PLIXACABTAGENE AUTOLEUCEL

Approval Year

Substance Class	Structurally Diverse Created by `admin` on `Wed Apr 02 10:15:30 GMT 2025` Edited by `admin` on `Wed Apr 02 10:15:30 GMT 2025`
Source Materials Class	ORGANISM
Source Materials Type	AUTOLOGOUS HUMAN
Source Materials State	LIVE GENETICALLY MODIFIED
Source Materials Parent	`G0T704E6Z3` HOMO SAPIENS WHOLE
Part	blood
Fraction Material Type	cell
Fraction Name	peripheral blood mononuclear cells
Record UNII	6Y6SEX9G35
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

AUTOLOGOUS T CELLS OBTAINED FROM PERIPHERAL BLOOD MONONUCLEAR CELLS BY LEUKAPHERESIS, TRANSDUCED WITH A SELF-INACTIVATING, NON-REPLICATING LENTIVIRAL VECTOR, ENCODING A CHIMERIC ANTIGEN RECEPTOR (CAR) TARGETING CD19. THE EXPRESSED TRANSGENE COMPRISES A G

Preferred Name

English

PLIXACABTAGENE AUTOLEUCEL

Official Name

English

plixacabtagene autoleucel [INN]

Common Name

English

Code System Code Type Description

NCI_THESAURUS

C203091

Created by admin on Wed Apr 02 10:15:30 GMT 2025 , Edited by admin on Wed Apr 02 10:15:30 GMT 2025

PRIMARY

FDA UNII

6Y6SEX9G35

Created by admin on Wed Apr 02 10:15:30 GMT 2025 , Edited by admin on Wed Apr 02 10:15:30 GMT 2025

PRIMARY

INN

11931

Created by admin on Wed Apr 02 10:15:30 GMT 2025 , Edited by admin on Wed Apr 02 10:15:30 GMT 2025

PRIMARY

Related Record Type Details


					TYR224OK86

CD19 POSITIVE CELLS

TARGET->CYTOTOXIC T-CELL

Amount:

Related Record Type Details


					6Y6SEX9G35

PLIXACABTAGENE AUTOLEUCEL

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
INSERTED GENE EXPRESSION VECTOR					PLIXACABTAGENE AUTOLEUCEL TRANSGENE INSERT	5VHE3TN4GY
VECTOR EXPRESSED PROTEIN					PLIXACABTAGENE AUTOLEUCEL CHIMERIC ANTIGEN RECEPTOR (CAR) TARGETING CD19	C8LG4HT3LN