YM-976

CCN1C(=O)N=C(C2=CC(Cl)=CC=C2)C3=C1N=C(CC)C=C3

InChIKey=MNHXYNNKDDXKNP-UHFFFAOYSA-N

InChI=1S/C17H16ClN3O/c1-3-13-8-9-14-15(11-6-5-7-12(18)10-11)20-17(22)21(4-2)16(14)19-13/h5-10H,3-4H2,1-2H3

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Targets

Primary Target	Pharmacology	Condition	Potency
Phosphodiesterase 4 52 Target ID: CHEMBL2093863 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10991987	Inhibitor 8297		2.2 nM [IC50]

PubMed

Title	Date	PubMed
A novel phosphodiesterase type 4 inhibitor, YM976 (4-(3-chlorophenyl)-1,7-diethylpyrido[2,3-d]pyrimidin-2(1H)-one), with little emetogenic activity.	2000 Oct	10991987
Relaxant effect of YM976, a novel phosphodiesterase 4 inhibitor, on bovine tracheal smooth muscle.	2003 May 30	12787831

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 18:06:08 UTC 2023` Edited by `admin` on `Sat Dec 16 18:06:08 UTC 2023`
Record UNII	7GQT2M8W42
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

YM-976

Common Name

English

4-(3-CHLOROPHENYL)-1,7-DIETHYLPYRIDO(2,3-D)PYRIMIDIN-2(1H)-ONE

Systematic Name

English

PYRIDO(2,3-D)PYRIMIDIN-2(1H)-ONE, 4-(3-CHLOROPHENYL)-1,7-DIETHYL-

Systematic Name

English

Code System Code Type Description

FDA UNII

7GQT2M8W42