1,7-DIETHYLPYRIDO(2,3-D)PYRIMIDIN-2(1H)-ONE

Preferred Name

English

YM-976

Common Name

English

PYRIDO(2,3-D)PYRIMIDIN-2(1H)-ONE, 4-(3-CHLOROPHENYL)-1,7-DIETHYL-

Systematic Name

English

Code System Code Type Description

FDA UNII

7GQT2M8W42