Details
Stereochemistry | RACEMIC |
Molecular Formula | C18H16NO3.Na |
Molecular Weight | 317.3143 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[Na+].CCC(C([O-])=O)C1=CC=C(C=C1)N2CC3=CC=CC=C3C2=O
InChI
InChIKey=MEWDXXPKUBKKJO-UHFFFAOYSA-M
InChI=1S/C18H17NO3.Na/c1-2-15(18(21)22)12-7-9-14(10-8-12)19-11-13-5-3-4-6-16(13)17(19)20;/h3-10,15H,2,11H2,1H3,(H,21,22);/q;+1/p-1
Molecular Formula | Na |
Molecular Weight | 22.9898 |
Charge | 1 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | C18H16NO3 |
Molecular Weight | 294.3245 |
Charge | -1 |
Count |
|
Stereochemistry | RACEMIC |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Optical Activity | ( + / - ) |
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/1965501
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1965501
Indobufen inhibits platelet aggregation by reversibly inhibiting the platelet cyclooxygenase enzyme thereby suppressing thromboxane synthesis. Indobufen under brand name ibustrin is used in Italy for the following conditions: cerebrovascular insufficiency, atherosclerosis of peripheral and cerebral vessels, thrombophlebitis, deep vein thrombosis, and diabetes mellitus. In addition, this drug has been investigated in the phase II clinical trial for the prevention of thromboembolic events in patients with nonrheumatic atrial fibrillation. After oral administration, it is quickly and completely absorbed.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL2094253 Sources: https://www.ncbi.nlm.nih.gov/pubmed/1965501 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Preventing | Unknown Approved UseUnknown |
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Preventing | Ibustrin Approved UseUnknown |
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Preventing | Ibustrin Approved UseUnknown |
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Preventing | Ibustrin Approved UseUnknown |
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Palliative | Ibustrin Approved UseUnknown |
PubMed
Title | Date | PubMed |
---|---|---|
Indobufen: an updated review of its use in the management of atherothrombosis. | 2001 |
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Systematic review of long term anticoagulation or antiplatelet treatment in patients with non-rheumatic atrial fibrillation. | 2001 Feb 10 |
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Long term anticoagulation or antiplatelet treatment. Drug name was incorrect. | 2001 Jul 28 |
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Steady-state pharmacokinetics of indobufen enantiomers in patients with obliterative atherosclerosis. | 2001 Jun |
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[Thromboembolism in non-rheumatic atrial fibrillation]. | 2001 Sep |
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[Guidelines for antithrombotic therapy in atrial fibrillation: what the Italian Hemostasis and Thrombosis Society thinks]. | 2001 Sep |
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Protocol for Birmingham Atrial Fibrillation Treatment of the Aged study (BAFTA): a randomised controlled trial of warfarin versus aspirin for stroke prevention in the management of atrial fibrillation in an elderly primary care population [ISRCTN89345269]. | 2003 Aug 26 |
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Resolution of indobufen enantiomers by capillary zone electrophoresis. Pharmacokinetic studies of human serum. | 2004 Apr 2 |
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Endoscopic evaluation of the effects of indobufen and aspirin in healthy volunteers. | 2004 Mar-Apr |
Sample Use Guides
In Vivo Use Guide
Sources: https://clinicaltrials.gov/ct2/show/NCT00244426
indobufen capsules 100 and 200 mg
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3666587
At low concentrations (10 microM), indobufen completely inhibited secondary platelet aggregation, the release reaction and TxB2 production stimulated by ADP, epinephrine and low concentrations of platelet-activating factor (PAF acether). Higher concentrations of indobufen (100 microM) completely inhibited TxB2 production, platelet aggregation and ATP release induced by arachidonic acid (1 mM) or collagen (2 micrograms/ml). The inhibitory effect was partially overcome by higher concentrations of arachidonic acid (2 mM).
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 16:16:15 GMT 2023
by
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on
Fri Dec 15 16:16:15 GMT 2023
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Record UNII |
Y7A7KH8465
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Record Status |
Validated (UNII)
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Record Version |
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C257
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