Motexafin hydrochloride

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C48H66N5O10.ClH
Molecular Weight	909.526
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CCc1c(CC)c2cc3nc(cnc4cc(OCCOCCOCCOC)c(OCCOCCOCCOC)cc4ncc5nc(cc1n2)c(CCCO)c5C)c(C)c3CCCO

InChI

InChIKey=YTGKTHDEEFVADV-CWLLKONLSA-N

InChI=1S/C48H67N5O10.ClH/c1-7-35-36(8-2)40-28-42-38(12-10-14-55)34(4)46(53-42)32-50-44-30-48(63-26-24-61-22-20-59-18-16-57-6)47(62-25-23-60-21-19-58-17-15-56-5)29-43(44)49-31-45-33(3)37(11-9-13-54)41(52-45)27-39(35)51-40;/h27-32,51,54-55H,7-26H2,1-6H3;1H/b39-27-,40-28-,41-27-,42-28-,45-31-,46-32-,49-31+,49-43+,50-32+,50-44+;

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C48H66N5O10
Molecular Weight	873.0651
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/17266469 | https://www.ncbi.nlm.nih.gov/pubmed/26599802 | https://www.ncbi.nlm.nih.gov/pubmed/19640206

Motexafin is texaphyrin patented by pharmaceutical company Pharmacyclics, Inc. as chelating agents useful for the treatment of neoplastic and cardiovascular disease. The MRI-detectable gadolinium complex of motexafin was studied as a redox modulator that selectively targets tumor cells.

Originator

Approval Year

PubMed

Title	Date	PubMed
Motexafin gadolinium: a novel radiosensitizer for brain tumors.	2007-06	17555388
Motexafin gadolinium in the treatment of brain metastases.	2007-02	17266469

Patents

Substance Class	Chemical Created by `admin` on `Wed Apr 02 06:42:21 GMT 2025` Edited by `admin` on `Wed Apr 02 06:42:21 GMT 2025`
Record UNII	X4BY26ZT9J
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Motexafin hydrochloride

Systematic Name

English

8,11-Imino-3,6:16,13-dinitrilo-1,18-benzodiazacycloeicosine-5,14-dipropanol, 9,10-diethyl-20,21-bis[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]-4,15-dimethyl-, hydrochloride

Preferred Name

English

Code System Code Type Description

CAS

917562-97-1

Created by admin on Wed Apr 02 06:42:21 GMT 2025 , Edited by admin on Wed Apr 02 06:42:21 GMT 2025

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FDA UNII

X4BY26ZT9J

Created by admin on Wed Apr 02 06:42:21 GMT 2025 , Edited by admin on Wed Apr 02 06:42:21 GMT 2025

PRIMARY

Related Record Type Details


					75QG9WGN4U

MOTEXAFIN

PARENT -> SALT/SOLVATE

Amount: