CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4A

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 16:28:01 GMT 2025` Edited by `admin` on `Tue Apr 01 16:28:01 GMT 2025`
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	651CFC5G66
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4A

Common Name

English

CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4A ISOFORM 1

Preferred Name

English

PDE4A ISOFORM 1

Common Name

English

PDE4A

Common Name

English

Code System Code Type Description

PHAROS

P27815

Created by admin on Tue Apr 01 16:28:01 GMT 2025 , Edited by admin on Tue Apr 01 16:28:01 GMT 2025

PRIMARY

FDA UNII

651CFC5G66

Created by admin on Tue Apr 01 16:28:01 GMT 2025 , Edited by admin on Tue Apr 01 16:28:01 GMT 2025

PRIMARY

UNIPROT

P27815

Created by admin on Tue Apr 01 16:28:01 GMT 2025 , Edited by admin on Tue Apr 01 16:28:01 GMT 2025

PRIMARY

Related Record Type Details


					651CFC5G66

CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4A

INHIBITOR -> TARGET

Comments:

PDE4

Interaction Type:

INHIBITOR

Qualification:

IC50

Amount:


					N48GH1UIR0

MK-0952

INHIBITOR -> TARGET

Qualification:

IC50

Amount:


					YOG0PR3Q8J

UK-500001

INHIBITOR -> TARGET


					550671J24D

AWD-12-281

INHIBITOR -> TARGET


					F08MQ6CZCS

Roflumilast N-oxide

INHIBITOR -> TARGET

Qualification:

IC50

Amount:


					JH1CX8SG5V

ORISMILAST

INHIBITOR -> TARGET


					263T0E9RR9

DYPHYLLINE

INHIBITOR -> TARGET


					1QTA9P992C

GSK-356278

INHIBITOR -> TARGET

Qualification:

IC50

Amount:


					7GQT2M8W42

YM-976

INHIBITOR -> TARGET


					0P6C6ZOP5U

Roflumilast

INHIBITOR -> TARGET


					67GXQ6WCC6

OGLEMILAST

INHIBITOR -> TARGET

Qualification:

IC50

Amount:


					I5DGT51IB8

Nerandomilast

WEAK INHIBITOR->TARGET

Qualification:

IC50

Amount:


					4QX9BK9E7P

MUFEMILAST

INHIBITOR -> TARGET

Comments:

Claims inhibition PDE4 did not mention any specific isoform

Amount:


					EWD26AFN9G

ICI-58301

INHIBITOR -> TARGET

Comments:

MAYBE NONSELECTIVE

Amount:


					2O43FXG9IG

HT-0712

INHIBITOR -> TARGET

Qualification:

IC50

Amount:


					K676NL63N7

ROLIPRAM

INHIBITOR -> TARGET


					MOC9KI2UHA

CBS-3595

INHIBITOR -> TARGET


					WU2447D3WJ

GPD-1116

INHIBITOR -> TARGET

Comments:

Representative PDE4

Amount:


					2D6GK059SR

GSK-256066

INHIBITOR -> TARGET


					ZL6XTZ7R7K

4-(8-(3-FLUOROPHENYL)(1,7)NAPHTHYRIDIN6-YL)-TRANS-CYCLOHEXANECARBOXYLIC ACID

INHIBITOR -> TARGET

Qualification:

IC50

Amount:


					D29190G2GW

ONO-6126

INHIBITOR -> TARGET

5D7022962A

TOFIMILAST

INHIBITOR -> TARGET


					MUY3M35C3Q

LEO-39652

INHIBITOR -> TARGET

Qualification:

IC50

Amount:


					M9TU3M9CNF

CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE PDE4A7

DERIVATIVE -> PARENT

Amount:


					0984EU6E2F

TRANIMILAST

INHIBITOR -> TARGET


					F49V1L3QBD

ELBIMILAST

INHIBITOR -> TARGET

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID SUBSTITUTION	[1_152] [1_157] [1_165] [1_346] [1_686] [1_688]		S		DEXFOSFOSERINE	VI4F0K069V

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT	CHEMICAL