KDM5-C49

CCN(CCN(C)C)C(=O)CNCC1=CC(=CC=N1)C(O)=O

InChIKey=RGGMVQDDHDCRDM-UHFFFAOYSA-N

InChI=1S/C15H24N4O3/c1-4-19(8-7-18(2)3)14(20)11-16-10-13-9-12(15(21)22)5-6-17-13/h5-6,9,16H,4,7-8,10-11H2,1-3H3,(H,21,22)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Targets

Primary Target	Pharmacology	Potency
Lysine-specific demethylase 5A 2 Target ID: CHEMBL2424504 Sources: https://www.ncbi.nlm.nih.gov/pubmed/27427228 \| https://www.ncbi.nlm.nih.gov/pubmed/27214403	Inhibitor 8297	40.0 nM [IC50]
Lysine-specific demethylase 5B 2 Target ID: Q9UGL1 Gene ID: 10765.0 Gene Symbol: KDM5B Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/27427228 \| https://www.ncbi.nlm.nih.gov/pubmed/27214403	Inhibitor 8297	160.0 nM [IC50]
Lysine-specific demethylase 5C 1 Target ID: CHEMBL2163176 Sources: https://www.ncbi.nlm.nih.gov/pubmed/27427228 \| https://www.ncbi.nlm.nih.gov/pubmed/27214403	Inhibitor 8297	100.0 nM [IC50]

Substance Class	Chemical Created by `admin` on `Sat Dec 16 12:37:08 GMT 2023` Edited by `admin` on `Sat Dec 16 12:37:08 GMT 2023`
Record UNII	6OQJ5L847C
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

KDM5-C49

Common Name

English

4-PYRIDINECARBOXYLIC ACID, 2-(((2-((2-(DIMETHYLAMINO)ETHYL)ETHYLAMINO)-2-OXOETHYL)AMINO)METHYL)-

Systematic Name

English

2-(((2-((2-(DIMETHYLAMINO)ETHYL)(ETHYL)AMINO)-2-OXOETHYL)AMINO)METHYL)ISONICOTINIC ACID

Systematic Name

English

Code System Code Type Description

PUBCHEM

86346639

Created by admin on Sat Dec 16 12:37:08 GMT 2023 , Edited by admin on Sat Dec 16 12:37:08 GMT 2023

PRIMARY

CAS

1596348-16-1

Created by admin on Sat Dec 16 12:37:08 GMT 2023 , Edited by admin on Sat Dec 16 12:37:08 GMT 2023

PRIMARY

FDA UNII

6OQJ5L847C

Created by admin on Sat Dec 16 12:37:08 GMT 2023 , Edited by admin on Sat Dec 16 12:37:08 GMT 2023

PRIMARY

Related Record Type Details

4288BE400F

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PRODRUG -> METABOLITE ACTIVE

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					6OQJ5L847C

KDM5-C49

ACTIVE MOIETY