U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C19H22N2
Molecular Weight 278.3914
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DEPRAMINE

SMILES

CN(C)CCCN1C2=CC=CC=C2C=CC3=C1C=CC=C3

InChI

InChIKey=AFBYHZACPPSJKD-UHFFFAOYSA-N
InChI=1S/C19H22N2/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21/h3-6,8-13H,7,14-15H2,1-2H3

HIDE SMILES / InChI

Molecular Formula C19H22N2
Molecular Weight 278.3914
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Depramine is a dibenzazepine derivative. Its chemical structure is related to imipramine and it has antidepressant effects as well as anti-Parkinson effects. Dimepramine fumarate is an anticholinergic agent and inhibits the uptake of norepinephrine. The anticataleptic effect of dimepramine fumarate is attributed to its anticholinergic properties and to its probable role in central adrenergic and/or dopaminergic stimulation. The drug tends to decrease autonomic arousal responses of Parkinson patients as measured by resting conductance levels, number of fluctuations in skin conduction per minute, orienting response, and habituation rate. Depramine is used for the treatment of obsessive compulsive disorder, obsessions and phobias, panic disorder, cataplexy associated with narcolepsy, major depressive disorder, and chronic pain. It can help ease the symptoms in each of these conditions. It works by interfering with the brain chemical serotonin. Side effects of depramine are: dizziness, irritability, blurred vision, dry mouth, nausea or vomiting, swelling of face and feet, acid or sour stomach, constipation, shaking of hands or feet, mouth ulcers, irregular menstrual periods.

Approval Year

Patents

Patents

Sample Use Guides

50 to 225 mg for about three weeks daily
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Sat Dec 16 10:59:13 GMT 2023
Edited
by admin
on Sat Dec 16 10:59:13 GMT 2023
Record UNII
77C3T28736
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
DEPRAMINE
INN   WHO-DD  
INN  
Official Name English
GP-31406
Code English
BALIPRAMINE
Common Name English
IMIPRAMINE HYDROCHLORIDE IMPURITY B [EP IMPURITY]
Common Name English
GP 31406
Code English
Depramine [WHO-DD]
Common Name English
depramine [INN]
Common Name English
5-(3-(DIMETHYLAMINO)PROPYL)-5H-DIBENZ(B,F)AZEPINE
Systematic Name English
DEPRAMINE [USP-RS]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C265
Created by admin on Sat Dec 16 10:59:13 GMT 2023 , Edited by admin on Sat Dec 16 10:59:13 GMT 2023
Code System Code Type Description
INN
3450
Created by admin on Sat Dec 16 10:59:13 GMT 2023 , Edited by admin on Sat Dec 16 10:59:13 GMT 2023
PRIMARY
PUBCHEM
67534
Created by admin on Sat Dec 16 10:59:13 GMT 2023 , Edited by admin on Sat Dec 16 10:59:13 GMT 2023
PRIMARY
CAS
303-54-8
Created by admin on Sat Dec 16 10:59:13 GMT 2023 , Edited by admin on Sat Dec 16 10:59:13 GMT 2023
PRIMARY
FDA UNII
77C3T28736
Created by admin on Sat Dec 16 10:59:13 GMT 2023 , Edited by admin on Sat Dec 16 10:59:13 GMT 2023
PRIMARY
RS_ITEM_NUM
1171397
Created by admin on Sat Dec 16 10:59:13 GMT 2023 , Edited by admin on Sat Dec 16 10:59:13 GMT 2023
PRIMARY
SMS_ID
100000083182
Created by admin on Sat Dec 16 10:59:13 GMT 2023 , Edited by admin on Sat Dec 16 10:59:13 GMT 2023
PRIMARY
NCI_THESAURUS
C78014
Created by admin on Sat Dec 16 10:59:13 GMT 2023 , Edited by admin on Sat Dec 16 10:59:13 GMT 2023
PRIMARY
EVMPD
SUB06981MIG
Created by admin on Sat Dec 16 10:59:13 GMT 2023 , Edited by admin on Sat Dec 16 10:59:13 GMT 2023
PRIMARY
ChEMBL
CHEMBL2104158
Created by admin on Sat Dec 16 10:59:13 GMT 2023 , Edited by admin on Sat Dec 16 10:59:13 GMT 2023
PRIMARY
WIKIPEDIA
Depramine
Created by admin on Sat Dec 16 10:59:13 GMT 2023 , Edited by admin on Sat Dec 16 10:59:13 GMT 2023
PRIMARY
EPA CompTox
DTXSID90184388
Created by admin on Sat Dec 16 10:59:13 GMT 2023 , Edited by admin on Sat Dec 16 10:59:13 GMT 2023
PRIMARY
MESH
C012269
Created by admin on Sat Dec 16 10:59:13 GMT 2023 , Edited by admin on Sat Dec 16 10:59:13 GMT 2023
PRIMARY
Related Record Type Details
PARENT -> IMPURITY
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
PARENT -> IMPURITY
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Related Record Type Details
ACTIVE MOIETY