ONTAMALIMAB

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Investigational

Approval Year

Substance Class	Protein Created by `admin` on `Mon Mar 31 22:27:56 GMT 2025` Edited by `admin` on `Mon Mar 31 22:27:56 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG2
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	6LGI7RV4PB
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

ONTAMALIMAB

Official Name

English

PF-00547659

Preferred Name

English

ontamalimab [INN]

Common Name

English

SHP647

Code

English

IMMUNOGLOBULIN G2, ANTI-(HUMAN MUCOSAL ADDRESSIN CELL ADHESION MOLECULE) (HUMAN MONOCLONAL SHP647 .GAMMA.2-CHAIN), DISULFIDE WITH HUMAN MONOCLONAL SHP647 .KAPPA.-CHAIN, DIMER

Common Name

English

FULLY HUMAN ANTI-HUMAN MADCAM IGG2.KAPPA. MONOCLONAL ANTIBODY

Common Name

English

SHP-647

Code

English

Ontamalimab [WHO-DD]

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

608117

Created by admin on Mon Mar 31 22:27:56 GMT 2025 , Edited by admin on Mon Mar 31 22:27:56 GMT 2025

FDA ORPHAN DRUG

608217

Created by admin on Mon Mar 31 22:27:56 GMT 2025 , Edited by admin on Mon Mar 31 22:27:56 GMT 2025

Code System Code Type Description

DRUG BANK

DB15298

Created by admin on Mon Mar 31 22:27:56 GMT 2025 , Edited by admin on Mon Mar 31 22:27:56 GMT 2025

PRIMARY

CAS

1822383-81-2

Created by admin on Mon Mar 31 22:27:56 GMT 2025 , Edited by admin on Mon Mar 31 22:27:56 GMT 2025

NO STRUCTURE GIVEN

INN

10903

Created by admin on Mon Mar 31 22:27:56 GMT 2025 , Edited by admin on Mon Mar 31 22:27:56 GMT 2025

PRIMARY

ChEMBL

CHEMBL2109511

Created by admin on Mon Mar 31 22:27:56 GMT 2025 , Edited by admin on Mon Mar 31 22:27:56 GMT 2025

PRIMARY

SMS_ID

100000178052

Created by admin on Mon Mar 31 22:27:56 GMT 2025 , Edited by admin on Mon Mar 31 22:27:56 GMT 2025

PRIMARY

NCI_THESAURUS

C166947

Created by admin on Mon Mar 31 22:27:56 GMT 2025 , Edited by admin on Mon Mar 31 22:27:56 GMT 2025

PRIMARY

CAS

2098790-40-8

Created by admin on Mon Mar 31 22:27:56 GMT 2025 , Edited by admin on Mon Mar 31 22:27:56 GMT 2025

PRIMARY

FDA UNII

6LGI7RV4PB

Created by admin on Mon Mar 31 22:27:56 GMT 2025 , Edited by admin on Mon Mar 31 22:27:56 GMT 2025

PRIMARY

From	To
2_264	2_324
1_264	1_324
1_22	1_96
1_138	3_219
1_151	1_207
1_226	2_226
1_227	2_227
1_230	2_230
1_233	2_233
1_370	1_428
2_22	2_96
2_138	4_219
2_151	2_207
2_370	2_428
3_23	3_93
3_139	3_199
4_23	4_93
4_139	4_199

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_300
N	2_300

Related Record Type Details


					S4D095HO80

MUCOSAL ADDRESSIN CELL ADHESION MOLECULE 1

TARGET -> INHIBITOR

Amount:

Related Record Type Details


					6LGI7RV4PB

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REPLACEMENT	[1_1] [2_1]		GLUTAMINE		PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(MASS SPECTROMETRY)	CHEMICAL
Molecular Formula	CHEMICAL