U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C18H21NO3
Molecular Weight 299.3642
Optical Activity ( - )
Defined Stereocenters 4 / 4
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of HYDROCODONE

SMILES

[H][C@@]12OC3=C(OC)C=CC4=C3[C@@]15CCN(C)[C@H](C4)[C@]5([H])CCC2=O

InChI

InChIKey=LLPOLZWFYMWNKH-CMKMFDCUSA-N
InChI=1S/C18H21NO3/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19/h3,6,11-12,17H,4-5,7-9H2,1-2H3/t11-,12+,17-,18-/m0/s1

HIDE SMILES / InChI
Molecular Formula C18H21NO3
Molecular Weight 299.3642
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 4 / 4
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

Benzhydrocodone is a prodrug of hydrocodone. Benzhydrocodone is formed by covalently bonding hydrocodone to benzoic acid. Benzhydrocodone itself is not pharmacologically active, but must be metabolized to hydrocodone by enzymes in the intestinal tract to optimally deliver its pharmacologic effects. Hydrocodone is a full agonist of the opioid receptors with a higher affinity for the mu-opioid receptor. Upon binding, hydrocodone produces an analgesic effect with no ceiling. APADAZ a combination of benzhydrocodone and acetaminophen is FDA approved and indicated for the short-term (no more than 14 days) management of acute pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate. APADAZ, even when taken as recommended, can result in addiction, abuse, and misuse, which can lead to overdose and death.

CNS Activity

Approval Year

1943
64
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8360
ZOHYDRO ER

Approved Use

ZOHYDRO ER is an opioid agonist indicated for the management of pain severe enough to require daily, around-the-clock, long-term opioid treatment and for which alternative treatment options are inadequate.

Launch Date

1.38257275E12
Primary
Approved
8360
APADAZ

Approved Use

APADAZ is a combination of benzhydrocodone, a prodrug of the opioid agonist hydrocodone, and acetaminophen, and is indicated for the short-term (no more than 14 days) management of acute pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate.

Launch Date

1.54647357E12
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
10.1 ng/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/27138027/
15 mg single, oral
dose: 15 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
HYDROCODONE plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
23.6 ng/mL
DRUG LABEL
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/005213s039lbl.pdf
10 mg single, oral
dose: 10 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
HYDROCODONE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
155 ng × h/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/27138027/
15 mg single, oral
dose: 15 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
HYDROCODONE plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
10.2 h
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/27138027/
15 mg single, oral
dose: 15 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
HYDROCODONE plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
4 h
DRUG LABEL
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/005213s039lbl.pdf
10 mg single, oral
dose: 10 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
HYDROCODONE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
Funbound

Funbound

ValueDoseCo-administeredAnalytePopulation
55%
DRUG LABEL
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/005213s039lbl.pdf
10 mg single, oral
dose: 10 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
HYDROCODONE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
Doses

Doses

DosePopulationAdverse events​
30 mg multiple, oral (total)
Overdose
Dose: 30 mg
Route: oral
Route: multiple
Dose: 30 mg
Co-administed with::
clarithromycin
valproic acid(250 mg, 2 times per day)
Sources:
https://pubmed.ncbi.nlm.nih.gov/20837591
unhealthy, 5 years
n = 1
Health Status: unhealthy
Condition: cold
Age Group: 5 years
Sex: F
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/20837591
Other AEs: Adverse event...
Other AEs:
Adverse event (grade 5)
Sources:
https://pubmed.ncbi.nlm.nih.gov/20837591
160 mg 1 times / day multiple, oral
Highest studied dose
Dose: 160 mg, 1 times / day
Route: oral
Route: multiple
Dose: 160 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/206627s000lbl.pdf
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206627Orig1s000MedR.pdf
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/206627s000lbl.pdf
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206627Orig1s000MedR.pdf
Other AEs: Electrocardiogram QTc interval prolonged...
Other AEs:
Electrocardiogram QTc interval prolonged
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/206627s000lbl.pdf
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206627Orig1s000MedR.pdf
20 mg 1 times / day multiple, oral
Recommended
Dose: 20 mg, 1 times / day
Route: oral
Route: multiple
Dose: 20 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/206627s000lbl.pdf
pregnant, adult
Health Status: pregnant
Age Group: adult
Sex: F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/206627s000lbl.pdf
Other AEs: Withdrawal syndrome neonatal...
Other AEs:
Withdrawal syndrome neonatal
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/206627s000lbl.pdf
20 mg 1 times / day multiple, oral
Recommended
Dose: 20 mg, 1 times / day
Route: oral
Route: multiple
Dose: 20 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/206627s000lbl.pdf
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/206627s000lbl.pdf
Other AEs: Respiratory depression, Addiction...
Other AEs:
Respiratory depression (grade 5)
Addiction
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/206627s000lbl.pdf
20 mg 1 times / day multiple, oral
Dose: 20 mg, 1 times / day
Route: oral
Route: multiple
Dose: 20 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206627Orig1s000MedR.pdf
Page: p. 115
unhealthy, adult
n = 296
Health Status: unhealthy
Age Group: adult
Sex: M+F
Population Size: 296
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206627Orig1s000MedR.pdf
Page: p. 115
Disc. AE: Vomiting, Nausea...
AEs leading to
discontinuation/dose reduction:
Vomiting (1%)
Nausea (1%)
Headache (1%)
Dizziness (1%)
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206627Orig1s000MedR.pdf
Page: p. 115
AEs

AEs

AESignificanceDosePopulation
Adverse event grade 5
30 mg multiple, oral (total)
Overdose
Dose: 30 mg
Route: oral
Route: multiple
Dose: 30 mg
Co-administed with::
clarithromycin
valproic acid(250 mg, 2 times per day)
Sources:
https://pubmed.ncbi.nlm.nih.gov/20837591
unhealthy, 5 years
n = 1
Health Status: unhealthy
Condition: cold
Age Group: 5 years
Sex: F
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/20837591
Electrocardiogram QTc interval prolonged
160 mg 1 times / day multiple, oral
Highest studied dose
Dose: 160 mg, 1 times / day
Route: oral
Route: multiple
Dose: 160 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/206627s000lbl.pdf
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206627Orig1s000MedR.pdf
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/206627s000lbl.pdf
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206627Orig1s000MedR.pdf
Withdrawal syndrome neonatal
20 mg 1 times / day multiple, oral
Recommended
Dose: 20 mg, 1 times / day
Route: oral
Route: multiple
Dose: 20 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/206627s000lbl.pdf
pregnant, adult
Health Status: pregnant
Age Group: adult
Sex: F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/206627s000lbl.pdf
Addiction
20 mg 1 times / day multiple, oral
Recommended
Dose: 20 mg, 1 times / day
Route: oral
Route: multiple
Dose: 20 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/206627s000lbl.pdf
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/206627s000lbl.pdf
Respiratory depression grade 5
20 mg 1 times / day multiple, oral
Recommended
Dose: 20 mg, 1 times / day
Route: oral
Route: multiple
Dose: 20 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/206627s000lbl.pdf
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/206627s000lbl.pdf
Dizziness 1%
Disc. AE
20 mg 1 times / day multiple, oral
Dose: 20 mg, 1 times / day
Route: oral
Route: multiple
Dose: 20 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206627Orig1s000MedR.pdf
Page: p. 115
unhealthy, adult
n = 296
Health Status: unhealthy
Age Group: adult
Sex: M+F
Population Size: 296
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206627Orig1s000MedR.pdf
Page: p. 115
Headache 1%
Disc. AE
20 mg 1 times / day multiple, oral
Dose: 20 mg, 1 times / day
Route: oral
Route: multiple
Dose: 20 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206627Orig1s000MedR.pdf
Page: p. 115
unhealthy, adult
n = 296
Health Status: unhealthy
Age Group: adult
Sex: M+F
Population Size: 296
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206627Orig1s000MedR.pdf
Page: p. 115
Nausea 1%
Disc. AE
20 mg 1 times / day multiple, oral
Dose: 20 mg, 1 times / day
Route: oral
Route: multiple
Dose: 20 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206627Orig1s000MedR.pdf
Page: p. 115
unhealthy, adult
n = 296
Health Status: unhealthy
Age Group: adult
Sex: M+F
Population Size: 296
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206627Orig1s000MedR.pdf
Page: p. 115
Vomiting 1%
Disc. AE
20 mg 1 times / day multiple, oral
Dose: 20 mg, 1 times / day
Route: oral
Route: multiple
Dose: 20 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206627Orig1s000MedR.pdf
Page: p. 115
unhealthy, adult
n = 296
Health Status: unhealthy
Age Group: adult
Sex: M+F
Population Size: 296
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206627Orig1s000MedR.pdf
Page: p. 115
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG
substrate
1709
substrate
1193
inhibitor
1599

OverviewOther

Other InhibitorOther SubstrateOther Inducer
CYP2B6
660

CYP2C19
985
Drug as victim

Drug as victim

TargetModalityActivityMetaboliteClinical evidence
CYP2B6
660
 minor
CYP2C19
985
 minor
CYP2D6
1193
 yes
yes (co-administration study)
Comment: The 90% confidence interval (CI) of the geometric means for hydrocodone AUCinf (98 to 115%), AUCt (98 to 115%), and Cmax (93 to 121%) values were within the range of 80 to 125% when a single dose of HYSINGLA ER 20 mg was co-administered with CYP2D6 inhibitor paroxetine
CYP3A4
1709
 yes
yes (co-administration study)
Comment: Co-administration of HYSINGLA ER and CYP3A4 inhibitor ketoconazole increased mean hydrocodone AUC and Cmax by 135% and 78%, respectively;
Tox targets

Tox targets

TargetModalityActivityMetaboliteClinical evidence
hERG
1632
Sourcing

Sourcing

Vendor/AggregatorIDURL
ChEBI
CHEBI:5779
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:5779
ZINC
ZINC000001280665
http://zinc15.docking.org/substances/ZINC000001280665
eMolecules
29539213
https://www.emolecules.com/cgi-bin/more?vid=29539213
PubMed

PubMed

TitleDatePubMed
[Longitudinal study of parameters of respiratory function tests and blood gas analysis in patients with progressive systemic scleroderma].
2001
Opioid formulations: tailoring to the needs in chronic pain.
2001
Cellulose granulomatosis presenting as centrilobular nodules: CT and histologic findings.
2001 Nov
[Learning from experience. Analysis of claims submitted to the National Commission of Medical Arbitration].
2001 Sep-Oct
Complications of intranasal prescription narcotic abuse.
2002 Feb
Esophageal cancer and the esophagus: challenges and potential strategies for selective cytoprotection of the tumor-bearing organ during cancer treatment.
2002 Jan
Combination hydrocodone and ibuprofen versus combination oxycodone and acetaminophen in the treatment of moderate or severe acute low back pain.
2002 Jan
The effectiveness of an anesthetic continuous-infusion device on postoperative pain control.
2002 Jan
Gateways to clinical trials.
2002 Jul-Aug
[Trends in the incidence of hepatic tumors in childhood].
2002 Mar-Apr
Rational use of analgesic combinations.
2002 Oct
Surveillance of drug identification calls: an overlooked poison center responsibility.
2002 Oct
Adverse drug reactions to oxycodone and hydrocodone in CYP2D6 ultrarapid metabolizers.
2003 Aug
I am following a health care professional who, I think, has a drug problem.
2003 Jan
Trials and tribulations: current challenges in conducting clinical trials.
2003 Jan
Hair analysis for opiates: evaluation of washing and incubation procedures.
2003 Jun 5
Misuse of prescribed controlled substances defined by urinalysis.
2003 Mar-Apr
[Spanish scientific production in anesthesiology and resuscitation 1983-1995].
2003 Nov
Withdrawal hyperalgesia after acute opioid physical dependence in nonaddicted humans: a preliminary study.
2003 Nov
Pharmacokinetic drug interactions of morphine, codeine, and their derivatives: theory and clinical reality, Part II.
2003 Nov-Dec
Evaluation of postoperative bupivacaine infusion for pain management after anterior cruciate ligament reconstruction.
2003 Oct
Patterns and trends in opioid use among individuals with back pain in the United States.
2004 Apr 15
1000 office-based hysteroscopies prior to in vitro fertilization: feasibility and findings.
2004 Apr-Jun
Carisoprodol withdrawal syndrome.
2004 Dec
A message of hope.
2004 Fall
Dose-response relationship between opioid use and adverse effects after ambulatory surgery.
2004 Jul
Efficacy of ibuprofen-hydrocodone for the treatment of postoperative pain after periodontal surgery.
2004 Jun
Fatal intravenous fentanyl abuse: four cases involving extraction of fentanyl from transdermal patches.
2004 Jun
Persistent nonmalignant pain and analgesic prescribing patterns in elderly nursing home residents.
2004 Jun
Office visits and analgesic prescriptions for musculoskeletal pain in US: 1980 vs. 2000.
2004 Jun
Hallucinations with zolpidem and fluoxetine in an impaired driver.
2004 Mar
[Detection of thyroid pathology during surgical exploration of the neck for primary hyperthyroidism].
2004 Mar-Apr
[Gender and health in the daily press].
2004 May
Patient-controlled ropivacaine analgesia after arthroscopic subacromial decompression.
2004 May
Topical metronidazole (10 percent) decreases posthemorrhoidectomy pain and improves healing.
2004 May
[Origin and growth of the National Program of Continuous Academic Development for the General Physician].
2004 May-Jun
Local anesthetic infusion pumps improve postoperative pain after inguinal hernia repair: a randomized trial.
2004 Nov
6-oxo-morphinane oximes: pharmacology, chemistry and analytical application.
2004 Oct
Continuous local anesthetic infusion for pain management after outpatient inguinal herniorrhaphy.
2004 Oct
Presurgical intravenous parecoxib sodium and follow-up oral valdecoxib for pain management after laparoscopic cholecystectomy surgery reduces opioid requirements and opioid-related adverse effects.
2004 Oct
Fracture of an endoluminal nitinol stent used in the treatment of tracheal collapse in a dog.
2004 Oct 15
Metaxalone (Skelaxin)-related death.
2004 Sep
Cough suppression during flexible bronchoscopy using combined sedation with midazolam and hydrocodone: a randomised, double blind, placebo controlled trial.
2004 Sep
A 35-year-old physician with opioid dependence.
2004 Sep 15
Selective potentiation of opioid analgesia by nonsteroidal anti-inflammatory drugs.
2005 Apr 8
Detection of hypoventilation during thoracoscopy: combined cutaneous carbon dioxide tension and oximetry monitoring with a new digital sensor.
2005 Feb
A preclinical comparison between different opioids: antinociceptive versus adverse effects.
2005 Feb
The GC-MS detection and characterization of neopine resulting from opium use and codeine metabolism and its potential as an opiate-product-use marker.
2005 Jun
A 46-year-old man with excruciating shoulder pain.
2005 Mar
Oral analgesics for acute nonspecific pain.
2005 Mar 1
Patents

Patents

04272541
12
07321038
10
08491935
42
08569329
42
JP2000501709A
75
JP2005506351A
26
JP2010163446A
20
JP2010509227A
64
JP2011511782A
10
JP2011520977A
49
JP2013241461A
10
JP4806507B2
10

Sample Use Guides

In Vivo Use Guide
APADAZ Immediate-release tablets: 6.12 mg benzhydrocodone (equivalent to 6.67 mg benzhydrocodone hydrochloride) and 325 mg acetaminophen. Initiate treatment with APADAZ at 1 or 2 tablets every 4 to 6 hours as needed for pain. Dosage should not exceed 12 tablets in a 24­ hour period.
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Wed Jul 05 22:36:45 UTC 2023
Edited
by admin
on Wed Jul 05 22:36:45 UTC 2023
Record UNII
6YKS4Y3WQ7
Record Status Validated (UNII)
Record Version
  • Download
Related Record Type
Name Type Language
HYDROCODONE
HSDB   INN   MI   VANDF   WHO-DD  
INN  
Official Name English
OXYCODONE HYDROCHLORIDE, HYDROCODONE- [USP IMPURITY]
Common Name English
Hydrocodone [WHO-DD]
Common Name English
HYDROCODONE [HSDB]
Common Name English
hydrocodone [INN]
Common Name English
HYDROCODON
Common Name English
HYDROCODONE [MI]
Common Name English
HYDROCODONE [VANDF]
Common Name English
DIHYDROCODEINONE
Common Name English
NSC-19044
Code English
HYDROCODONE CII [USP-RS]
Common Name English
HYDROCODONE-
Common Name English
OXYCODONE HYDROCHLORIDE IMPURITY E [EP IMPURITY]
Common Name English
MULTACODIN
Common Name English
(5.ALPHA.)-3-METHOXY-17-METHYL-4,5-EPOXYMORPHINAN-6-ONE
Systematic Name English
(-)-DIHYDROCODEINONE
Common Name English
DIHYDROCODEINE HYDROGEN TARTRATE IMPURITY C [EP IMPURITY]
Common Name English
BEKADID
Brand Name English
Classification Tree Code System Code
WHO-ATC R05DA03
Created by admin on Wed Jul 05 22:36:46 UTC 2023 , Edited by admin on Wed Jul 05 22:36:46 UTC 2023
WHO-VATC QR05DA03
Created by admin on Wed Jul 05 22:36:46 UTC 2023 , Edited by admin on Wed Jul 05 22:36:46 UTC 2023
NCI_THESAURUS C66917
Created by admin on Wed Jul 05 22:36:46 UTC 2023 , Edited by admin on Wed Jul 05 22:36:46 UTC 2023
DEA NO. 9193
Created by admin on Wed Jul 05 22:36:46 UTC 2023 , Edited by admin on Wed Jul 05 22:36:46 UTC 2023
LIVERTOX NBK548700
Created by admin on Wed Jul 05 22:36:46 UTC 2023 , Edited by admin on Wed Jul 05 22:36:46 UTC 2023
NDF-RT N0000000174
Created by admin on Wed Jul 05 22:36:46 UTC 2023 , Edited by admin on Wed Jul 05 22:36:46 UTC 2023
NCI_THESAURUS C1506
Created by admin on Wed Jul 05 22:36:46 UTC 2023 , Edited by admin on Wed Jul 05 22:36:46 UTC 2023
NCI_THESAURUS C67413
Created by admin on Wed Jul 05 22:36:46 UTC 2023 , Edited by admin on Wed Jul 05 22:36:46 UTC 2023
NDF-RT N0000175690
Created by admin on Wed Jul 05 22:36:46 UTC 2023 , Edited by admin on Wed Jul 05 22:36:46 UTC 2023
Code System Code Type Description
FDA UNII
6YKS4Y3WQ7
Created by admin on Wed Jul 05 22:36:46 UTC 2023 , Edited by admin on Wed Jul 05 22:36:46 UTC 2023
PRIMARY
INN
1700
Created by admin on Wed Jul 05 22:36:46 UTC 2023 , Edited by admin on Wed Jul 05 22:36:46 UTC 2023
PRIMARY
WIKIPEDIA
HYDROCODONE
Created by admin on Wed Jul 05 22:36:46 UTC 2023 , Edited by admin on Wed Jul 05 22:36:46 UTC 2023
PRIMARY
HSDB
3097
Created by admin on Wed Jul 05 22:36:46 UTC 2023 , Edited by admin on Wed Jul 05 22:36:46 UTC 2023
PRIMARY
DRUG CENTRAL
1386
Created by admin on Wed Jul 05 22:36:46 UTC 2023 , Edited by admin on Wed Jul 05 22:36:46 UTC 2023
PRIMARY
MERCK INDEX
M6093
Created by admin on Wed Jul 05 22:36:46 UTC 2023 , Edited by admin on Wed Jul 05 22:36:46 UTC 2023
PRIMARY Merck Index
SMS_ID
100000084214
Created by admin on Wed Jul 05 22:36:46 UTC 2023 , Edited by admin on Wed Jul 05 22:36:46 UTC 2023
PRIMARY
ECHA (EC/EINECS)
204-733-9
Created by admin on Wed Jul 05 22:36:46 UTC 2023 , Edited by admin on Wed Jul 05 22:36:46 UTC 2023
PRIMARY
EPA CompTox
DTXSID8023131
Created by admin on Wed Jul 05 22:36:46 UTC 2023 , Edited by admin on Wed Jul 05 22:36:46 UTC 2023
PRIMARY
LACTMED
Hydrocodone
Created by admin on Wed Jul 05 22:36:46 UTC 2023 , Edited by admin on Wed Jul 05 22:36:46 UTC 2023
PRIMARY
DRUG BANK
DB00956
Created by admin on Wed Jul 05 22:36:46 UTC 2023 , Edited by admin on Wed Jul 05 22:36:46 UTC 2023
PRIMARY
NSC
19044
Created by admin on Wed Jul 05 22:36:46 UTC 2023 , Edited by admin on Wed Jul 05 22:36:46 UTC 2023
PRIMARY
DAILYMED
6YKS4Y3WQ7
Created by admin on Wed Jul 05 22:36:46 UTC 2023 , Edited by admin on Wed Jul 05 22:36:46 UTC 2023
PRIMARY
RXCUI
5489
Created by admin on Wed Jul 05 22:36:46 UTC 2023 , Edited by admin on Wed Jul 05 22:36:46 UTC 2023
PRIMARY
RS_ITEM_NUM
1314960
Created by admin on Wed Jul 05 22:36:46 UTC 2023 , Edited by admin on Wed Jul 05 22:36:46 UTC 2023
PRIMARY
CHEBI
5779
Created by admin on Wed Jul 05 22:36:46 UTC 2023 , Edited by admin on Wed Jul 05 22:36:46 UTC 2023
PRIMARY
IUPHAR
7081
Created by admin on Wed Jul 05 22:36:46 UTC 2023 , Edited by admin on Wed Jul 05 22:36:46 UTC 2023
PRIMARY
ChEMBL
CHEMBL1457
Created by admin on Wed Jul 05 22:36:46 UTC 2023 , Edited by admin on Wed Jul 05 22:36:46 UTC 2023
PRIMARY
EVMPD
SUB08063MIG
Created by admin on Wed Jul 05 22:36:46 UTC 2023 , Edited by admin on Wed Jul 05 22:36:46 UTC 2023
PRIMARY
MESH
D006853
Created by admin on Wed Jul 05 22:36:46 UTC 2023 , Edited by admin on Wed Jul 05 22:36:46 UTC 2023
PRIMARY
CAS
125-29-1
Created by admin on Wed Jul 05 22:36:46 UTC 2023 , Edited by admin on Wed Jul 05 22:36:46 UTC 2023
PRIMARY
NCI_THESAURUS
C62033
Created by admin on Wed Jul 05 22:36:46 UTC 2023 , Edited by admin on Wed Jul 05 22:36:46 UTC 2023
PRIMARY
PUBCHEM
5284569
Created by admin on Wed Jul 05 22:36:46 UTC 2023 , Edited by admin on Wed Jul 05 22:36:46 UTC 2023
PRIMARY
Related Record Type Details
Structure of HYDROCODONE HYDROIODIDE
SALT/SOLVATE -> PARENT
APPROXIMATE PURE ANHYDROUS DRUG CONTENT (IN PERCENT)
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SALT/SOLVATE -> PARENT
APPROXIMATE PURE ANHYDROUS DRUG CONTENT (IN PERCENT)
Structure of HYDROCODONE TANNATE
SALT/SOLVATE -> PARENT
Structure of HYDROCODONE HYDROCHLORIDE MONOHYDRATE
SALT/SOLVATE -> PARENT
APPROXIMATE PURE ANHYDROUS DRUG CONTENT (IN PERCENT)
Structure of HYDROCODONE BITARTRATE
SALT/SOLVATE -> PARENT
APPROXIMATE PURE ANHYDROUS DRUG CONTENT (IN PERCENT)
Structure of HYDROCODONE BITARTRATE ANHYDROUS
SALT/SOLVATE -> PARENT
Structure of HYDROCODONE TEREPHTHALATE
DERIVATIVE -> PARENT
APPROXIMATE PURE ANHYDROUS DRUG CONTENT (IN PERCENT)
Structure of HYDROCODONE HYDROCHLORIDE DIHYDRATE
SALT/SOLVATE -> PARENT
APPROXIMATE PURE ANHYDROUS DRUG CONTENT (IN PERCENT)
HYDROCODONE POLISTIREX
SUB_CONCEPT->SUBSTANCE
Structure of HYDROCODONE HYDROCHLORIDE
SALT/SOLVATE -> PARENT
HYDROCODONE RESIN COMPLEX
SUB_CONCEPT->SUBSTANCE
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METABOLITE -> PARENT
trace amount
MINOR
URINE
Structure of HYDROMORPHOL, 6.BETA.-
METABOLITE -> PARENT
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MINOR
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Structure of BENZHYDROCODONE
PRODRUG -> METABOLITE ACTIVE
Structure of NORHYDROCODONE
METABOLITE ACTIVE -> PARENT
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PARENT -> IMPURITY
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USP
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PARENT -> IMPURITY
sum of impurities D and E: not more than 10 times the area of the peak due to oxycodone in the chromatogram obtained with reference solution (b) (1.0 per cent)
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Related Record Type Details
Structure of HYDROCODONE
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