Details
Stereochemistry | RACEMIC |
Molecular Formula | C18H17NO3 |
Molecular Weight | 295.3325 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CCC(C(O)=O)C1=CC=C(C=C1)N2CC3=CC=CC=C3C2=O
InChI
InChIKey=AYDXAULLCROVIT-UHFFFAOYSA-N
InChI=1S/C18H17NO3/c1-2-15(18(21)22)12-7-9-14(10-8-12)19-11-13-5-3-4-6-16(13)17(19)20/h3-10,15H,2,11H2,1H3,(H,21,22)
Molecular Formula | C18H17NO3 |
Molecular Weight | 295.3325 |
Charge | 0 |
Count |
|
Stereochemistry | RACEMIC |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Optical Activity | ( + / - ) |
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/1965501
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1965501
Indobufen inhibits platelet aggregation by reversibly inhibiting the platelet cyclooxygenase enzyme thereby suppressing thromboxane synthesis. Indobufen under brand name ibustrin is used in Italy for the following conditions: cerebrovascular insufficiency, atherosclerosis of peripheral and cerebral vessels, thrombophlebitis, deep vein thrombosis, and diabetes mellitus. In addition, this drug has been investigated in the phase II clinical trial for the prevention of thromboembolic events in patients with nonrheumatic atrial fibrillation. After oral administration, it is quickly and completely absorbed.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: CHEMBL2094253 Sources: https://www.ncbi.nlm.nih.gov/pubmed/1965501 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Preventing | Unknown Approved UseUnknown |
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Preventing | Ibustrin Approved UseUnknown |
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Preventing | Ibustrin Approved UseUnknown |
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Preventing | Ibustrin Approved UseUnknown |
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Palliative | Ibustrin Approved UseUnknown |
PubMed
Title | Date | PubMed |
---|---|---|
Resolution of indobufen enantiomers by capillary zone electrophoresis. Pharmacokinetic studies of human serum. | 2004 Apr 2 |
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Anticoagulants versus antiplatelet therapy for preventing stroke in patients with nonrheumatic atrial fibrillation and a history of stroke or transient ischemic attack. | 2004 Oct 18 |
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[Recurrent hemoptysis following thienopyridines and amiodarone administration. therapeutic dilemma]. | 2005 Aug |
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Indobufen inhibits tissue factor in human monocytes through a thromboxane-mediated mechanism. | 2006 Jan |
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Antithrombotic therapy in cardiac embolism. | 2010 Aug |
Sample Use Guides
In Vivo Use Guide
Sources: https://clinicaltrials.gov/ct2/show/NCT00244426
indobufen capsules 100 and 200 mg
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3666587
At low concentrations (10 microM), indobufen completely inhibited secondary platelet aggregation, the release reaction and TxB2 production stimulated by ADP, epinephrine and low concentrations of platelet-activating factor (PAF acether). Higher concentrations of indobufen (100 microM) completely inhibited TxB2 production, platelet aggregation and ATP release induced by arachidonic acid (1 mM) or collagen (2 micrograms/ml). The inhibitory effect was partially overcome by higher concentrations of arachidonic acid (2 mM).
Substance Class |
Chemical
Created
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admin
on
Edited
Fri Dec 15 15:42:21 UTC 2023
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Fri Dec 15 15:42:21 UTC 2023
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Record UNII |
6T9949G4LZ
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Record Status |
Validated (UNII)
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WHO-ATC |
B01AC10
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WHO-VATC |
QB01AC10
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NCI_THESAURUS |
C257
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DB12545
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m6271
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C83800
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100000088261
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36690-96-7
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6T9949G4LZ
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C020371
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DTXSID7057789
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INDOBUFEN
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107641
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CHEMBL1765292
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1439
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27518
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63610-08-2
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4398
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SUB08176MIG
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264-364-4
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Related Record | Type | Details | ||
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ENANTIOMER -> RACEMATE | |||
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SALT/SOLVATE -> PARENT |
Related Record | Type | Details | ||
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ACTIVE MOIETY |