Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C23H27FN4O4 |
| Molecular Weight | 442.4833 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=CC2=NC(=NC(N[C@@H]3CNC[C@H]3C(C)(C)O)=C2C=C1OC)C4=CC(F)=CC=C4O
InChI
InChIKey=HZASIAXCPXTISQ-NVXWUHKLSA-N
InChI=1S/C23H27FN4O4/c1-23(2,30)15-10-25-11-17(15)27-21-13-8-19(31-3)20(32-4)9-16(13)26-22(28-21)14-7-12(24)5-6-18(14)29/h5-9,15,17,25,29-30H,10-11H2,1-4H3,(H,26,27,28)/t15-,17-/m1/s1
| Molecular Formula | C23H27FN4O4 |
| Molecular Weight | 442.4833 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
CCT241533, a 2-(quinazolin-2-yl)phenol compound, is an ATP competitive inhibitor of checkpoint kinase CHK2. CCT241533 blocked CHK2 activity in human tumor cell lines in response to DNA damage. CCT241533 significantly potentiates the cytotoxicity of PARP inhibitors. CCT241533 demonstrated a concentration dependent radioprotective effect in mouse thymocytes was demonstrated.
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 23:39:31 GMT 2025
by
admin
on
Mon Mar 31 23:39:31 GMT 2025
|
| Record UNII |
79D8PWX59X
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Preferred Name | English | ||
|
Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
79D8PWX59X
Created by
admin on Mon Mar 31 23:39:31 GMT 2025 , Edited by admin on Mon Mar 31 23:39:31 GMT 2025
|
PRIMARY | |||
|
135564841
Created by
admin on Mon Mar 31 23:39:31 GMT 2025 , Edited by admin on Mon Mar 31 23:39:31 GMT 2025
|
PRIMARY | |||
|
1262849-73-9
Created by
admin on Mon Mar 31 23:39:31 GMT 2025 , Edited by admin on Mon Mar 31 23:39:31 GMT 2025
|
PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
|
ACTIVE MOIETY |
