Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C17H18N2 |
| Molecular Weight | 250.3382 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CN1C(CC2=C(C=CC=C2)N=C1C)C3=CC=CC=C3
InChI
InChIKey=STDYWHYUOSSCBO-UHFFFAOYSA-N
InChI=1S/C17H18N2/c1-13-18-16-11-7-6-10-15(16)12-17(19(13)2)14-8-4-3-5-9-14/h3-11,17H,12H2,1-2H3
| Molecular Formula | C17H18N2 |
| Molecular Weight | 250.3382 |
| Charge | 0 |
| Count |
|
| Stereochemistry | RACEMIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Optical Activity | ( + / - ) |
Dazepinil (HRP 543) is a 1,3-benzodiazepine antidepressant, developed by Hoerscht in the early 1980s. In mouse tests, dazepinil inhibited tetrabenazine-induced ptosis and potentiated yohimbine toxicity. In vitro, dazepinil inhibited norepinephrine and serotonin uptake into rat brain synaptosomes and lacked anticholinergic activity.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| (+/-)-4-Aryl-4,5-dihydro-3H-1,3-benzodiazepines. 1. Synthesis and evaluation of (+/-)-4,5-dihydro-2,3-dimethyl-4-phenyl-3H-1,3-benzodiazepine and analogues as potential antidepressant agents. | 1982-04 |
|
| (+/-)-4-Aryl-4,5-dihydro-3H-1,3-benzodiazepines. 2. Nuclear-substituted analogues of (+/-)-4,5-dihydro-2,3-dimethyl-4-phenyl-3H-1,3-benzodiazepine and (+/-)-4,5-dihydro-2-ethyl-3-methyl-4-phenyl-3H-1,3-benzodiazepine as potential antidepressant agents. | 1982-04 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Wed Apr 02 09:59:20 GMT 2025
by
admin
on
Wed Apr 02 09:59:20 GMT 2025
|
| Record UNII |
730EPY2HSM
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Official Name | English | ||
|
Preferred Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
730EPY2HSM
Created by
admin on Wed Apr 02 09:59:20 GMT 2025 , Edited by admin on Wed Apr 02 09:59:20 GMT 2025
|
PRIMARY | |||
|
SUB06919MIG
Created by
admin on Wed Apr 02 09:59:20 GMT 2025 , Edited by admin on Wed Apr 02 09:59:20 GMT 2025
|
PRIMARY | |||
|
100000083445
Created by
admin on Wed Apr 02 09:59:20 GMT 2025 , Edited by admin on Wed Apr 02 09:59:20 GMT 2025
|
PRIMARY | |||
|
CHEMBL117042
Created by
admin on Wed Apr 02 09:59:20 GMT 2025 , Edited by admin on Wed Apr 02 09:59:20 GMT 2025
|
PRIMARY | |||
|
75991-50-3
Created by
admin on Wed Apr 02 09:59:20 GMT 2025 , Edited by admin on Wed Apr 02 09:59:20 GMT 2025
|
PRIMARY | |||
|
C166982
Created by
admin on Wed Apr 02 09:59:20 GMT 2025 , Edited by admin on Wed Apr 02 09:59:20 GMT 2025
|
PRIMARY | |||
|
5926
Created by
admin on Wed Apr 02 09:59:20 GMT 2025 , Edited by admin on Wed Apr 02 09:59:20 GMT 2025
|
PRIMARY | |||
|
53432
Created by
admin on Wed Apr 02 09:59:20 GMT 2025 , Edited by admin on Wed Apr 02 09:59:20 GMT 2025
|
PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
|
ENANTIOMER -> RACEMATE | |||
|
|
SALT/SOLVATE -> PARENT | |||
|
|
ENANTIOMER -> RACEMATE |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
|
ACTIVE MOIETY |
