DAZEPINIL HYDROCHLORIDE

Details

Stereochemistry	RACEMIC
Molecular Formula	C17H18N2.ClH
Molecular Weight	286.799
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CN1C(CC2=CC=CC=C2N=C1C)C3=CC=CC=C3

InChI

InChIKey=RKGYKBFILSMGSV-UHFFFAOYSA-N

InChI=1S/C17H18N2.ClH/c1-13-18-16-11-7-6-10-15(16)12-17(19(13)2)14-8-4-3-5-9-14;/h3-11,17H,12H2,1-2H3;1H

HIDE SMILES / InChI

Molecular Formula	C17H18N2
Molecular Weight	250.3382
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/7200144

Dazepinil (HRP 543) is a 1,3-benzodiazepine antidepressant, developed by Hoerscht in the early 1980s. In mouse tests, dazepinil inhibited tetrabenazine-induced ptosis and potentiated yohimbine toxicity. In vitro, dazepinil inhibited norepinephrine and serotonin uptake into rat brain synaptosomes and lacked anticholinergic activity.

Originator

Approval Year

PubMed

Title	Date	PubMed
(+/-)-4-Aryl-4,5-dihydro-3H-1,3-benzodiazepines. 1. Synthesis and evaluation of (+/-)-4,5-dihydro-2,3-dimethyl-4-phenyl-3H-1,3-benzodiazepine and analogues as potential antidepressant agents.	1982 Apr	7200144
(+/-)-4-Aryl-4,5-dihydro-3H-1,3-benzodiazepines. 2. Nuclear-substituted analogues of (+/-)-4,5-dihydro-2,3-dimethyl-4-phenyl-3H-1,3-benzodiazepine and (+/-)-4,5-dihydro-2-ethyl-3-methyl-4-phenyl-3H-1,3-benzodiazepine as potential antidepressant agents.	1982 Apr	7069712

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:24:09 GMT 2023` Edited by `admin` on `Fri Dec 15 16:24:09 GMT 2023`
Record UNII	OV95UQH1ED
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DAZEPINIL HYDROCHLORIDE

Official Name

English

HRP 543

Code

English

DAZEPINIL HYDROCHLORIDE [USAN]

Common Name

English

3H-1,3-BENZODIAZEPINE, 4,5-DIHYDRO-2,3-DIMETHYL-4-PHENYL-, MONOHYDROCHLORIDE, (±)-

Common Name

English

P 76 254

Code

English

P-76-254

Code

English

HRP-543

Code

English

P 76 2543

Code

English

DAZEPINIL HCL

Common Name

English

(±)-4,5-DIHYDRO-2,3-DIMETHYL-4-PHENYL-3H-1,3-BENZODIAZEPINE MONOHYDROCHLORIDE

Systematic Name

English

P-76-2543

Code

English

Code System Code Type Description

FDA UNII

OV95UQH1ED