MOTEXAFIN

Details

Stereochemistry	ACHIRAL
Molecular Formula	C48H67N5O10
Molecular Weight	874.0731
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCC1=C2NC(C=C3N=C(\C=N\C4=CC(OCCOCCOCCOC)=C(OCCOCCOCCOC)C=C4\N=C\C5=NC(=C2)C(CCCO)=C5C)C(C)=C3CCCO)=C1CC

InChI

InChIKey=AHNIKTNNZJNCFN-CNEPGKQSSA-N

InChI=1S/C48H67N5O10/c1-7-35-36(8-2)40-28-42-38(12-10-14-55)34(4)46(53-42)32-50-44-30-48(63-26-24-61-22-20-59-18-16-57-6)47(62-25-23-60-21-19-58-17-15-56-5)29-43(44)49-31-45-33(3)37(11-9-13-54)41(52-45)27-39(35)51-40/h27-32,51,54-55H,7-26H2,1-6H3/b39-27-,40-28-,41-27-,42-28-,45-31-,46-32-,49-31+,49-43+,50-32+,50-44+

HIDE SMILES / InChI

Molecular Formula	C48H69N5O10
Molecular Weight	876.089
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/17266469 | https://www.ncbi.nlm.nih.gov/pubmed/26599802 | https://www.ncbi.nlm.nih.gov/pubmed/19640206

Motexafin is texaphyrin patented by pharmaceutical company Pharmacyclics, Inc. as chelating agents useful for the treatment of neoplastic and cardiovascular disease. The MRI-detectable gadolinium complex of motexafin was studied as a redox modulator that selectively targets tumor cells.

Originator

Approval Year

PubMed

Title	Date	PubMed
Motexafin gadolinium in the treatment of brain metastases.	2007 Feb	17266469
Motexafin gadolinium: a novel radiosensitizer for brain tumors.	2007 Jun	17555388

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:30:45 GMT 2023` Edited by `admin` on `Fri Dec 15 16:30:45 GMT 2023`
Record UNII	75QG9WGN4U
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

MOTEXAFIN

Official Name

English

8,11-IMINO-3,6:16,13-DINITRILO-1,18-BENZODIAZACYCLOEICOSINE-5,14-DIPROPANOL, 9,10-DIETHYL-20,21-BIS(2-(2-(2-METHOXYETHOXY)ETHOXY)ETHOXY)-4,15-DIMETHYL-

Common Name

English

Motexafin [WHO-DD]

Common Name

English

motexafin [INN]

Common Name

English

Code System Code Type Description

PUBCHEM

151071